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BDBM50383141 CHEMBL2031861

SMILES: C[C@@H]1CCCN1CCN1Cc2c(cccc2-c2ccc(cc2)C#N)C1=O

InChI Key: InChIKey=WMUZPZYJABHLGO-MRXNPFEDSA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50383141   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50383141
PNG
(CHEMBL2031861)
Show SMILES C[C@@H]1CCCN1CCN1Cc2c(cccc2-c2ccc(cc2)C#N)C1=O |r|
Show InChI InChI=1S/C22H23N3O/c1-16-4-3-11-24(16)12-13-25-15-21-19(5-2-6-20(21)22(25)26)18-9-7-17(14-23)8-10-18/h2,5-10,16H,3-4,11-13,15H2,1H3/t16-/m1/s1
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PC cid
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Article
PubMed
 23.8n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)-alpha-methylhistamine from human H3 receptor expressed in HEK293T cells after 120 mins by scintillation counting

J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair