Found 5 hits for monomerid = 50389781 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50389781
(CHEMBL2070254)Show SMILES CCCC[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCc1nnn[nH]1)C(=O)N[C@H]1CCC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O)C(N)=O |r,wU:37.42,28.33,83.83,133.142,122.125,111.114,93.146,wD:17.24,8.13,4.4,97.98,135.139,(40.6,-30.05,;41.4,-28.73,;40.65,-27.38,;41.45,-26.06,;40.69,-24.71,;39.16,-24.71,;38.41,-23.32,;39.2,-22.02,;36.87,-23.32,;36.08,-24.63,;36.82,-25.98,;36.03,-27.3,;34.49,-27.3,;36.78,-28.65,;36.12,-21.97,;36.91,-20.65,;38.45,-20.65,;36.16,-19.31,;34.62,-19.31,;33.88,-17.93,;32.34,-17.93,;31.59,-16.53,;30.05,-16.53,;29.3,-15.19,;29.26,-17.86,;36.95,-17.98,;36.2,-16.63,;34.67,-16.63,;36.99,-15.32,;38.54,-15.32,;39.33,-14.05,;40.87,-14.05,;41.61,-15.39,;41.66,-12.73,;36.25,-13.97,;37.04,-12.65,;38.58,-12.65,;36.29,-11.31,;37.08,-9.98,;38.62,-9.98,;39.41,-8.69,;40.95,-8.69,;38.07,-7.91,;34.75,-11.31,;34,-9.93,;34.79,-8.61,;32.46,-9.93,;31.71,-8.56,;32.51,-7.24,;34.05,-7.24,;31.76,-5.89,;32.56,-4.57,;34.1,-4.57,;34.84,-5.95,;36.38,-5.95,;37.13,-7.32,;38.67,-7.32,;39.46,-6.06,;41,-6.06,;41.75,-7.4,;41.79,-4.74,;43.33,-4.74,;44.08,-6.11,;45.62,-6.11,;46.37,-7.48,;47.91,-7.48,;48.65,-8.86,;50.19,-8.86,;50.94,-10.23,;52.48,-10.23,;53.27,-8.94,;52.53,-7.59,;53.32,-6.27,;52.57,-4.93,;53.37,-3.61,;52.62,-2.26,;51.08,-2.07,;50.8,-.57,;52.13,.19,;53.27,-.87,;41.49,-23.39,;40.74,-22.05,;43.03,-23.39,;43.82,-22.1,;43.24,-20.67,;44.27,-19.04,;44.27,-10.73,;43.18,-9.65,;66.22,-10.73,;66.22,-15.88,;64.85,-16.63,;64.85,-18.17,;63.49,-18.92,;63.49,-20.46,;62.14,-21.21,;60.82,-20.42,;60.82,-18.89,;59.48,-21.17,;59.48,-22.72,;60.77,-23.5,;62.19,-22.9,;63.21,-24.05,;62.42,-25.37,;62.87,-26.85,;61.82,-27.98,;60.32,-27.64,;59.87,-26.17,;60.91,-25.04,;58.15,-20.39,;56.81,-21.14,;56.81,-22.67,;55.48,-20.35,;55.48,-18.8,;56.85,-18.05,;56.85,-16.52,;58.24,-15.76,;58.24,-14.23,;56.92,-13.44,;59.59,-13.47,;54.14,-21.09,;52.82,-20.31,;52.82,-18.77,;51.48,-21.06,;51.48,-22.6,;52.77,-23.39,;54.12,-22.64,;55.44,-23.43,;55.44,-24.96,;54.08,-25.71,;52.77,-24.92,;50.16,-20.27,;48.81,-21.02,;48.81,-22.55,;47.49,-20.23,;47.59,-18.67,;45.95,-18.32,;45.27,-16.79,;45.1,-19.76,;46.21,-21.03,;45.35,-22.31,;46.01,-23.7,;64.81,-21.25,;66.16,-20.5,;64.81,-22.79,)| Show InChI