BDBM50389703 CHEMBL2070075::US10544104, Compound 148::US9765037, Compound 148

SMILES: CCOc1ccc2cc(ccc2c1)-c1nn(C2CCN(C)CC2)c2ncnc(N)c12

InChI Key: InChIKey=OKZQYDCLJOBEOA-UHFFFAOYSA-N

Data: 9 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50389703   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase ABL1 (Homo sapiens (Human))	BDBM50389703 (CHEMBL2070075 | US10544104, Compound 148 | US97650...) Show SMILES CCOc1ccc2cc(ccc2c1)-c1nn(C2CCN(C)CC2)c2ncnc(N)c12 Show InChI InChI=1S/C23H26N6O/c1-3-30-19-7-6-15-12-17(5-4-16(15)13-19)21-20-22(24)25-14-26-23(20)29(27-21)18-8-10-28(2)11-9-18/h4-7,12-14,18H,3,8-11H2,1-2H3,(H2,24,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Washington Curated by ChEMBL					Assay Description Inhibition of human ABL using EAIYAAPFAKKK-OH as substrate by phosphorimaging method				J Med Chem 55: 2416-26 (2012) Article DOI: 10.1021/jm201713h BindingDB Entry DOI: 10.7270/Q2P2706V
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM50389703 (CHEMBL2070075 | US10544104, Compound 148 | US97650...) Show SMILES CCOc1ccc2cc(ccc2c1)-c1nn(C2CCN(C)CC2)c2ncnc(N)c12 Show InChI InChI=1S/C23H26N6O/c1-3-30-19-7-6-15-12-17(5-4-16(15)13-19)21-20-22(24)25-14-26-23(20)29(27-21)18-8-10-28(2)11-9-18/h4-7,12-14,18H,3,8-11H2,1-2H3,(H2,24,25,26)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
University of Washington Curated by ChEMBL					Assay Description Inhibition of human LCK using Ac-EIYGEFKKK-OH as substrate after 60 mins				J Med Chem 55: 2416-26 (2012) Article DOI: 10.1021/jm201713h BindingDB Entry DOI: 10.7270/Q2P2706V
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50389703 (CHEMBL2070075 | US10544104, Compound 148 | US97650...) Show SMILES CCOc1ccc2cc(ccc2c1)-c1nn(C2CCN(C)CC2)c2ncnc(N)c12 Show InChI InChI=1S/C23H26N6O/c1-3-30-19-7-6-15-12-17(5-4-16(15)13-19)21-20-22(24)25-14-26-23(20)29(27-21)18-8-10-28(2)11-9-18/h4-7,12-14,18H,3,8-11H2,1-2H3,(H2,24,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Washington Curated by ChEMBL					Assay Description Inhibition of human p38alpha using myelin basic protein as substrate after 180 mins				J Med Chem 55: 2416-26 (2012) Article DOI: 10.1021/jm201713h BindingDB Entry DOI: 10.7270/Q2P2706V
					More data for this Ligand-Target Pair
Ephrin type-A receptor 3 (EPHA3) (Homo sapiens (Human))	BDBM50389703 (CHEMBL2070075 | US10544104, Compound 148 | US97650...) Show SMILES CCOc1ccc2cc(ccc2c1)-c1nn(C2CCN(C)CC2)c2ncnc(N)c12 Show InChI InChI=1S/C23H26N6O/c1-3-30-19-7-6-15-12-17(5-4-16(15)13-19)21-20-22(24)25-14-26-23(20)29(27-21)18-8-10-28(2)11-9-18/h4-7,12-14,18H,3,8-11H2,1-2H3,(H2,24,25,26)	PDB MMDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Washington Curated by ChEMBL					Assay Description Inhibition of human EPHA3 using myelin basic protein as substrate after 120 mins				J Med Chem 55: 2416-26 (2012) Article DOI: 10.1021/jm201713h BindingDB Entry DOI: 10.7270/Q2P2706V
					More data for this Ligand-Target Pair
