Found 5 hits for monomerid = 50389780 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50389780
(CHEMBL2069317)Show SMILES CCCC[C@H](NC(=O)[C@H](CN(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCc1nnn[nH]1)C(=O)N[C@H]1CCC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O)C(N)=O |r,wU:35.38,26.32,78.79,128.138,117.121,106.110,88.142,wD:16.23,8.12,4.4,92.94,130.135,(42.02,-50.97,;42.81,-49.65,;42.06,-48.29,;42.86,-46.97,;42.11,-45.63,;40.57,-45.63,;39.83,-44.24,;40.61,-42.94,;38.28,-44.24,;37.49,-45.55,;38.24,-46.9,;37.44,-48.22,;39.78,-46.9,;37.53,-42.88,;38.33,-41.56,;39.87,-41.56,;37.58,-40.22,;36.04,-40.22,;35.25,-41.51,;35.85,-42.93,;34.69,-43.95,;33.37,-43.16,;33.71,-41.66,;38.37,-38.9,;37.62,-37.55,;36.08,-37.55,;38.41,-36.23,;39.95,-36.23,;40.75,-34.96,;42.28,-34.96,;43.03,-36.31,;43.08,-33.64,;37.66,-34.88,;38.45,-33.56,;39.99,-33.56,;37.71,-32.22,;38.5,-30.9,;40.04,-30.9,;36.16,-32.22,;35.42,-30.85,;36.21,-29.53,;33.88,-30.85,;33.13,-29.47,;33.92,-28.15,;35.46,-28.15,;33.18,-26.81,;33.97,-25.49,;35.51,-25.49,;36.26,-26.86,;37.8,-26.86,;38.54,-28.24,;40.08,-28.24,;40.88,-26.97,;42.42,-26.97,;43.16,-28.32,;43.21,-25.65,;44.75,-25.65,;45.5,-27.03,;47.04,-27.03,;47.78,-28.4,;49.32,-28.4,;50.07,-29.77,;51.61,-29.77,;52.35,-31.15,;53.89,-31.15,;54.69,-29.86,;53.94,-28.51,;54.73,-27.19,;53.99,-25.84,;54.78,-24.52,;54.03,-23.17,;52.5,-22.99,;52.21,-21.48,;53.55,-20.73,;54.69,-21.79,;42.9,-44.31,;42.15,-42.96,;44.45,-44.31,;45.23,-43.02,;44.66,-41.59,;45.69,-39.96,;45.69,-31.65,;44.6,-30.56,;67.64,-31.65,;67.64,-36.79,;66.27,-37.55,;66.27,-39.08,;64.91,-39.84,;64.91,-41.38,;63.56,-42.12,;62.24,-41.33,;62.24,-39.8,;60.89,-42.09,;60.89,-43.63,;62.19,-44.41,;63.6,-43.81,;64.62,-44.97,;63.83,-46.29,;64.29,-47.76,;63.24,-48.89,;61.73,-48.55,;61.29,-47.08,;62.33,-45.95,;59.57,-41.3,;58.23,-42.05,;58.23,-43.59,;56.9,-41.26,;56.9,-39.72,;58.27,-38.97,;58.27,-37.43,;59.66,-36.68,;59.66,-35.14,;58.34,-34.35,;61,-34.39,;55.56,-42.01,;54.23,-41.23,;54.23,-39.68,;52.89,-41.97,;52.89,-43.51,;54.19,-44.3,;55.54,-43.55,;56.86,-44.34,;56.86,-45.88,;55.49,-46.63,;54.19,-45.84,;51.57,-41.18,;50.23,-41.93,;50.23,-43.47,;48.91,-41.14,;49.01,-39.59,;47.36,-39.23,;46.69,-37.7,;46.52,-40.68,;47.63,-41.95,;46.76,-43.23,;47.42,-44.61,;66.23,-42.17,;67.57,-41.42,;66.23,-43.7,)| Show InChI InChI=1S/C92H143N27O20/c1-4-5-30-65(82(128)109-68-37-39-78(124)98-40-25-24-32-64(81(94)127)105-86(132)70(47-59-50-101-63-31-23-22-29-62(59)63)110-83(129)66(33-26-41-100-92(95)96)106-85(131)69(46-58-27-18-17-19-28-58)112-90(136)74-49-61(121)53-119(74)91(68)137)107-88(134)72(54-118(2)3)113-87(133)71(48-60-51-97-57-103-60)111-84(130)67(36-38-75(93)122)108-89(135)73(55-120)104-79(125)52-102-80(126)56-139-45-44-138-43-42-99-77(123)35-21-16-14-12-10-8-6-7-9-11-13-15-20-34-76-114-116-117-115-76/h17-19,22-23,27-29,31,50-51,57,61,64-74,101,120-121H,4-16,20-21,24-26,30,32-49,52-56H2,1-3H3,(H2,93,122)(H2,94,127)(H,97,103)(H,98,124)(H,99,123)(H,102,126)(H,104,125)(H,105,132)(H,106,131)(H,107,134)(H,108,135)(H,109,128)(H,110,129)(H,111,130)(H,112,136)(H,113,133)(H4,95,96,100)(H,114,115,116,117)/t61-,64+,65+,66+,67+,68+,69-,70+,71+,72+,73+,74+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.130 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Displacement of [125I]-NAD-alpha-MSH from MC4 receptor after 2 hrs by gamma counting in presence of ovalbumin |
J Med Chem 55: 1969-77 (2012)
Article DOI: 10.1021/jm201489a
BindingDB Entry DOI: 10.7270/Q2DN464P |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 5 (MC5R)
(Homo sapiens (Human)) | BDBM50389780
(CHEMBL2069317)Show SMILES CCCC[C@H](NC(=O)[C@H](CN(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCc1nnn[nH]1)C(=O)N[C@H]1CCC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O)C(N)=O |r,wU:35.38,26.32,78.79,128.138,117.121,106.110,88.142,wD:16.23,8.12,4.4,92.94,130.135,(42.02,-50.97,;42.81,-49.65,;42.06,-48.29,;42.86,-46.97,;42.11,-45.63,;40.57,-45.63,;39.83,-44.24,;40.61,-42.94,;38.28,-44.24,;37.49,-45.55,;38.24,-46.9,;37.44,-48.22,;39.78,-46.9,;37.53,-42.88,;38.33,-41.56,;39.87,-41.56,;37.58,-40.22,;36.04,-40.22,;35.25,-41.51,;35.85,-42.93,;34.69,-43.95,;33.37,-43.16,;33.71,-41.66,;38.37,-38.9,;37.62,-37.55,;36.08,-37.55,;38.41,-36.23,;39.95,-36.23,;40.75,-34.96,;42.28,-34.96,;43.03,-36.31,;43.08,-33.64,;37.66,-34.88,;38.45,-33.56,;39.99,-33.56,;37.71,-32.22,;38.5,-30.9,;40.04,-30.9,;36.16,-32.22,;35.42,-30.85,;36.21,-29.53,;33.88,-30.85,;33.13,-29.47,;33.92,-28.15,;35.46,-28.15,;33.18,-26.81,;33.97,-25.49,;35.51,-25.49,;36.26,-26.86,;37.8,-26.86,;38.54,-28.24,;40.08,-28.24,;40.88,-26.97,;42.42,-26.97,;43.16,-28.32,;43.21,-25.65,;44.75,-25.65,;45.5,-27.03,;47.04,-27.03,;47.78,-28.4,;49.32,-28.4,;50.07,-29.77,;51.61,-29.77,;52.35,-31.15,;53.89,-31.15,;54.69,-29.86,;53.94,-28.51,;54.73,-27.19,;53.99,-25.84,;54.78,-24.52,;54.03,-23.17,;52.5,-22.99,;52.21,-21.48,;53.55,-20.73,;54.69,-21.79,;42.9,-44.31,;42.15,-42.96,;44.45,-44.31,;45.23,-43.02,;44.66,-41.59,;45.69,-39.96,;45.69,-31.65,;44.6,-30.56,;67.64,-31.65,;67.64,-36.79,;66.27,-37.55,;66.27,-39.08,;64.91,-39.84,;64.91,-41.38,;63.56,-42.12,;62.24,-41.33,;62.24,-39.8,;60.89,-42.09,;60.89,-43.63,;62.19,-44.41,;63.6,-43.81,;64.62,-44.97,;63.83,-46.29,;64.29,-47.76,;63.24,-48.89,;61.73,-48.55,;61.29,-47.08,;62.33,-45.95,;59.57,-41.3,;58.23,-42.05,;58.23,-43.59,;56.9,-41.26,;56.9,-39.72,;58.27,-38.97,;58.27,-37.43,;59.66,-36.68,;59.66,-35.14,;58.34,-34.35,;61,-34.39,;55.56,-42.01,;54.23,-41.23,;54.23,-39.68,;52.89,-41.97,;52.89,-43.51,;54.19,-44.3,;55.54,-43.55,;56.86,-44.34,;56.86,-45.88,;55.49,-46.63,;54.19,-45.84,;51.57,-41.18,;50.23,-41.93,;50.23,-43.47,;48.91,-41.14,;49.01,-39.59,;47.36,-39.23,;46.69,-37.7,;46.52,-40.68,;47.63,-41.95,;46.76,-43.23,;47.42,-44.61,;66.23,-42.17,;67.57,-41.42,;66.23,-43.7,)| Show InChI InChI=1S/C92H143N27O20/c1-4-5-30-65(82(128)109-68-37-39-78(124)98-40-25-24-32-64(81(94)127)105-86(132)70(47-59-50-101-63-31-23-22-29-62(59)63)110-83(129)66(33-26-41-100-92(95)96)106-85(131)69(46-58-27-18-17-19-28-58)112-90(136)74-49-61(121)53-119(74)91(68)137)107-88(134)72(54-118(2)3)113-87(133)71(48-60-51-97-57-103-60)111-84(130)67(36-38-75(93)122)108-89(135)73(55-120)104-79(125)52-102-80(126)56-139-45-44-138-43-42-99-77(123)35-21-16-14-12-10-8-6-7-9-11-13-15-20-34-76-114-116-117-115-76/h17-19,22-23,27-29,31,50-51,57,61,64-74,101,120-121H,4-16,20-21,24-26,30,32-49,52-56H2,1-3H3,(H2,93,122)(H2,94,127)(H,97,103)(H,98,124)(H,99,123)(H,102,126)(H,104,125)(H,105,132)(H,106,131)(H,107,134)(H,108,135)(H,109,128)(H,110,129)(H,111,130)(H,112,136)(H,113,133)(H4,95,96,100)(H,114,115,116,117)/t61-,64+,65+,66+,67+,68+,69-,70+,71+,72+,73+,74+/m1/s1 | UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 2.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbumin |
J Med Chem 55: 1969-77 (2012)
Article DOI: 10.1021/jm201489a
BindingDB Entry DOI: 10.7270/Q2DN464P |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 3
(Homo sapiens (Human)) | BDBM50389780
(CHEMBL2069317)Show SMILES CCCC[C@H](NC(=O)[C@H](CN(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCc1nnn[nH]1)C(=O)N[C@H]1CCC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O)C(N)=O |r,wU:35.38,26.32,78.79,128.138,117.121,106.110,88.142,wD:16.23,8.12,4.4,92.94,130.135,(42.02,-50.97,;42.81,-49.65,;42.06,-48.29,;42.86,-46.97,;42.11,-45.63,;40.57,-45.63,;39.83,-44.24,;40.61,-42.94,;38.28,-44.24,;37.49,-45.55,;38.24,-46.9,;37.44,-48.22,;39.78,-46.9,;37.53,-42.88,;38.33,-41.56,;39.87,-41.56,;37.58,-40.22,;36.04,-40.22,;35.25,-41.51,;35.85,-42.93,;34.69,-43.95,;33.37,-43.16,;33.71,-41.66,;38.37,-38.9,;37.62,-37.55,;36.08,-37.55,;38.41,-36.23,;39.95,-36.23,;40.75,-34.96,;42.28,-34.96,;43.03,-36.31,;43.08,-33.64,;37.66,-34.88,;38.45,-33.56,;39.99,-33.56,;37.71,-32.22,;38.5,-30.9,;40.04,-30.9,;36.16,-32.22,;35.42,-30.85,;36.21,-29.53,;33.88,-30.85,;33.13,-29.47,;33.92,-28.15,;35.46,-28.15,;33.18,-26.81,;33.97,-25.49,;35.51,-25.49,;36.26,-26.86,;37.8,-26.86,;38.54,-28.24,;40.08,-28.24,;40.88,-26.97,;42.42,-26.97,;43.16,-28.32,;43.21,-25.65,;44.75,-25.65,;45.5,-27.03,;47.04,-27.03,;47.78,-28.4,;49.32,-28.4,;50.07,-29.77,;51.61,-29.77,;52.35,-31.15,;53.89,-31.15,;54.69,-29.86,;53.94,-28.51,;54.73,-27.19,;53.99,-25.84,;54.78,-24.52,;54.03,-23.17,;52.5,-22.99,;52.21,-21.48,;53.55,-20.73,;54.69,-21.79,;42.9,-44.31,;42.15,-42.96,;44.45,-44.31,;45.23,-43.02,;44.66,-41.59,;45.69,-39.96,;45.69,-31.65,;44.6,-30.56,;67.64,-31.65,;67.64,-36.79,;66.27,-37.55,;66.27,-39.08,;64.91,-39.84,;64.91,-41.38,;63.56,-42.12,;62.24,-41.33,;62.24,-39.8,;60.89,-42.09,;60.89,-43.63,;62.19,-44.41,;63.6,-43.81,;64.62,-44.97,;63.83,-46.29,;64.29,-47.76,;63.24,-48.89,;61.73,-48.55,;61.29,-47.08,;62.33,-45.95,;59.57,-41.3,;58.23,-42.05,;58.23,-43.59,;56.9,-41.26,;56.9,-39.72,;58.27,-38.97,;58.27,-37.43,;59.66,-36.68,;59.66,-35.14,;58.34,-34.35,;61,-34.39,;55.56,-42.01,;54.23,-41.23,;54.23,-39.68,;52.89,-41.97,;52.89,-43.51,;54.19,-44.3,;55.54,-43.55,;56.86,-44.34,;56.86,-45.88,;55.49,-46.63,;54.19,-45.84,;51.57,-41.18,;50.23,-41.93,;50.23,-43.47,;48.91,-41.14,;49.01,-39.59,;47.36,-39.23,;46.69,-37.7,;46.52,-40.68,;47.63,-41.95,;46.76,-43.23,;47.42,-44.61,;66.23,-42.17,;67.57,-41.42,;66.23,-43.7,)| Show InChI InChI=1S/C92H143N27O20/c1-4-5-30-65(82(128)109-68-37-39-78(124)98-40-25-24-32-64(81(94)127)105-86(132)70(47-59-50-101-63-31-23-22-29-62(59)63)110-83(129)66(33-26-41-100-92(95)96)106-85(131)69(46-58-27-18-17-19-28-58)112-90(136)74-49-61(121)53-119(74)91(68)137)107-88(134)72(54-118(2)3)113-87(133)71(48-60-51-97-57-103-60)111-84(130)67(36-38-75(93)122)108-89(135)73(55-120)104-79(125)52-102-80(126)56-139-45-44-138-43-42-99-77(123)35-21-16-14-12-10-8-6-7-9-11-13-15-20-34-76-114-116-117-115-76/h17-19,22-23,27-29,31,50-51,57,61,64-74,101,120-121H,4-16,20-21,24-26,30,32-49,52-56H2,1-3H3,(H2,93,122)(H2,94,127)(H,97,103)(H,98,124)(H,99,123)(H,102,126)(H,104,125)(H,105,132)(H,106,131)(H,107,134)(H,108,135)(H,109,128)(H,110,129)(H,111,130)(H,112,136)(H,113,133)(H4,95,96,100)(H,114,115,116,117)/t61-,64+,65+,66+,67+,68+,69-,70+,71+,72+,73+,74+/m1/s1 | UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 11 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbumin |
J Med Chem 55: 1969-77 (2012)
Article DOI: 10.1021/jm201489a
BindingDB Entry DOI: 10.7270/Q2DN464P |
More data for this
Ligand-Target Pair | |
Melanocyte-stimulating hormone receptor
(Homo sapiens (Human)) | BDBM50389780
(CHEMBL2069317)Show SMILES CCCC[C@H](NC(=O)[C@H](CN(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCc1nnn[nH]1)C(=O)N[C@H]1CCC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O)C(N)=O |r,wU:35.38,26.32,78.79,128.138,117.121,106.110,88.142,wD:16.23,8.12,4.4,92.94,130.135,(42.02,-50.97,;42.81,-49.65,;42.06,-48.29,;42.86,-46.97,;42.11,-45.63,;40.57,-45.63,;39.83,-44.24,;40.61,-42.94,;38.28,-44.24,;37.49,-45.55,;38.24,-46.9,;37.44,-48.22,;39.78,-46.9,;37.53,-42.88,;38.33,-41.56,;39.87,-41.56,;37.58,-40.22,;36.04,-40.22,;35.25,-41.51,;35.85,-42.93,;34.69,-43.95,;33.37,-43.16,;33.71,-41.66,;38.37,-38.9,;37.62,-37.55,;36.08,-37.55,;38.41,-36.23,;39.95,-36.23,;40.75,-34.96,;42.28,-34.96,;43.03,-36.31,;43.08,-33.64,;37.66,-34.88,;38.45,-33.56,;39.99,-33.56,;37.71,-32.22,;38.5,-30.9,;40.04,-30.9,;36.16,-32.22,;35.42,-30.85,;36.21,-29.53,;33.88,-30.85,;33.13,-29.47,;33.92,-28.15,;35.46,-28.15,;33.18,-26.81,;33.97,-25.49,;35.51,-25.49,;36.26,-26.86,;37.8,-26.86,;38.54,-28.24,;40.08,-28.24,;40.88,-26.97,;42.42,-26.97,;43.16,-28.32,;43.21,-25.65,;44.75,-25.65,;45.5,-27.03,;47.04,-27.03,;47.78,-28.4,;49.32,-28.4,;50.07,-29.77,;51.61,-29.77,;52.35,-31.15,;53.89,-31.15,;54.69,-29.86,;53.94,-28.51,;54.73,-27.19,;53.99,-25.84,;54.78,-24.52,;54.03,-23.17,;52.5,-22.99,;52.21,-21.48,;53.55,-20.73,;54.69,-21.79,;42.9,-44.31,;42.15,-42.96,;44.45,-44.31,;45.23,-43.02,;44.66,-41.59,;45.69,-39.96,;45.69,-31.65,;44.6,-30.56,;67.64,-31.65,;67.64,-36.79,;66.27,-37.55,;66.27,-39.08,;64.91,-39.84,;64.91,-41.38,;63.56,-42.12,;62.24,-41.33,;62.24,-39.8,;60.89,-42.09,;60.89,-43.63,;62.19,-44.41,;63.6,-43.81,;64.62,-44.97,;63.83,-46.29,;64.29,-47.76,;63.24,-48.89,;61.73,-48.55,;61.29,-47.08,;62.33,-45.95,;59.57,-41.3,;58.23,-42.05,;58.23,-43.59,;56.9,-41.26,;56.9,-39.72,;58.27,-38.97,;58.27,-37.43,;59.66,-36.68,;59.66,-35.14,;58.34,-34.35,;61,-34.39,;55.56,-42.01,;54.23,-41.23,;54.23,-39.68,;52.89,-41.97,;52.89,-43.51,;54.19,-44.3,;55.54,-43.55,;56.86,-44.34,;56.86,-45.88,;55.49,-46.63,;54.19,-45.84,;51.57,-41.18,;50.23,-41.93,;50.23,-43.47,;48.91,-41.14,;49.01,-39.59,;47.36,-39.23,;46.69,-37.7,;46.52,-40.68,;47.63,-41.95,;46.76,-43.23,;47.42,-44.61,;66.23,-42.17,;67.57,-41.42,;66.23,-43.7,)| Show InChI InChI=1S/C92H143N27O20/c1-4-5-30-65(82(128)109-68-37-39-78(124)98-40-25-24-32-64(81(94)127)105-86(132)70(47-59-50-101-63-31-23-22-29-62(59)63)110-83(129)66(33-26-41-100-92(95)96)106-85(131)69(46-58-27-18-17-19-28-58)112-90(136)74-49-61(121)53-119(74)91(68)137)107-88(134)72(54-118(2)3)113-87(133)71(48-60-51-97-57-103-60)111-84(130)67(36-38-75(93)122)108-89(135)73(55-120)104-79(125)52-102-80(126)56-139-45-44-138-43-42-99-77(123)35-21-16-14-12-10-8-6-7-9-11-13-15-20-34-76-114-116-117-115-76/h17-19,22-23,27-29,31,50-51,57,61,64-74,101,120-121H,4-16,20-21,24-26,30,32-49,52-56H2,1-3H3,(H2,93,122)(H2,94,127)(H,97,103)(H,98,124)(H,99,123)(H,102,126)(H,104,125)(H,105,132)(H,106,131)(H,107,134)(H,108,135)(H,109,128)(H,110,129)(H,111,130)(H,112,136)(H,113,133)(H4,95,96,100)(H,114,115,116,117)/t61-,64+,65+,66+,67+,68+,69-,70+,71+,72+,73+,74+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| 440 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Displacement of [125I]-NAD-alpha-MSH from human recombinant MC1 receptor expressed in BHK570 cells after 90 mins in presence of ovalbumin |
J Med Chem 55: 1969-77 (2012)
Article DOI: 10.1021/jm201489a
BindingDB Entry DOI: 10.7270/Q2DN464P |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50389780
(CHEMBL2069317)Show SMILES CCCC[C@H](NC(=O)[C@H](CN(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCc1nnn[nH]1)C(=O)N[C@H]1CCC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O)C(N)=O |r,wU:35.38,26.32,78.79,128.138,117.121,106.110,88.142,wD:16.23,8.12,4.4,92.94,130.135,(42.02,-50.97,;42.81,-49.65,;42.06,-48.29,;42.86,-46.97,;42.11,-45.63,;40.57,-45.63,;39.83,-44.24,;40.61,-42.94,;38.28,-44.24,;37.49,-45.55,;38.24,-46.9,;37.44,-48.22,;39.78,-46.9,;37.53,-42.88,;38.33,-41.56,;39.87,-41.56,;37.58,-40.22,;36.04,-40.22,;35.25,-41.51,;35.85,-42.93,;34.69,-43.95,;33.37,-43.16,;33.71,-41.66,;38.37,-38.9,;37.62,-37.55,;36.08,-37.55,;38.41,-36.23,;39.95,-36.23,;40.75,-34.96,;42.28,-34.96,;43.03,-36.31,;43.08,-33.64,;37.66,-34.88,;38.45,-33.56,;39.99,-33.56,;37.71,-32.22,;38.5,-30.9,;40.04,-30.9,;36.16,-32.22,;35.42,-30.85,;36.21,-29.53,;33.88,-30.85,;33.13,-29.47,;33.92,-28.15,;35.46,-28.15,;33.18,-26.81,;33.97,-25.49,;35.51,-25.49,;36.26,-26.86,;37.8,-26.86,;38.54,-28.24,;40.08,-28.24,;40.88,-26.97,;42.42,-26.97,;43.16,-28.32,;43.21,-25.65,;44.75,-25.65,;45.5,-27.03,;47.04,-27.03,;47.78,-28.4,;49.32,-28.4,;50.07,-29.77,;51.61,-29.77,;52.35,-31.15,;53.89,-31.15,;54.69,-29.86,;53.94,-28.51,;54.73,-27.19,;53.99,-25.84,;54.78,-24.52,;54.03,-23.17,;52.5,-22.99,;52.21,-21.48,;53.55,-20.73,;54.69,-21.79,;42.9,-44.31,;42.15,-42.96,;44.45,-44.31,;45.23,-43.02,;44.66,-41.59,;45.69,-39.96,;45.69,-31.65,;44.6,-30.56,;67.64,-31.65,;67.64,-36.79,;66.27,-37.55,;66.27,-39.08,;64.91,-39.84,;64.91,-41.38,;63.56,-42.12,;62.24,-41.33,;62.24,-39.8,;60.89,-42.09,;60.89,-43.63,;62.19,-44.41,;63.6,-43.81,;64.62,-44.97,;63.83,-46.29,;64.29,-47.76,;63.24,-48.89,;61.73,-48.55,;61.29,-47.08,;62.33,-45.95,;59.57,-41.3,;58.23,-42.05,;58.23,-43.59,;56.9,-41.26,;56.9,-39.72,;58.27,-38.97,;58.27,-37.43,;59.66,-36.68,;59.66,-35.14,;58.34,-34.35,;61,-34.39,;55.56,-42.01,;54.23,-41.23,;54.23,-39.68,;52.89,-41.97,;52.89,-43.51,;54.19,-44.3,;55.54,-43.55,;56.86,-44.34,;56.86,-45.88,;55.49,-46.63,;54.19,-45.84,;51.57,-41.18,;50.23,-41.93,;50.23,-43.47,;48.91,-41.14,;49.01,-39.59,;47.36,-39.23,;46.69,-37.7,;46.52,-40.68,;47.63,-41.95,;46.76,-43.23,;47.42,-44.61,;66.23,-42.17,;67.57,-41.42,;66.23,-43.7,)| Show InChI InChI=1S/C92H143N27O20/c1-4-5-30-65(82(128)109-68-37-39-78(124)98-40-25-24-32-64(81(94)127)105-86(132)70(47-59-50-101-63-31-23-22-29-62(59)63)110-83(129)66(33-26-41-100-92(95)96)106-85(131)69(46-58-27-18-17-19-28-58)112-90(136)74-49-61(121)53-119(74)91(68)137)107-88(134)72(54-118(2)3)113-87(133)71(48-60-51-97-57-103-60)111-84(130)67(36-38-75(93)122)108-89(135)73(55-120)104-79(125)52-102-80(126)56-139-45-44-138-43-42-99-77(123)35-21-16-14-12-10-8-6-7-9-11-13-15-20-34-76-114-116-117-115-76/h17-19,22-23,27-29,31,50-51,57,61,64-74,101,120-121H,4-16,20-21,24-26,30,32-49,52-56H2,1-3H3,(H2,93,122)(H2,94,127)(H,97,103)(H,98,124)(H,99,123)(H,102,126)(H,104,125)(H,105,132)(H,106,131)(H,107,134)(H,108,135)(H,109,128)(H,110,129)(H,111,130)(H,112,136)(H,113,133)(H4,95,96,100)(H,114,115,116,117)/t61-,64+,65+,66+,67+,68+,69-,70+,71+,72+,73+,74+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 130 | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Agonist activity at human recombinant MC4 receptor expressed in BHK570 cells assessed as induction of cMAP accumulation in presence of 0.1% human ser... |
J Med Chem 55: 1969-77 (2012)
Article DOI: 10.1021/jm201489a
BindingDB Entry DOI: 10.7270/Q2DN464P |
More data for this
Ligand-Target Pair | |
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