BindingDB PrimarySearch

BDBM50387877 CHEMBL2057795

SMILES: CCN1CCN(CC1)c1nc(C)nc2sc(cc12)-c1ccccc1

InChI Key: InChIKey=CWQYMWNABHHDQG-UHFFFAOYSA-N

Data: 2 KI 3 IC50 3 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50387877
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Cannabinoid receptor 2 (Rattus norvegicus (Rat))	BDBM50387877 (CHEMBL2057795) Show SMILES CCN1CCN(CC1)c1nc(C)nc2sc(cc12)-c1ccccc1 Show InChI	KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	16	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Displacement of [3H]-CP-55,940 from rat CB2 receptor expressed in CHO cells				Bioorg Med Chem Lett 22: 4962-6 (2012) Article DOI: 10.1016/j.bmcl.2012.06.035 BindingDB Entry DOI: 10.7270/Q2Z60Q3D
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Cannabinoid receptor 2 (Homo sapiens (Human))	BDBM50387877 (CHEMBL2057795) Show SMILES CCN1CCN(CC1)c1nc(C)nc2sc(cc12)-c1ccccc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	82	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Displacement of [3H]-CP-55,940 from human CB2 receptor expressed in CHO cells				Bioorg Med Chem Lett 22: 4962-6 (2012) Article DOI: 10.1016/j.bmcl.2012.06.035 BindingDB Entry DOI: 10.7270/Q2Z60Q3D
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Cannabinoid receptor 1 (Homo sapiens (Human))	BDBM50387877 (CHEMBL2057795) Show SMILES CCN1CCN(CC1)c1nc(C)nc2sc(cc12)-c1ccccc1 Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.60E+3	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Agonist activity at human CB1 receptor expressed in CHO cells assessed as [35S]-GTPgammaS binding preincubated for 25 mins measured after 30 mins by ...				Bioorg Med Chem Lett 22: 4962-6 (2012) Article DOI: 10.1016/j.bmcl.2012.06.035 BindingDB Entry DOI: 10.7270/Q2Z60Q3D
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Cannabinoid receptor (Rattus norvegicus (rat))	BDBM50387877 (CHEMBL2057795) Show SMILES CCN1CCN(CC1)c1nc(C)nc2sc(cc12)-c1ccccc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Agonist activity at CB1 receptor in rat cerebellar homogenates assessed as stimulation of [35S]GTPgamma binding				J Med Chem 56: 5722-33 (2013) Article DOI: 10.1021/jm400305d BindingDB Entry DOI: 10.7270/Q2BR8W4W
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50387877 (CHEMBL2057795) Show SMILES CCN1CCN(CC1)c1nc(C)nc2sc(cc12)-c1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Displacement of [3H]dofetilide from human Erg expressed in human HEK293 cells				Bioorg Med Chem Lett 22: 4962-6 (2012) Article DOI: 10.1016/j.bmcl.2012.06.035 BindingDB Entry DOI: 10.7270/Q2Z60Q3D
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 2D6 (Homo sapiens (Human))	BDBM50387877 (CHEMBL2057795) Show SMILES CCN1CCN(CC1)c1nc(C)nc2sc(cc12)-c1ccccc1 Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibition of CYP2D6				Bioorg Med Chem Lett 22: 4962-6 (2012) Article DOI: 10.1016/j.bmcl.2012.06.035 BindingDB Entry DOI: 10.7270/Q2Z60Q3D
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Cannabinoid receptor (Rattus norvegicus (rat))	BDBM50387877 (CHEMBL2057795) Show SMILES CCN1CCN(CC1)c1nc(C)nc2sc(cc12)-c1ccccc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Antagonist activity at CB1 receptor in rat cerebellar homogenates assessed as inhibition of CP-55,940-stimulated [35S]GTPgamma binding				J Med Chem 56: 5722-33 (2013) Article DOI: 10.1021/jm400305d BindingDB Entry DOI: 10.7270/Q2BR8W4W
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Cannabinoid receptor 2 (Homo sapiens (Human))	BDBM50387877 (CHEMBL2057795) Show SMILES CCN1CCN(CC1)c1nc(C)nc2sc(cc12)-c1ccccc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	24.8	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Agonist activity at human CB2 receptor expressed in CHO cells assessed as [35S]-GTPgammaS binding preincubated for 25 mins measured after 30 mins by ...				Bioorg Med Chem Lett 22: 4962-6 (2012) Article DOI: 10.1016/j.bmcl.2012.06.035 BindingDB Entry DOI: 10.7270/Q2Z60Q3D
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair