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BDBM50385850 CHEMBL2042853

SMILES: Cc1cccnc1CN1CCC2(CC1)C(=O)N(c1ccccc21)c1ccc(cc1)-c1ccccc1

InChI Key: InChIKey=OENWMSHFDNZIBX-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50385850   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Egl nine homolog 1


(Homo sapiens (Human))
BDBM50385850
PNG
(CHEMBL2042853)
Show SMILES Cc1cccnc1CN1CCC2(CC1)C(=O)N(c1ccccc21)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C31H29N3O/c1-23-8-7-19-32-28(23)22-33-20-17-31(18-21-33)27-11-5-6-12-29(27)34(30(31)35)26-15-13-25(14-16-26)24-9-3-2-4-10-24/h2-16,19H,17-18,20-22H2,1H3
PDB
MMDB

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UniProtKB/SwissProt

B.MOAD
DrugBank
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AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FLAG-tagged PHD2 expressed in baculovirus infected insect sf9 cells using biotinyl-DLDLEMLAPYIPMDDDFQL as substrate preincubated with c...


J Med Chem 55: 2945-59 (2012)


Article DOI: 10.1021/jm201542d
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM50385850
PNG
(CHEMBL2042853)
Show SMILES Cc1cccnc1CN1CCC2(CC1)C(=O)N(c1ccccc21)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C31H29N3O/c1-23-8-7-19-32-28(23)22-33-20-17-31(18-21-33)27-11-5-6-12-29(27)34(30(31)35)26-15-13-25(14-16-26)24-9-3-2-4-10-24/h2-16,19H,17-18,20-22H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 0.501n/an/an/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of PHD2 (unknown origin) by HTRF assay


Bioorg Med Chem 21: 6349-58 (2013)


Article DOI: 10.1016/j.bmc.2013.08.046
More data for this
Ligand-Target Pair