Found 5 hits for monomerid = 50384522 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
11-beta-hydroxysteroid dehydrogenase 1
(Mus musculus (mouse)) | BDBM50384522
(CHEMBL2036234)Show SMILES CC1CN(CC(=O)N[C@H]2C3CC4CC2C[C@](C4)(C3)C(N)=O)S(=O)(=O)N(C1)c1c(Cl)cc(Cl)cc1Cl |r,wU:8.7,wD:15.20,TLB:17:15:12:10.9.8,7:8:16.15.14:12,18:15:12:10.9.8,8:9:16:14.13.12,THB:17:9:16.15.14:12,8:13:16:10.17.9,(10.39,-6.25,;10.39,-7.79,;11.73,-8.57,;11.73,-10.12,;13.06,-10.89,;14.39,-10.13,;14.4,-8.59,;15.73,-10.9,;15.72,-12.44,;17.09,-13.12,;16.8,-14.53,;15.79,-15.51,;14.44,-14.87,;14.59,-13.45,;15.26,-14.93,;16.69,-15.6,;16.42,-17.14,;17.81,-14.58,;18.17,-16.01,;18.57,-17.5,;19.27,-14.93,;10.38,-10.88,;11.15,-12.22,;9.6,-12.21,;9.05,-10.12,;9.05,-8.57,;7.72,-10.89,;6.39,-10.12,;6.39,-8.58,;5.05,-10.9,;5.06,-12.44,;3.73,-13.22,;6.4,-13.2,;7.72,-12.43,;9.05,-13.2,)| Show InChI InChI=1S/C23H29Cl3N4O4S/c1-12-9-29(35(33,34)30(10-12)21-17(25)4-16(24)5-18(21)26)11-19(31)28-20-14-2-13-3-15(20)8-23(6-13,7-14)22(27)32/h4-5,12-15,20H,2-3,6-11H2,1H3,(H2,27,32)(H,28,31)/t12?,13?,14?,15?,20-,23- | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of mouse 11beta-HSD1 |
J Med Chem 57: 4466-86 (2014)
Article DOI: 10.1021/jm4014746 BindingDB Entry DOI: 10.7270/Q280546B |
More data for this Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50384522
(CHEMBL2036234)Show SMILES CC1CN(CC(=O)N[C@H]2C3CC4CC2C[C@](C4)(C3)C(N)=O)S(=O)(=O)N(C1)c1c(Cl)cc(Cl)cc1Cl |r,wU:8.7,wD:15.20,TLB:17:15:12:10.9.8,7:8:16.15.14:12,18:15:12:10.9.8,8:9:16:14.13.12,THB:17:9:16.15.14:12,8:13:16:10.17.9,(10.39,-6.25,;10.39,-7.79,;11.73,-8.57,;11.73,-10.12,;13.06,-10.89,;14.39,-10.13,;14.4,-8.59,;15.73,-10.9,;15.72,-12.44,;17.09,-13.12,;16.8,-14.53,;15.79,-15.51,;14.44,-14.87,;14.59,-13.45,;15.26,-14.93,;16.69,-15.6,;16.42,-17.14,;17.81,-14.58,;18.17,-16.01,;18.57,-17.5,;19.27,-14.93,;10.38,-10.88,;11.15,-12.22,;9.6,-12.21,;9.05,-10.12,;9.05,-8.57,;7.72,-10.89,;6.39,-10.12,;6.39,-8.58,;5.05,-10.9,;5.06,-12.44,;3.73,-13.22,;6.4,-13.2,;7.72,-12.43,;9.05,-13.2,)| Show InChI InChI=1S/C23H29Cl3N4O4S/c1-12-9-29(35(33,34)30(10-12)21-17(25)4-16(24)5-18(21)26)11-19(31)28-20-14-2-13-3-15(20)8-23(6-13,7-14)22(27)32/h4-5,12-15,20H,2-3,6-11H2,1H3,(H2,27,32)(H,28,31)/t12?,13?,14?,15?,20-,23- | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of human 11beta-HSD1 |
J Med Chem 57: 4466-86 (2014)
Article DOI: 10.1021/jm4014746 BindingDB Entry DOI: 10.7270/Q280546B |
More data for this Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Mus musculus (mouse)) | BDBM50384522
(CHEMBL2036234)Show SMILES CC1CN(CC(=O)N[C@H]2C3CC4CC2C[C@](C4)(C3)C(N)=O)S(=O)(=O)N(C1)c1c(Cl)cc(Cl)cc1Cl |r,wU:8.7,wD:15.20,TLB:17:15:12:10.9.8,7:8:16.15.14:12,18:15:12:10.9.8,8:9:16:14.13.12,THB:17:9:16.15.14:12,8:13:16:10.17.9,(10.39,-6.25,;10.39,-7.79,;11.73,-8.57,;11.73,-10.12,;13.06,-10.89,;14.39,-10.13,;14.4,-8.59,;15.73,-10.9,;15.72,-12.44,;17.09,-13.12,;16.8,-14.53,;15.79,-15.51,;14.44,-14.87,;14.59,-13.45,;15.26,-14.93,;16.69,-15.6,;16.42,-17.14,;17.81,-14.58,;18.17,-16.01,;18.57,-17.5,;19.27,-14.93,;10.38,-10.88,;11.15,-12.22,;9.6,-12.21,;9.05,-10.12,;9.05,-8.57,;7.72,-10.89,;6.39,-10.12,;6.39,-8.58,;5.05,-10.9,;5.06,-12.44,;3.73,-13.22,;6.4,-13.2,;7.72,-12.43,;9.05,-13.2,)| Show