Found 4 hits for monomerid = 50389237 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Aurora kinase A
(Homo sapiens (Human)) | BDBM50389237
(CHEMBL2063327)Show SMILES O=C(NCc1ccc(cc1)-c1cc(NC(=O)c2ccc(OCCCN3CCCC3)cc2)[nH]n1)OCc1ccccc1 Show InChI InChI=1S/C32H35N5O4/c38-31(27-13-15-28(16-14-27)40-20-6-19-37-17-4-5-18-37)34-30-21-29(35-36-30)26-11-9-24(10-12-26)22-33-32(39)41-23-25-7-2-1-3-8-25/h1-3,7-16,21H,4-6,17-20,22-23H2,(H,33,39)(H2,34,35,36,38) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
National Health Research Institutes
Curated by ChEMBL
| Assay Description Inhibition of Aurora A |
Bioorg Med Chem Lett 22: 4654-9 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.116 BindingDB Entry DOI: 10.7270/Q2XS5WGV |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50389237
(CHEMBL2063327)Show SMILES O=C(NCc1ccc(cc1)-c1cc(NC(=O)c2ccc(OCCCN3CCCC3)cc2)[nH]n1)OCc1ccccc1 Show InChI InChI=1S/C32H35N5O4/c38-31(27-13-15-28(16-14-27)40-20-6-19-37-17-4-5-18-37)34-30-21-29(35-36-30)26-11-9-24(10-12-26)22-33-32(39)41-23-25-7-2-1-3-8-25/h1-3,7-16,21H,4-6,17-20,22-23H2,(H,33,39)(H2,34,35,36,38) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 240 | n/a | n/a | n/a | n/a | n/a | n/a |
National Health Research Institutes
Curated by ChEMBL
| Assay Description Inhibition of VEGFR2 |
Bioorg Med Chem Lett 22: 4654-9 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.116 BindingDB Entry DOI: 10.7270/Q2XS5WGV |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM50389237
(CHEMBL2063327)Show SMILES O=C(NCc1ccc(cc1)-c1cc(NC(=O)c2ccc(OCCCN3CCCC3)cc2)[nH]n1)OCc1ccccc1 Show InChI InChI=1S/C32H35N5O4/c38-31(27-13-15-28(16-14-27)40-20-6-19-37-17-4-5-18-37)34-30-21-29(35-36-30)26-11-9-24(10-12-26)22-33-32(39)41-23-25-7-2-1-3-8-25/h1-3,7-16,21H,4-6,17-20,22-23H2,(H,33,39)(H2,34,35,36,38) | PDB MMDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | n/a |
National Health Research Institutes
Curated by ChEMBL
| Assay Description Inhibition of VEGFR1 |
Bioorg Med Chem Lett 22: 4654-9 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.116 BindingDB Entry DOI: 10.7270/Q2XS5WGV |
More data for this Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50389237
(CHEMBL2063327)Show SMILES O=C(NCc1ccc(cc1)-c1cc(NC(=O)c2ccc(OCCCN3CCCC3)cc2)[nH]n1)OCc1ccccc1 Show InChI InChI=1S/C32H35N5O4/c38-31(27-13-15-28(16-14-27)40-20-6-19-37-17-4-5-18-37)34-30-21-29(35-36-30)26-11-9-24(10-12-26)22-33-32(39)41-23-25-7-2-1-3-8-25/h1-3,7-16,21H,4-6,17-20,22-23H2,(H,33,39)(H2,34,35,36,38) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
National Health Research Institutes
Curated by ChEMBL
| Assay Description Inhibition of wild type FLT3 |
Bioorg Med Chem Lett 22: 4654-9 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.116 BindingDB Entry DOI: 10.7270/Q2XS5WGV |
More data for this Ligand-Target Pair | |