InChI=1S/C94H146N26O24/c1-2-3-29-64(84(134)113-70-36-40-76(123)100-44-23-22-31-63(82(95)132)107-90(140)72(52-59-54-104-62-30-21-20-28-61(59)62)114-85(135)66(33-25-46-103-94(98)99)110-89(139)71(51-58-26-16-15-17-27-58)115-91(141)73-53-60(121)56-120(73)92(70)142)108-87(137)68(38-42-80(128)129)111-83(133)65(32-24-45-102-93(96)97)109-88(138)69(39-43-81(130)131)112-86(136)67(37-41-79(126)127)106-77(124)55-105-78(125)57-144-50-49-143-48-47-101-75(122)35-19-14-12-10-8-6-4-5-7-9-11-13-18-34-74-116-118-119-117-74/h15-17,20-21,26-28,30,54,60,63-73,104,121H,2-14,18-19,22-25,29,31-53,55-57H2,1H3,(H2,95,132)(H,100,123)(H,101,122)(H,105,125)(H,106,124)(H,107,140)(H,108,137)(H,109,138)(H,110,139)(H,111,133)(H,112,136)(H,113,134)(H,114,135)(H,115,141)(H,126,127)(H,128,129)(H,130,131)(H4,96,97,102)(H4,98,99,103)(H,116,117,118,119)/t60-,63+,64+,65+,66+,67+,68+,69+,70+,71-,72+,73+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 35 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Displacement of [125I]-NAD-alpha-MSH from MC4 receptor after 2 hrs by gamma counting in presence of ovalbumin |
J Med Chem 55: 1969-77 (2012)
Article DOI: 10.1021/jm201489a
BindingDB Entry DOI: 10.7270/Q2DN464P |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 5 (MC5R)
(Homo sapiens (Human)) | BDBM50389781
(CHEMBL2070254)Show SMILES CCCC[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCc1nnn[nH]1)C(=O)N[C@H]1CCC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O)C(N)=O |r,wU:37.42,28.33,83.83,133.142,122.125,111.114,93.146,wD:17.24,8.13,4.4,97.98,135.139,(40.6,-30.05,;41.4,-28.73,;40.65,-27.38,;41.45,-26.06,;40.69,-24.71,;39.16,-24.71,;38.41,-23.32,;39.2,-22.02,;36.87,-23.32,;36.08,-24.63,;36.82,-25.98,;36.03,-27.3,;34.49,-27.3,;36.78,-28.65,;36.12,-21.97,;36.91,-20.65,;38.45,-20.65,;36.16,-19.31,;34.62,-19.31,;33.88,-17.93,;32.34,-17.93,;31.59,-16.53,;30.05,-16.53,;29.3,-15.19,;29.26,-17.86,;36.95,-17.98,;36.2,-16.63,;34.67,-16.63,;36.99,-15.32,;38.54,-15.32,;39.33,-14.05,;40.87,-14.05,;41.61,-15.39,;41.66,-12.73,;36.25,-13.97,;37.04,-12.65,;38.58,-12.65,;36.29,-11.31,;37.08,-9.98,;38.62,-9.98,;39.41,-8.69,;40.95,-8.69,;38.07,-7.91,;34.75,-11.31,;34,-9.93,;34.79,-8.61,;32.46,-9.93,;31.71,-8.56,;32.51,-7.24,;34.05,-7.24,;31.76,-5.89,;32.56,-4.57,;34.1,-4.57,;34.84,-5.95,;36.38,-5.95,;37.13,-7.32,;38.67,-7.32,;39.46,-6.06,;41,-6.06,;41.75,-7.4,;41.79,-4.74,;43.33,-4.74,;44.08,-6.11,;45.62,-6.11,;46.37,-7.48,;47.91,-7.48,;48.65,-8.86,;50.19,-8.86,;50.94,-10.23,;52.48,-10.23,;53.27,-8.94,;52.53,-7.59,;53.32,-6.27,;52.57,-4.93,;53.37,-3.61,;52.62,-2.26,;51.08,-2.07,;50.8,-.57,;52.13,.19,;53.27,-.87,;41.49,-23.39,;40.74,-22.05,;43.03,-23.39