InChI InChI=1S/C23H29Cl3N4O4S/c1-12-9-29(35(33,34)30(10-12)21-17(25)4-16(24)5-18(21)26)11-19(31)28-20-14-2-13-3-15(20)8-23(6-13,7-14)22(27)32/h4-5,12-15,20H,2-3,6-11H2,1H3,(H2,27,32)(H,28,31)/t12?,13?,14?,15?,20-,23- | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of mouse 11beta-HSD1 expressed in CHO-K1 cells using cortisone as substrate after 3 hrs by HTRF assay |
ACS Med Chem Lett 3: 88-93 (2012)
Article DOI: 10.1021/ml200226x BindingDB Entry DOI: 10.7270/Q2TH8NR0 |
More data for this Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50384522
(CHEMBL2036234)Show SMILES CC1CN(CC(=O)N[C@H]2C3CC4CC2C[C@](C4)(C3)C(N)=O)S(=O)(=O)N(C1)c1c(Cl)cc(Cl)cc1Cl |r,wU:8.7,wD:15.20,TLB:17:15:12:10.9.8,7:8:16.15.14:12,18:15:12:10.9.8,8:9:16:14.13.12,THB:17:9:16.15.14:12,8:13:16:10.17.9,(10.39,-6.25,;10.39,-7.79,;11.73,-8.57,;11.73,-10.12,;13.06,-10.89,;14.39,-10.13,;14.4,-8.59,;15.73,-10.9,;15.72,-12.44,;17.09,-13.12,;16.8,-14.53,;15.79,-15.51,;14.44,-14.87,;14.59,-13.45,;15.26,-14.93,;16.69,-15.6,;16.42,-17.14,;17.81,-14.58,;18.17,-16.01,;18.57,-17.5,;19.27,-14.93,;10.38,-10.88,;11.15,-12.22,;9.6,-12.21,;9.05,-10.12,;9.05,-8.57,;7.72,-10.89,;6.39,-10.12,;6.39,-8.58,;5.05,-10.9,;5.06,-12.44,;3.73,-13.22,;6.4,-13.2,;7.72,-12.43,;9.05,-13.2,)| Show InChI InChI=1S/C23H29Cl3N4O4S/c1-12-9-29(35(33,34)30(10-12)21-17(25)4-16(24)5-18(21)26)11-19(31)28-20-14-2-13-3-15(20)8-23(6-13,7-14)22(27)32/h4-5,12-15,20H,2-3,6-11H2,1H3,(H2,27,32)(H,28,31)/t12?,13?,14?,15?,20-,23- | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of human 11beta-HSD1 expressed in CHO-K1 cells using cortisone as substrate after 3 hrs by HTRF assay |
ACS Med Chem Lett 3: 88-93 (2012)
Article DOI: 10.1021/ml200226x BindingDB Entry DOI: 10.7270/Q2TH8NR0 |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50384522
(CHEMBL2036234)Show SMILES CC1CN(CC(=O)N[C@H]2C3CC4CC2C[C@](C4)(C3)C(N)=O)S(=O)(=O)N(C1)c1c(Cl)cc(Cl)cc1Cl |r,wU:8.7,wD:15.20,TLB:17:15:12:10.9.8,7:8:16.15.14:12,18:15:12:10.9.8,8:9:16:14.13.12,THB:17:9:16.15.14:12,8:13:16:10.17.9,(10.39,-6.25,;10.39,-7.79,;11.73,-8.57,;11.73,-10.12,;13.06,-10.89,;14.39,-10.13,;14.4,-8.59,;15.73,-10.9,;15.72,-12.44,;17.09,-13.12,;16.8,-14.53,;15.79,-15.51,;14.44,-14.87,;14.59,-13.45,;15.26,-14.93,;16.69,-15.6,;16.42,-17.14,;17.81,-14.58,;18.17,-16.01,;18.57,-17.5,;19.27,-14.93,;10.38,-10.88,;11.15,-12.22,;9.6,-12.21,;9.05,-10.12,;9.05,-8.57,;7.72,-10.89,;6.39,-10.12,;6.39,-8.58,;5.05,-10.9,;5.06,-12.44,;3.73,-13.22,;6.4,-13.2,;7.72,-12.43,;9.05,-13.2,)| Show InChI InChI=1S/C23H29Cl3N4O4S/c1-12-9-29(35(33,34)30(10-12)21-17(25)4-16(24)5-18(21)26)11-19(31)28-20-14-2-13-3-15(20)8-23(6-13,7-14)22(27)32/h4-5,12-15,20H,2-3,6-11H2,1H3,(H2,27,32)(H,28,31)/t12?,13?,14?,15?,20-,23- | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of human ERG |
J Med Chem 57: 4466-86 (2014)
Article DOI: 10.1021/jm4014746 BindingDB Entry DOI: 10.7270/Q280546B |
More data for this Ligand-Target Pair | |