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SMILES: COc1cc(Nc2ncc3CN(C)C(=O)N(c4cccc(NC(=O)C=C)c4)c3n2)ccc1N1CCN(C)CC1

InChI Key: InChIKey=NOVRNVMLNCWCAO-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50383284   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50383284
PNG
(CHEMBL2029429)
Show SMILES COc1cc(Nc2ncc3CN(C)C(=O)N(c4cccc(NC(=O)C=C)c4)c3n2)ccc1N1CCN(C)CC1
Show InChI InChI=1S/C28H32N8O3/c1-5-25(37)30-20-7-6-8-22(15-20)36-26-19(18-34(3)28(36)38)17-29-27(32-26)31-21-9-10-23(24(16-21)39-4)35-13-11-33(2)12-14-35/h5-10,15-17H,1,11-14,18H2,2-4H3,(H,30,37)(H,29,31,32)
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KEGG

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PC cid
PC sid
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Similars
Article
PubMed
n/an/a 0.410n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of EGFR after 1.5 hr by FRET assay

J Med Chem 55: 2711-23 (2012)


Article DOI: 10.1021/jm201591k
BindingDB Entry DOI: 10.7270/Q2K938JM
More data for this
Ligand-Target Pair