BDBM50384577 CHEMBL2036791::US9744172, Compound UNC00000489A

SMILES: CNc1ncc2c(nn(CC3CCC(N)CC3)c2n1)-c1ccc(nc1)N1CCNCC1

InChI Key: InChIKey=ISZNFBSZRWOLFS-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50384577   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM50384577 (CHEMBL2036791 | US9744172, Compound UNC00000489A) Show SMILES CNc1ncc2c(nn(CC3CCC(N)CC3)c2n1)-c1ccc(nc1)N1CCNCC1 |(38.98,-28.18,;40.32,-28.95,;41.65,-28.18,;41.65,-26.64,;42.98,-25.87,;44.32,-26.63,;45.79,-26.15,;46.7,-27.41,;45.79,-28.66,;46.27,-30.13,;45.24,-31.27,;43.73,-30.94,;42.7,-32.08,;43.17,-33.54,;42.14,-34.69,;44.68,-33.87,;45.72,-32.73,;44.32,-28.18,;42.98,-28.95,;46.27,-24.69,;45.24,-23.55,;45.71,-22.09,;47.22,-21.76,;48.25,-22.91,;47.77,-24.37,;47.69,-20.3,;49.2,-19.98,;49.67,-18.53,;48.64,-17.38,;47.14,-17.7,;46.65,-19.17,)| Show InChI InChI=1S/C22H31N9/c1-24-22-27-13-18-20(16-4-7-19(26-12-16)30-10-8-25-9-11-30)29-31(21(18)28-22)14-15-2-5-17(23)6-3-15/h4,7,12-13,15,17,25H,2-3,5-6,8-11,14,23H2,1H3,(H,24,27,28)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	57	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of Axl using KKKKEEIYFFF-CONH2 as substrate after 180 mins by microfluid capillary electrophoresis assay				ACS Med Chem Lett 3: 129-134 (2012) Article DOI: 10.1021/ml200239k BindingDB Entry DOI: 10.7270/Q2F76DMC
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM50384577 (CHEMBL2036791 | US9744172, Compound UNC00000489A) Show SMILES CNc1ncc2c(nn(CC3CCC(N)CC3)c2n1)-c1ccc(nc1)N1CCNCC1 |(38.98,-28.18,;40.32,-28.95,;41.65,-28.18,;41.65,-26.64,;42.98,-25.87,;44.32,-26.63,;45.79,-26.15,;46.7,-27.41,;45.79,-28.66,;46.27,-30.13,;45.24,-31.27,;43.73,-30.94,;42.7,-32.08,;43.17,-33.54,;42.14,-34.69,;44.68,-33.87,;45.72,-32.73,;44.32,-28.18,;42.98,-28.95,;46.27,-24.69,;45.24,-23.55,;45.71,-22.09,;47.22,-21.76,;48.25,-22.91,;47.77,-24.37,;47.69,-20.3,;49.2,-19.98,;49.67,-18.53,;48.64,-17.38,;47.14,-17.7,;46.65,-19.17,)| Show InChI InChI=1S/C22H31N9/c1-24-22-27-13-18-20(16-4-7-19(26-12-16)30-10-8-25-9-11-30)29-31(21(18)28-22)14-15-2-5-17(23)6-3-15/h4,7,12-13,15,17,25H,2-3,5-6,8-11,14,23H2,1H3,(H,24,27,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
The University of North Carolina at Chapel Hill US Patent					Assay Description The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...				US Patent US9744172 (2017) BindingDB Entry DOI: 10.7270/Q2PR7Z30
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM50384577 (CHEMBL2036791 | US9744172, Compound UNC00000489A) Show SMILES CNc1ncc2c(nn(CC3CCC(N)CC3)c2n1)-c1ccc(nc1)N1CCNCC1 |(38.98,-28.18,;40.32,-28.95,;41.65,-28.18,;41.65,-26.64,;42.98,-25.87,;44.32,-26.63,;45.79,-26.15,;46.7,-27.41,;45.79,-28.66,;46.27,-30.13,;45.24,-31.27,;43.73,-30.94,;42.7,-32.08,;43.17,-33.54,;42.14,-34.69,;44.68,-33.87,;45.72,-32.73,;44.32,-28.18,;42.98,-28.95,;46.27,-24.69,;45.24,-23.55,;45.71,-22.09,;47.22,-21.76,;48.25,-22.91,;47.77,-24.37,;47.69,-20.3,;49.2,-19.98,;49.67,-18.53,;48.64,-17.38,;47.14,-17.7,;46.65,-19.17,)| Show InChI InChI=1S/C22H31N9/c1-24-22-27-13-18-20(16-4-7-19(26-12-16)30-10-8-25-9-11-30)29-31(21(18)28-22)14-15-2-5-17(23)6-3-15/h4,7,12-13,15,17,25H,2-3,5-6,8-11,14,23H2,1H3,(H,24,27,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	64	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of Mer expressed in Escherichia coli BL21 (DE3) cells using EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluid capillary electr...				ACS Med Chem Lett 3: 129-134 (2012) Article DOI: 10.1021/ml200239k BindingDB Entry DOI: 10.7270/Q2F76DMC
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM50384577 (CHEMBL2036791 | US9744172, Compound UNC00000489A) Show SMILES CNc1ncc2c(nn(CC3CCC(N)CC3)c2n1)-c1ccc(nc1)N1CCNCC1 |(38.98,-28.18,;40.32,-28.95,;41.65,-28.18,;41.65,-26.64,;42.98,-25.87,;44.32,-26.63,;45.79,-26.15,;46.7,-27.41,;45.79,-28.66,;46.27,-30.13,;45.24,-31.27,;43.73,-30.94,;42.7,-32.08,;43.17,-33.54,;42.14,-34.69,;44.68,-33.87,;45.72,-32.73,;44.32,-28.18,;42.98,-28.95,;46.27,-24.69,;45.24,-23.55,;45.71,-22.09,;47.22,-21.76,;48.25,-22.91,;47.77,-24.37,;47.69,-20.3,;49.2,-19.98,;49.67,-18.53,;48.64,-17.38,;47.14,-17.7,;46.65,-19.17,)| Show InChI InChI=1S/C22H31N9/c1-24-22-27-13-18-20(16-4-7-19(26-12-16)30-10-8-25-9-11-30)29-31(21(18)28-22)14-15-2-5-17(23)6-3-15/h4,7,12-13,15,17,25H,2-3,5-6,8-11,14,23H2,1H3,(H,24,27,28)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	640	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of Tyro3 using EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluid capillary electrophoresis assay				ACS Med Chem Lett 3: 129-134 (2012) Article DOI: 10.1021/ml200239k BindingDB Entry DOI: 10.7270/Q2F76DMC
					More data for this Ligand-Target Pair