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SMILES: CN(C)C[C@@H](OC(=O)N1Cc2c(NC(=O)C3CCCO3)[nH]nc2C1(C)C)c1ccccc1

InChI Key: InChIKey=FDPSERWZLVMCNT-QRWMCTBCSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50389122   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine/threonine-protein kinase PAK 4


(Homo sapiens (Human))		BDBM50389122
PNG
(CHEMBL2064629)
Show SMILES CN(C)C[C@@H](OC(=O)N1Cc2c(NC(=O)C3CCCO3)[nH]nc2C1(C)C)c1ccccc1 |r|
Show InChI InChI=1S/C23H31N5O4/c1-23(2)19-16(20(26-25-19)24-21(29)17-11-8-12-31-17)13-28(23)22(30)32-18(14-27(3)4)15-9-6-5-7-10-15/h5-7,9-10,17-18H,8,11-14H2,1-4H3,(H2,24,25,26,29)/t17?,18-/m1/s1
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Article
PubMed
n/an/an/an/a 16n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PAK4-mediated GEF-H1 phosphorylation at Ser810 by cell based assay

J Med Chem 55: 4728-39 (2012)


Article DOI: 10.1021/jm300204j
BindingDB Entry DOI: 10.7270/Q2BZ673W
More data for this
Ligand-Target Pair