,;43.82,-22.1,;43.24,-20.67,;44.27,-19.04,;44.27,-10.73,;43.18,-9.65,;66.22,-10.73,;66.22,-15.88,;64.85,-16.63,;64.85,-18.17,;63.49,-18.92,;63.49,-20.46,;62.14,-21.21,;60.82,-20.42,;60.82,-18.89,;59.48,-21.17,;59.48,-22.72,;60.77,-23.5,;62.19,-22.9,;63.21,-24.05,;62.42,-25.37,;62.87,-26.85,;61.82,-27.98,;60.32,-27.64,;59.87,-26.17,;60.91,-25.04,;58.15,-20.39,;56.81,-21.14,;56.81,-22.67,;55.48,-20.35,;55.48,-18.8,;56.85,-18.05,;56.85,-16.52,;58.24,-15.76,;58.24,-14.23,;56.92,-13.44,;59.59,-13.47,;54.14,-21.09,;52.82,-20.31,;52.82,-18.77,;51.48,-21.06,;51.48,-22.6,;52.77,-23.39,;54.12,-22.64,;55.44,-23.43,;55.44,-24.96,;54.08,-25.71,;52.77,-24.92,;50.16,-20.27,;48.81,-21.02,;48.81,-22.55,;47.49,-20.23,;47.59,-18.67,;45.95,-18.32,;45.27,-16.79,;45.1,-19.76,;46.21,-21.03,;45.35,-22.31,;46.01,-23.7,;64.81,-21.25,;66.16,-20.5,;64.81,-22.79,)| Show InChI InChI=1S/C94H146N26O24/c1-2-3-29-64(84(134)113-70-36-40-76(123)100-44-23-22-31-63(82(95)132)107-90(140)72(52-59-54-104-62-30-21-20-28-61(59)62)114-85(135)66(33-25-46-103-94(98)99)110-89(139)71(51-58-26-16-15-17-27-58)115-91(141)73-53-60(121)56-120(73)92(70)142)108-87(137)68(38-42-80(128)129)111-83(133)65(32-24-45-102-93(96)97)109-88(138)69(39-43-81(130)131)112-86(136)67(37-41-79(126)127)106-77(124)55-105-78(125)57-144-50-49-143-48-47-101-75(122)35-19-14-12-10-8-6-4-5-7-9-11-13-18-34-74-116-118-119-117-74/h15-17,20-21,26-28,30,54,60,63-73,104,121H,2-14,18-19,22-25,29,31-53,55-57H2,1H3,(H2,95,132)(H,100,123)(H,101,122)(H,105,125)(H,106,124)(H,107,140)(H,108,137)(H,109,138)(H,110,139)(H,111,133)(H,112,136)(H,113,134)(H,114,135)(H,115,141)(H,126,127)(H,128,129)(H,130,131)(H4,96,97,102)(H4,98,99,103)(H,116,117,118,119)/t60-,63+,64+,65+,66+,67+,68+,69+,70+,71-,72+,73+/m1/s1 | UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 270 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbumin |
J Med Chem 55: 1969-77 (2012)
Article DOI: 10.1021/jm201489a
BindingDB Entry DOI: 10.7270/Q2DN464P |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 3
(Homo sapiens (Human)) | BDBM50389781
(CHEMBL2070254)Show SMILES CCCC[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCc1nnn[nH]1)C(=O)N[C@H]1CCC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O)C(N)=O |r,wU:37.42,28.33,83.83,133.142,122.125,111.114,93.146,wD:17.24,8.13,4.4,97.98,135.139,(40.6,-30.05,;41.4,-28.73,;40.65,-27.38,;41.45,-26.06,;40.69,-24.71,;39.16,-24.71,;38.41,-23.32,;39.2,-22.02,;36.87,-23.32,;36.08,-24.63,;36.82,-25.98,;36.03,-27.3,;34.49,-27.3,;36.78,-28.65,;36.12,-21.97,;36.91,-20.65,;38.45,-20.65,;36.16,-19.31,;34.62,-19.31,;33.88,-17.93,;32.34,-17.93,;31.59,-16.53,;30.05,-16.53,;29.3,-15.19,;29.26,-17.86,;36.95,-17.98,;36.2,-16.63,;34.67,-16.63,;36.99,-15.32,;38.54,-15.32,;39.33,-14.05,;40.87,-14.05,;41.61,-15.39,;41.66,-12.73,;36.25,-13.97,;37.04,-12.65,;38.58,-12.65,;36.29,-11.31,;37.08,-9.98,;38.62,-9.98,;39.41,-8.69,;40.95,-8.69,;38.07,-7.91,;34.75,-11.31,;34,-9.93,;34.79,-8.61,;32.46,-9.93,;31.71,-8.56,;32.51,-7.24,;34.05,-7.24,;31.76,-5.89,;32.56,-4.57,;34.1,-4.57,;34.84,-5.95,;36.38,-5.95,;37.13,-7.32,;38.67,-7.32,;39.46,-6.06,;41,-6.06,;41.75,-7.4,;41.79,-4.74,;43.33,-4.74,;44.08,-6.11,;45.62,-6.11,;46.37,-7.48,;47.91,-7.48,;48.65,-8.86,;50.19,-8.86,;50.94,-10.23,;52.48,-10.23,;53.27,-8.94,;52.53,-7.59,;53.32,-6.27,;52.57,-4.93,;53.37,-3.61,;52.62,-2.26,;51.08,-2.07,;50.8,-.57,;52.13,.19,;53.27,-.87,;41.49,-23.39,;40.74,-22.05,;43.03,-23.39,;43.82,-22.1,;43.24,-20.67,;44.27,-19.04,;44.27,-10.73,;43.18,-9.65,;66.22,-10.73,;66.22,-15.88,;64.85,-16.63,;64.85,-18.17,;63.49,-18.92,;63.49,-20.46,;62.14,-21.21,;60.82,-20.42,;60.82,-18.89,;59.48,-21.17,;59.48,-22.72,;60.77,-23.5,;62.19,-22.9,;63.21,-24.05,;62.42,-25.37,;62.87,-26.85,;61.82,-27.98,;60.32,-27.64,;59.87,-26.17,;60.91,-25.04,;58.15,-20.39,;56.81,-21.14,;56.81,-22.67,;55.48,-20.35,;55.48,-18.8,;56.85,-18.05,;56.85,-16.52,;58.24,-15.76,;58.24,-14.23,;56.92,-13.44,;59.59,-13.47,;54.14,-21.09,;52.82,-20.31,;52.82,-18.77,;51.48,-21.06,;51.48,-22.6,;52.77,-23.39,;54.12,-22.64,;55.44,-23.43,;55.44,-24.96,;54.08,-25.71,;52.77,-24.92,;50.16,-20.27,;48.81,-21.02,;48.81,-22.55,;47.49,-20.23,;47.59,-18.67,;45.95,-18.32,;45.27,-16.79,;45.1,-19.76,;46.21,-21.03,;45.35,-22.31,;46.01,-23.7,;64.81,-21.25,;66.16,-20.5,;64.81,-22.79,)| Show InChI InChI=1S/C94H146N26O24/c1-2-3-29-64(84(134)113-70-36-40-76(123)100-44-23-22-31-63(82(95)132)107-90(140)72(52-59-54-104-62-30-21-20-28-61(59)62)114-85(135)66(33-25-46-103-94(98)99)110-89(139)71(51-58-26-16-15-17-27-58)115-91(141)73-53-60(121)56-120(73)92(70)142)108-87(137)68(38-42-80(128)129)111-83(133)65(32-24-45-102-93(96)97)109-88(138)69(39-43-81(130)131)112-86(136)67(37-41-79(126)127)106-77(124)55-105-78(125)57-144-50-49-143-48-47-101-75(122)35-19-14-12-10-8-6-4-5-7-9-11-13-18-34-74-116-118-119-117-74/h15-17,20-21,26-28,30,54,60,63-73,104,121H,2-14,18-19,22-25,29,31-53,55-57H2,1H3,(H2,95,132)(H,100,123)(H,101,122)(H,105,125)(H,106,124)(H,107,140)(H,108,137)(H,109,138)(H,110,139)(H,111,133)(H,112,136)(H,113,134)(H,114,135)(H,115,141)(H,126,127)(H,128,129)(H,130,131)(H4,96,97,102)(H4,98,99,103)(H,116,117,118,119)/t60-,63+,64+,65+,66+,67+,68+,69+,70+,71-,72+,73+/m1/s1 | UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbumin |
J Med Chem 55: 1969-77 (2012)
Article DOI: 10.1021/jm201489a
BindingDB Entry DOI: 10.7270/Q2DN464P |
More data for this
Ligand-Target Pair | |
Melanocyte-stimulating hormone receptor
(Homo sapiens (Human)) | BDBM50389781
(CHEMBL2070254)Show SMILES CCCC[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCc1nnn[nH]1)C(=O)N[C@H]1CCC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O)C(N)=O |r,wU:37.42,28.33,83.83,133.142,122.125,111.114,93.146,wD:17.24,8.13,4.4,97.98,135.139,(40.6,-30.05,;41.4,-28.73,;40.65,-27.38,;41.45,-26.06,;40.69,-24.71,;39.16,-24.71,;38.41,-23.32,;39.2,-22.02,;36.87,-23.32,;36.08,-24.63,;36.82,-25.98,;36.03,-27.3,;34.49,-27.3,;36.78,-28.65,;36.12,-21.97,;36.91,-20.65,;38.45,-20.65,;36.16,-19.31,;34.62,-19.31,;33.88,-17.93,;32.34,-17.93,;31.59,-16.53,;30.05,-16.53,;29.3,-15.19,;29.26,-17.86,;36.95,-17.98,;36.2,-16.63,;34.67,-16.63,;36.99,-15.32,;38.54,-15.32,;39.33,-14.05,;40.87,-14.05,;41.61,-15.39,;41.66,-12.73,;36.25,-13.97,;37.04,-12.65,;38.58,-12.65,;36.29,-11.31,;37.08,-9.98,;38.62,-9.98,;39.41,-8.69,;40.95,-8.69,;38.07,-7.91,;34.75,-11.31,;34,-9.93,;34.79,-8.61,;32.46,-9.93,;31.71,-8.56,;32.51,-7.24,;34.05,-7.24,;31.76,-5.89,;32.56,-4.57,;34.1,-4.57,;34.84,-5.95,;36.38,-5.95,;37.13,-7.32,;38.67,-7.32,;39.46,-6.06,;41,-6.06,;41.75,-7.4,;41.79,-4.74,;43.33,-4.74,;44.08,-6.11,;45.62,-6.11,;46.37,-7.48,;47.91,-7.48,;48.65,-8.86,;50.19,-8.86,;50.94,-10.23,;52.48,-10.23,;53.27,-8.94,;52.53,-7.59,;53.32,-6.27,;52.57,-4.93,;53.37,-3.61,;52.62,-2.26,;51.08,-2.07,;50.8,-.57,;52.13,.19,;53.27,-.87,;41.49,-23.39,;40.74,-22.05,;43.03,-23.39,;43.82,-22.1,;43.24,-20.67,;44.27,-19.04,;44.27,-10.73,;43.18,-9.65,;66.22,-10.73,;66.22,-15.88,;64.85,-16.63,;64.85,-18.17,;63.49,-18.92,;63.49,-20.46,;62.14,-21.21,;60.82,-20.42,;60.82,-18.89,;59.48,-21.17,;59.48,-22.72,;60.77,-23.5,;62.19,-22.9,;63.21,-24.05,;62.42,-25.37,;62.87,-26.85,;61.82,-27.98,;60.32,-27.64,;59.87,-26.17,;60.91,-25.04,;58.15,-20.39,;56.81,-21.14,;56.81,-22.67,;55.48,-20.35,;55.48,-18.8,;56.85,-18.05,;56.85,-16.52,;58.24,-15.76,;58.24,-14.23,;56.92,-13.44,;59.59,-13.47,;54.14,-21.09,;52.82,-20.31,;52.82,-18.77,;51.48,-21.06,;51.48,-22.6,;52.77,-23.39,;54.12,-22.64,;55.44,-23.43,;55.44,-24.96,;54.08,-25.71,;52.77,-24.92,;50.16,-20.27,;48.81,-21.02,;48.81,-22.55,;47.49,-20.23,;47.59,-18.67,;45.95,-18.32,;45.27,-16.79,;45.1,-19.76,;46.21,-21.03,;45.35,-22.31,;46.01,-23.7,;64.81,-21.25,;66.16,-20.5,;64.81,-22.79,)| Show