BindingDB PrimarySearch

BDBM50385309 CHEMBL2035983

SMILES: C[C@]1(CNC2(CCCC2)C(=O)N1CC(=O)Nc1cnc2C[C@]3(Cc2c1)C(=O)Nc1ncccc31)c1cc(F)cc(F)c1

InChI Key: InChIKey=IDKKNSOZWQOAAS-KYJUHHDHSA-N

Data: 9 KI 5 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50385309
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Calcitonin gene-related peptide type 1 receptor (Homo sapiens (Human))	BDBM50385309 (CHEMBL2035983) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.0520	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Displacement of [125I]CGRP from CGRP receptor in human SK-N-MC cells after 3 hrs				Bioorg Med Chem Lett 22: 3941-5 (2012) Article DOI: 10.1016/j.bmcl.2012.04.105 BindingDB Entry DOI: 10.7270/Q2FX7BG1
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Amylin receptor AMY1, CALCR/RAMP1 (Homo sapiens (Human))	BDBM50385309 (CHEMBL2035983) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.640	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Displacement of [125I]amylin from human AMY1 receptor expressed in COS7 cells after 3 hrs				Bioorg Med Chem Lett 22: 3941-5 (2012) Article DOI: 10.1016/j.bmcl.2012.04.105 BindingDB Entry DOI: 10.7270/Q2FX7BG1
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Calcitonin gene-related peptide type 1 receptor (Rattus norvegicus)	BDBM50385309 (CHEMBL2035983) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	17	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Displacement of [125I]CGRP from CGRP receptor in rat brain membrane after 3 hrs				Bioorg Med Chem Lett 22: 3941-5 (2012) Article DOI: 10.1016/j.bmcl.2012.04.105 BindingDB Entry DOI: 10.7270/Q2FX7BG1
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Calcitonin gene-related peptide type 1 receptor (Mus musculus)	BDBM50385309 (CHEMBL2035983) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	19	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Displacement of [125I]CGRP from mouse CGRP receptor				Bioorg Med Chem Lett 22: 3941-5 (2012) Article DOI: 10.1016/j.bmcl.2012.04.105 BindingDB Entry DOI: 10.7270/Q2FX7BG1
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Calcitonin gene-related peptide type 1 receptor/Receptor activity-modifying protein 1 (Homo sapiens (Human))	BDBM50385309 (CHEMBL2035983) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	47	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Displacement of [125I]CGRP from human recombinant CALCRL/RAMP1 receptor expressed in HEK293 cells after 3 hrs				Bioorg Med Chem Lett 22: 3941-5 (2012) Article DOI: 10.1016/j.bmcl.2012.04.105 BindingDB Entry DOI: 10.7270/Q2FX7BG1
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Adrenomedullin receptor, AM2; CALCRL/RAMP3 (Homo sapiens (Human))	BDBM50385309 (CHEMBL2035983) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	590	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Displacement of [125I]adrenomedullin from human AM2 receptor expressed in HEK293 cells				Bioorg Med Chem Lett 22: 3941-5 (2012) Article DOI: 10.1016/j.bmcl.2012.04.105 BindingDB Entry DOI: 10.7270/Q2FX7BG1
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Amylin receptor AMY3; CALCR/RAMP3 (Homo sapiens (Human))	BDBM50385309 (CHEMBL2035983) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Displacement of [125I]amylin from human AMY3 receptor expressed in COS7 cells after 3 hrs				Bioorg Med Chem Lett 22: 3941-5 (2012) Article DOI: 10.1016/j.bmcl.2012.04.105 BindingDB Entry DOI: 10.7270/Q2FX7BG1
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Calcitonin receptor (Homo sapiens (Human))	BDBM50385309 (CHEMBL2035983) Show SMILES Show InChI	PDB Reactome pathway KEGG DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3.20E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Displacement of [125I]calcitonin from human CT receptor expressed in HEK293 cells				Bioorg Med Chem Lett 22: 3941-5 (2012) Article DOI: 10.1016/j.bmcl.2012.04.105 BindingDB Entry DOI: 10.7270/Q2FX7BG1
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Adrenomedullin receptor AM1, CALCRL/RAMP2 (Homo sapiens (Human))	BDBM50385309 (CHEMBL2035983) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Displacement of [125I]adrenomedullin from human AM1 receptor expressed in HEK293 cells				Bioorg Med Chem Lett 22: 3941-5 (2012) Article DOI: 10.1016/j.bmcl.2012.04.105 BindingDB Entry DOI: 10.7270/Q2FX7BG1
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Voltage-gated potassium channel beta subunit Mink (Homo sapiens (Human))	BDBM50385309 (CHEMBL2035983) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of Iks ion channel by voltage clamp assay				Bioorg Med Chem Lett 22: 3941-5 (2012) Article DOI: 10.1016/j.bmcl.2012.04.105 BindingDB Entry DOI: 10.7270/Q2FX7BG1
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human))	BDBM50385309 (CHEMBL2035983) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of NaV1.5 ion channel by voltage clamp assay				Bioorg Med Chem Lett 22: 3941-5 (2012) Article DOI: 10.1016/j.bmcl.2012.04.105 BindingDB Entry DOI: 10.7270/Q2FX7BG1
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Calcium channel (Type L) (Homo sapiens (Human))	BDBM50385309 (CHEMBL2035983) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of CaV1.2 ion channel by voltage clamp assay				Bioorg Med Chem Lett 22: 3941-5 (2012) Article DOI: 10.1016/j.bmcl.2012.04.105 BindingDB Entry DOI: 10.7270/Q2FX7BG1
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Calcitonin gene-related peptide type 1 receptor (Homo sapiens (Human))	BDBM50385309 (CHEMBL2035983) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.340	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Antagonist activity at human CGRP receptor expressed in HEK293 cells assessed as inhibition of CGRP-induced cAMP response after 5 mins in the presenc...				Bioorg Med Chem Lett 22: 3941-5 (2012) Article DOI: 10.1016/j.bmcl.2012.04.105 BindingDB Entry DOI: 10.7270/Q2FX7BG1
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Calcitonin gene-related peptide type 1 receptor (Homo sapiens (Human))	BDBM50385309 (CHEMBL2035983) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.230	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Antagonist activity at human CGRP receptor expressed in HEK293 cells assessed as inhibition of CGRP-induced cAMP response after 5 mins in the absence...				Bioorg Med Chem Lett 22: 3941-5 (2012) Article DOI: 10.1016/j.bmcl.2012.04.105 BindingDB Entry DOI: 10.7270/Q2FX7BG1
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair