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BDBM50384774 CHEMBL1917204

SMILES: Cc1ccc(cc1)-n1sc(=O)n(Cc2ccc(F)cc2)c1=O

InChI Key: InChIKey=QUIIIYITNGOFEI-UHFFFAOYSA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50384774   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Regulator of G-protein signaling 4 (RGS4)


(Homo sapiens (Human))
BDBM50384774
PNG
(CHEMBL1917204)
Show SMILES Cc1ccc(cc1)-n1sc(=O)n(Cc2ccc(F)cc2)c1=O
Show InChI InChI=1S/C16H13FN2O2S/c1-11-2-8-14(9-3-11)19-15(20)18(16(21)22-19)10-12-4-6-13(17)7-5-12/h2-9H,10H2,1H3
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PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 30n/an/an/an/an/an/a



The Regents of The University of Michigan; The University of Bath

US Patent


Assay Description
FCPIA Characterization of RGS Inhibitory Activity: CCG-50014 (FIG. 1) was originally identified as a potential inhibitor of RGS8 and RGS16 in a polyp...


Citation and Details
More data for this
Ligand-Target Pair
Regulator of G-protein signaling 8


(Homo sapiens)
BDBM50384774
PNG
(CHEMBL1917204)
Show SMILES Cc1ccc(cc1)-n1sc(=O)n(Cc2ccc(F)cc2)c1=O
Show InChI InChI=1S/C16H13FN2O2S/c1-11-2-8-14(9-3-11)19-15(20)18(16(21)22-19)10-12-4-6-13(17)7-5-12/h2-9H,10H2,1H3
PDB
MMDB

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CHEMBL
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.10E+4n/an/an/an/an/an/a



The Regents of The University of Michigan; The University of Bath

US Patent


Assay Description
FCPIA Characterization of RGS Inhibitory Activity: CCG-50014 (FIG. 1) was originally identified as a potential inhibitor of RGS8 and RGS16 in a polyp...


Citation and Details
More data for this
Ligand-Target Pair
Regulator of G-protein signaling 4 (RGS4)


(Homo sapiens (Human))
BDBM50384774
PNG
(CHEMBL1917204)
Show SMILES Cc1ccc(cc1)-n1sc(=O)n(Cc2ccc(F)cc2)c1=O
Show InChI InChI=1S/C16H13FN2O2S/c1-11-2-8-14(9-3-11)19-15(20)18(16(21)22-19)10-12-4-6-13(17)7-5-12/h2-9H,10H2,1H3
PDB

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UniProtKB/SwissProt

B.MOAD
antibodypedia
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CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 30n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of RGS4 interaction with Galpha0 protein by flow cytometry protein interaction assay


Citation and Details
More data for this
Ligand-Target Pair
G protein signalling regulator 19


(Homo sapiens)
BDBM50384774
PNG
(CHEMBL1917204)
Show SMILES Cc1ccc(cc1)-n1sc(=O)n(Cc2ccc(F)cc2)c1=O
Show InChI InChI=1S/C16H13FN2O2S/c1-11-2-8-14(9-3-11)19-15(20)18(16(21)22-19)10-12-4-6-13(17)7-5-12/h2-9H,10H2,1H3
PDB
MMDB

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UniProtKB/SwissProt

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antibodypedia
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CHEMBL
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 120n/an/an/an/an/an/a



The Regents of The University of Michigan; The University of Bath

US Patent


Assay Description
FCPIA Characterization of RGS Inhibitory Activity: CCG-50014 (FIG. 1) was originally identified as a potential inhibitor of RGS8 and RGS16 in a polyp...


Citation and Details
More data for this
Ligand-Target Pair
Regulator of G-protein signaling 8


(Homo sapiens)
BDBM50384774
PNG
(CHEMBL1917204)
Show SMILES Cc1ccc(cc1)-n1sc(=O)n(Cc2ccc(F)cc2)c1=O
Show InChI InChI=1S/C16H13FN2O2S/c1-11-2-8-14(9-3-11)19-15(20)18(16(21)22-19)10-12-4-6-13(17)7-5-12/h2-9H,10H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
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CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 1.10E+4n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of RGS8 interaction with Galpha0 protein by flow cytometry protein interaction assay


Citation and Details
More data for this
Ligand-Target Pair
regulator of G-protein signalling 16


(Homo sapiens)
BDBM50384774
PNG
(CHEMBL1917204)
Show SMILES Cc1ccc(cc1)-n1sc(=O)n(Cc2ccc(F)cc2)c1=O
Show InChI InChI=1S/C16H13FN2O2S/c1-11-2-8-14(9-3-11)19-15(20)18(16(21)22-19)10-12-4-6-13(17)7-5-12/h2-9H,10H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 3.50E+3n/an/an/an/an/an/a



The Regents of The University of Michigan; The University of Bath

US Patent


Assay Description
FCPIA Characterization of RGS Inhibitory Activity: CCG-50014 (FIG. 1) was originally identified as a potential inhibitor of RGS8 and RGS16 in a polyp...


Citation and Details
More data for this
Ligand-Target Pair