InChI InChI=1S/C94H146N26O24/c1-2-3-29-64(84(134)113-70-36-40-76(123)100-44-23-22-31-63(82(95)132)107-90(140)72(52-59-54-104-62-30-21-20-28-61(59)62)114-85(135)66(33-25-46-103-94(98)99)110-89(139)71(51-58-26-16-15-17-27-58)115-91(141)73-53-60(121)56-120(73)92(70)142)108-87(137)68(38-42-80(128)129)111-83(133)65(32-24-45-102-93(96)97)109-88(138)69(39-43-81(130)131)112-86(136)67(37-41-79(126)127)106-77(124)55-105-78(125)57-144-50-49-143-48-47-101-75(122)35-19-14-12-10-8-6-4-5-7-9-11-13-18-34-74-116-118-119-117-74/h15-17,20-21,26-28,30,54,60,63-73,104,121H,2-14,18-19,22-25,29,31-53,55-57H2,1H3,(H2,95,132)(H,100,123)(H,101,122)(H,105,125)(H,106,124)(H,107,140)(H,108,137)(H,109,138)(H,110,139)(H,111,133)(H,112,136)(H,113,134)(H,114,135)(H,115,141)(H,126,127)(H,128,129)(H,130,131)(H4,96,97,102)(H4,98,99,103)(H,116,117,118,119)/t60-,63+,64+,65+,66+,67+,68+,69+,70+,71-,72+,73+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Displacement of [125I]-NAD-alpha-MSH from human recombinant MC1 receptor expressed in BHK570 cells after 90 mins in presence of ovalbumin |
J Med Chem 55: 1969-77 (2012)
Article DOI: 10.1021/jm201489a
BindingDB Entry DOI: 10.7270/Q2DN464P |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50389781
(CHEMBL2070254)Show SMILES CCCC[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCc1nnn[nH]1)C(=O)N[C@H]1CCC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O)C(N)=O |r,wU:37.42,28.33,83.83,133.142,122.125,111.114,93.146,wD:17.24,8.13,4.4,97.98,135.139,(40.6,-30.05,;41.4,-28.73,;40.65,-27.38,;41.45,-26.06,;40.69,-24.71,;39.16,-24.71,;38.41,-23.32,;39.2,-22.02,;36.87,-23.32,;36.08,-24.63,;36.82,-25.98,;36.03,-27.3,;34.49,-27.3,;36.78,-28.65,;36.12,-21.97,;36.91,-20.65,;38.45,-20.65,;36.16,-19.31,;34.62,-19.31,;33.88,-17.93,;32.34,-17.93,;31.59,-16.53,;30.05,-16.53,;29.3,-15.19,;29.26,-17.86,;36.95,-17.98,;36.2,-16.63,;34.67,-16.63,;36.99,-15.32,;38.54,-15.32,;39.33,-14.05,;40.87,-14.05,;41.61,-15.39,;41.66,-12.73,;36.25,-13.97,;37.04,-12.65,;38.58,-12.65,;36.29,-11.31,;37.08,-9.98,;38.62,-9.98,;39.41,-8.69,;40.95,-8.69,;38.07,-7.91,;34.75,-11.31,;34,-9.93,;34.79,-8.61,;32.46,-9.93,;31.71,-8.56,;32.51,-7.24,;34.05,-7.24,;31.76,-5.89,;32.56,-4.57,;34.1,-4.57,;34.84,-5.95,;36.38,-5.95,;37.13,-7.32,;38.67,-7.32,;39.46,-6.06,;41,-6.06,;41.75,-7.4,;41