Calmodulin/Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM50389703 (CHEMBL2070075 | US10544104, Compound 148 | US97650...) Show SMILES CCOc1ccc2cc(ccc2c1)-c1nn(C2CCN(C)CC2)c2ncnc(N)c12 Show InChI InChI=1S/C23H26N6O/c1-3-30-19-7-6-15-12-17(5-4-16(15)13-19)21-20-22(24)25-14-26-23(20)29(27-21)18-8-10-28(2)11-9-18/h4-7,12-14,18H,3,8-11H2,1-2H3,(H2,24,25,26)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5.58E+3	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR CO US Patent					Assay Description Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...				US Patent US10544104 (2020) BindingDB Entry DOI: 10.7270/Q2D79DSF
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50389703 (CHEMBL2070075 | US10544104, Compound 148 | US97650...) Show SMILES CCOc1ccc2cc(ccc2c1)-c1nn(C2CCN(C)CC2)c2ncnc(N)c12 Show InChI InChI=1S/C23H26N6O/c1-3-30-19-7-6-15-12-17(5-4-16(15)13-19)21-20-22(24)25-14-26-23(20)29(27-21)18-8-10-28(2)11-9-18/h4-7,12-14,18H,3,8-11H2,1-2H3,(H2,24,25,26)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Washington Curated by ChEMBL					Assay Description Inhibition of human EGFR using poly glu-Tyr as substrate after 30 mins				J Med Chem 55: 2416-26 (2012) Article DOI: 10.1021/jm201713h BindingDB Entry DOI: 10.7270/Q2P2706V
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM50389703 (CHEMBL2070075 | US10544104, Compound 148 | US97650...) Show SMILES CCOc1ccc2cc(ccc2c1)-c1nn(C2CCN(C)CC2)c2ncnc(N)c12 Show InChI InChI=1S/C23H26N6O/c1-3-30-19-7-6-15-12-17(5-4-16(15)13-19)21-20-22(24)25-14-26-23(20)29(27-21)18-8-10-28(2)11-9-18/h4-7,12-14,18H,3,8-11H2,1-2H3,(H2,24,25,26)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Washington Curated by ChEMBL					Assay Description Inhibition of human SRC using Ac-EIYGEFKKK-OH as substrate after 60 mins by phosphorimaging method				J Med Chem 55: 2416-26 (2012) Article DOI: 10.1021/jm201713h BindingDB Entry DOI: 10.7270/Q2P2706V
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM50389703 (CHEMBL2070075 | US10544104, Compound 148 | US97650...) Show SMILES CCOc1ccc2cc(ccc2c1)-c1nn(C2CCN(C)CC2)c2ncnc(N)c12 Show InChI InChI=1S/C23H26N6O/c1-3-30-19-7-6-15-12-17(5-4-16(15)13-19)21-20-22(24)25-14-26-23(20)29(27-21)18-8-10-28(2)11-9-18/h4-7,12-14,18H,3,8-11H2,1-2H3,(H2,24,25,26)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5.58E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Washington Through its Center for Commercialization US Patent					Assay Description Inhibition of human tyrosine kinases.				US Patent US9765037 (2017) BindingDB Entry DOI: 10.7270/Q2B56MVC
					More data for this Ligand-Target Pair
Tyrosine-protein kinase CSK (Homo sapiens (Human))	BDBM50389703 (CHEMBL2070075 | US10544104, Compound 148 | US97650...) Show SMILES CCOc1ccc2cc(ccc2c1)-c1nn(C2CCN(C)CC2)c2ncnc(N)c12 Show InChI InChI=1S/C23H26N6O/c1-3-30-19-7-6-15-12-17(5-4-16(15)13-19)21-20-22(24)25-14-26-23(20)29(27-21)18-8-10-28(2)11-9-18/h4-7,12-14,18H,3,8-11H2,1-2H3,(H2,24,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Washington Curated by ChEMBL					Assay Description Inhibition of human CSK using Ac-KKKKEEIYFFF-OH as substrate after 180 mins				J Med Chem 55: 2416-26 (2012) Article DOI: 10.1021/jm201713h BindingDB Entry DOI: 10.7270/Q2P2706V
					More data for this Ligand-Target Pair