Found 4 hits for monomerid = 50381944 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Receptor-type tyrosine-protein kinase FLT3 [K633Q]
(Homo sapiens (Human)) | BDBM50381944
(CHEMBL2023801)Show SMILES CCc1n[nH]c(NC(=O)Cc2ncc(Oc3ccnc4cc(OC)c(OC)cc34)cc2OC)c1C Show InChI InChI=1S/C25H27N5O5/c1-6-17-14(2)25(30-29-17)28-24(31)12-19-21(32-3)9-15(13-27-19)35-20-7-8-26-18-11-23(34-5)22(33-4)10-16(18)20/h7-11,13H,6,12H2,1-5H3,(H2,28,29,30,31) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of Flt3 |
Bioorg Med Chem Lett 22: 3050-5 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.074
BindingDB Entry DOI: 10.7270/Q298881Z |
More data for this
Ligand-Target Pair | |
Macrophage colony-stimulating factor 1 receptor
(Homo sapiens (Human)) | BDBM50381944
(CHEMBL2023801)Show SMILES CCc1n[nH]c(NC(=O)Cc2ncc(Oc3ccnc4cc(OC)c(OC)cc34)cc2OC)c1C Show InChI InChI=1S/C25H27N5O5/c1-6-17-14(2)25(30-29-17)28-24(31)12-19-21(32-3)9-15(13-27-19)35-20-7-8-26-18-11-23(34-5)22(33-4)10-16(18)20/h7-11,13H,6,12H2,1-5H3,(H2,28,29,30,31) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 600 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of CSF-1R |
Bioorg Med Chem Lett 22: 3050-5 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.074
BindingDB Entry DOI: 10.7270/Q298881Z |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50381944
(CHEMBL2023801)Show SMILES CCc1n[nH]c(NC(=O)Cc2ncc(Oc3ccnc4cc(OC)c(OC)cc34)cc2OC)c1C Show InChI InChI=1S/C25H27N5O5/c1-6-17-14(2)25(30-29-17)28-24(31)12-19-21(32-3)9-15(13-27-19)35-20-7-8-26-18-11-23(34-5)22(33-4)10-16(18)20/h7-11,13H,6,12H2,1-5H3,(H2,28,29,30,31) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of PDGFRbeta |
Bioorg Med Chem Lett 22: 3050-5 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.074
BindingDB Entry DOI: 10.7270/Q298881Z |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50381944
(CHEMBL2023801)Show SMILES CCc1n[nH]c(NC(=O)Cc2ncc(Oc3ccnc4cc(OC)c(OC)cc34)cc2OC)c1C Show InChI InChI=1S/C25H27N5O5/c1-6-17-14(2)25(30-29-17)28-24(31)12-19-21(32-3)9-15(13-27-19)35-20-7-8-26-18-11-23(34-5)22(33-4)10-16(18)20/h7-11,13H,6,12H2,1-5H3,(H2,28,29,30,31) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >8.69E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of KDR |
Bioorg Med Chem Lett 22: 3050-5 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.074
BindingDB Entry DOI: 10.7270/Q298881Z |
More data for this
Ligand-Target Pair | |
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