.79,-4.74,;43.33,-4.74,;44.08,-6.11,;45.62,-6.11,;46.37,-7.48,;47.91,-7.48,;48.65,-8.86,;50.19,-8.86,;50.94,-10.23,;52.48,-10.23,;53.27,-8.94,;52.53,-7.59,;53.32,-6.27,;52.57,-4.93,;53.37,-3.61,;52.62,-2.26,;51.08,-2.07,;50.8,-.57,;52.13,.19,;53.27,-.87,;41.49,-23.39,;40.74,-22.05,;43.03,-23.39,;43.82,-22.1,;43.24,-20.67,;44.27,-19.04,;44.27,-10.73,;43.18,-9.65,;66.22,-10.73,;66.22,-15.88,;64.85,-16.63,;64.85,-18.17,;63.49,-18.92,;63.49,-20.46,;62.14,-21.21,;60.82,-20.42,;60.82,-18.89,;59.48,-21.17,;59.48,-22.72,;60.77,-23.5,;62.19,-22.9,;63.21,-24.05,;62.42,-25.37,;62.87,-26.85,;61.82,-27.98,;60.32,-27.64,;59.87,-26.17,;60.91,-25.04,;58.15,-20.39,;56.81,-21.14,;56.81,-22.67,;55.48,-20.35,;55.48,-18.8,;56.85,-18.05,;56.85,-16.52,;58.24,-15.76,;58.24,-14.23,;56.92,-13.44,;59.59,-13.47,;54.14,-21.09,;52.82,-20.31,;52.82,-18.77,;51.48,-21.06,;51.48,-22.6,;52.77,-23.39,;54.12,-22.64,;55.44,-23.43,;55.44,-24.96,;54.08,-25.71,;52.77,-24.92,;50.16,-20.27,;48.81,-21.02,;48.81,-22.55,;47.49,-20.23,;47.59,-18.67,;45.95,-18.32,;45.27,-16.79,;45.1,-19.76,;46.21,-21.03,;45.35,-22.31,;46.01,-23.7,;64.81,-21.25,;66.16,-20.5,;64.81,-22.79,)| Show InChI InChI=1S/C94H146N26O24/c1-2-3-29-64(84(134)113-70-36-40-76(123)100-44-23-22-31-63(82(95)132)107-90(140)72(52-59-54-104-62-30-21-20-28-61(59)62)114-85(135)66(33-25-46-103-94(98)99)110-89(139)71(51-58-26-16-15-17-27-58)115-91(141)73-53-60(121)56-120(73)92(70)142)108-87(137)68(38-42-80(128)129)111-83(133)65(32-24-45-102-93(96)97)109-88(138)69(39-43-81(130)131)112-86(136)67(37-41-79(126)127)106-77(124)55-105-78(125)57-144-50-49-143-48-47-101-75(122)35-19-14-12-10-8-6-4-5-7-9-11-13-18-34-74-116-118-119-117-74/h15-17,20-21,26-28,30,54,60,63-73,104,121H,2-14,18-19,22-25,29,31-53,55-57H2,1H3,(H2,95,132)(H,100,123)(H,101,122)(H,105,125)(H,106,124)(H,107,140)(H,108,137)(H,109,138)(H,110,139)(H,111,133)(H,112,136)(H,113,134)(H,114,135)(H,115,141)(H,126,127)(H,128,129)(H,130,131)(H4,96,97,102)(H4,98,99,103)(H,116,117,118,119)/t60-,63+,64+,65+,66+,67+,68+,69+,70+,71-,72+,73+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 270 | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Agonist activity at human recombinant MC4 receptor expressed in BHK570 cells assessed as induction of cMAP accumulation in presence of 0.1% human ser... |
J Med Chem 55: 1969-77 (2012)
Article DOI: 10.1021/jm201489a
BindingDB Entry DOI: 10.7270/Q2DN464P |
More data for this
Ligand-Target Pair | |
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