Found 4 hits for monomerid = 50389232 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Aurora kinase A
(Homo sapiens (Human)) | BDBM50389232
(CHEMBL2063322)Show SMILES CCOC(=O)NCc1ccc(cc1)-c1cc(NC(=O)c2ccc(cc2)N2CCN(C)CC2)[nH]n1 Show InChI InChI=1S/C25H30N6O3/c1-3-34-25(33)26-17-18-4-6-19(7-5-18)22-16-23(29-28-22)27-24(32)20-8-10-21(11-9-20)31-14-12-30(2)13-15-31/h4-11,16H,3,12-15,17H2,1-2H3,(H,26,33)(H2,27,28,29,32) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
National Health Research Institutes
Curated by ChEMBL
| Assay Description Inhibition of Aurora A |
Bioorg Med Chem Lett 22: 4654-9 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.116 BindingDB Entry DOI: 10.7270/Q2XS5WGV |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50389232
(CHEMBL2063322)Show SMILES CCOC(=O)NCc1ccc(cc1)-c1cc(NC(=O)c2ccc(cc2)N2CCN(C)CC2)[nH]n1 Show InChI InChI=1S/C25H30N6O3/c1-3-34-25(33)26-17-18-4-6-19(7-5-18)22-16-23(29-28-22)27-24(32)20-8-10-21(11-9-20)31-14-12-30(2)13-15-31/h4-11,16H,3,12-15,17H2,1-2H3,(H,26,33)(H2,27,28,29,32) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 560 | n/a | n/a | n/a | n/a | n/a | n/a |
National Health Research Institutes
Curated by ChEMBL
| Assay Description Inhibition of VEGFR2 |
Bioorg Med Chem Lett 22: 4654-9 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.116 BindingDB Entry DOI: 10.7270/Q2XS5WGV |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM50389232
(CHEMBL2063322)Show SMILES CCOC(=O)NCc1ccc(cc1)-c1cc(NC(=O)c2ccc(cc2)N2CCN(C)CC2)[nH]n1 Show InChI InChI=1S/C25H30N6O3/c1-3-34-25(33)26-17-18-4-6-19(7-5-18)22-16-23(29-28-22)27-24(32)20-8-10-21(11-9-20)31-14-12-30(2)13-15-31/h4-11,16H,3,12-15,17H2,1-2H3,(H,26,33)(H2,27,28,29,32) | PDB MMDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
National Health Research Institutes
Curated by ChEMBL
| Assay Description Inhibition of VEGFR1 |
Bioorg Med Chem Lett 22: 4654-9 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.116 BindingDB Entry DOI: 10.7270/Q2XS5WGV |
More data for this Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50389232
(CHEMBL2063322)Show SMILES CCOC(=O)NCc1ccc(cc1)-c1cc(NC(=O)c2ccc(cc2)N2CCN(C)CC2)[nH]n1 Show InChI InChI=1S/C25H30N6O3/c1-3-34-25(33)26-17-18-4-6-19(7-5-18)22-16-23(29-28-22)27-24(32)20-8-10-21(11-9-20)31-14-12-30(2)13-15-31/h4-11,16H,3,12-15,17H2,1-2H3,(H,26,33)(H2,27,28,29,32) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
National Health Research Institutes
Curated by ChEMBL
| Assay Description Inhibition of wild type FLT3 |
Bioorg Med Chem Lett 22: 4654-9 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.116 BindingDB Entry DOI: 10.7270/Q2XS5WGV |
More data for this Ligand-Target Pair | |