Found 4 hits for monomerid = 50387541 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM50387541
(CHEMBL2057368)Show SMILES CC(C)(C)NS(=O)(=O)c1cncc(c1)-c1ccc2nc(NC(=O)NCCn3nnc(n3)C3CC3)nn2c1 Show InChI InChI=1S/C22H27N11O3S/c1-22(2,3)30-37(35,36)17-10-16(11-23-12-17)15-6-7-18-25-20(29-32(18)13-15)26-21(34)24-8-9-33-28-19(27-31-33)14-4-5-14/h6-7,10-14,30H,4-5,8-9H2,1-3H3,(H2,24,26,29,34) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.51 | n/a | n/a | n/a | n/a | n/a | n/a |
Cellzome Ltd
Curated by ChEMBL
| Assay Description
Inhibition of PI3Kgamma in human HL60 cell lysate by kinobead assay |
Bioorg Med Chem Lett 22: 4546-9 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.121
BindingDB Entry DOI: 10.7270/Q2J38TMN |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50387541
(CHEMBL2057368)Show SMILES CC(C)(C)NS(=O)(=O)c1cncc(c1)-c1ccc2nc(NC(=O)NCCn3nnc(n3)C3CC3)nn2c1 Show InChI InChI=1S/C22H27N11O3S/c1-22(2,3)30-37(35,36)17-10-16(11-23-12-17)15-6-7-18-25-20(29-32(18)13-15)26-21(34)24-8-9-33-28-19(27-31-33)14-4-5-14/h6-7,10-14,30H,4-5,8-9H2,1-3H3,(H2,24,26,29,34) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 63.1 | n/a | n/a | n/a | n/a | n/a | n/a |
Cellzome Ltd
Curated by ChEMBL
| Assay Description
Inhibition of PI3Kbeta in human HL60 cell lysate by kinobead assay |
Bioorg Med Chem Lett 22: 4546-9 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.121
BindingDB Entry DOI: 10.7270/Q2J38TMN |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50387541
(CHEMBL2057368)Show SMILES CC(C)(C)NS(=O)(=O)c1cncc(c1)-c1ccc2nc(NC(=O)NCCn3nnc(n3)C3CC3)nn2c1 Show InChI InChI=1S/C22H27N11O3S/c1-22(2,3)30-37(35,36)17-10-16(11-23-12-17)15-6-7-18-25-20(29-32(18)13-15)26-21(34)24-8-9-33-28-19(27-31-33)14-4-5-14/h6-7,10-14,30H,4-5,8-9H2,1-3H3,(H2,24,26,29,34) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 794 | n/a | n/a | n/a | n/a | n/a | n/a |
Cellzome Ltd
Curated by ChEMBL
| Assay Description
Inhibition of PI3Kalpha in human HL60 cell lysate by kinobead assay |
Bioorg Med Chem Lett 22: 4546-9 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.121
BindingDB Entry DOI: 10.7270/Q2J38TMN |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50387541
(CHEMBL2057368)Show SMILES CC(C)(C)NS(=O)(=O)c1cncc(c1)-c1ccc2nc(NC(=O)NCCn3nnc(n3)C3CC3)nn2c1 Show InChI InChI=1S/C22H27N11O3S/c1-22(2,3)30-37(35,36)17-10-16(11-23-12-17)15-6-7-18-25-20(29-32(18)13-15)26-21(34)24-8-9-33-28-19(27-31-33)14-4-5-14/h6-7,10-14,30H,4-5,8-9H2,1-3H3,(H2,24,26,29,34) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.31 | n/a | n/a | n/a | n/a | n/a | n/a |
Cellzome Ltd
Curated by ChEMBL
| Assay Description
Inhibition of PI3Kdelta in human HL60 cell lysate by kinobead assay |
Bioorg Med Chem Lett 22: 4546-9 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.121
BindingDB Entry DOI: 10.7270/Q2J38TMN |
More data for this
Ligand-Target Pair | |
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