BindingDB PrimarySearch

BDBM50389928 CHEMBL2071063

SMILES: CCc1c([nH]c2ccc(Cl)cc12)C(=O)NCCc1ccc(cc1)N(C)C

InChI Key: InChIKey=WVXDJOGNHLCWST-UHFFFAOYSA-N

Data: 2 IC50 5 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50389928
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Cannabinoid receptor 1 (Homo sapiens (Human))	BDBM50389928 (CHEMBL2071063) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	787	n/a	n/a	n/a	n/a	n/a	n/a
Research Triangle Institute Curated by ChEMBL					Assay Description Antagonist activity at human CB1 receptor expressed in CHO-RD-HGA16 cells assessed as inhibition of CP55940-induced calcium mobilization incubated fo...				Bioorg Med Chem 23: 2195-203 (2015) Article DOI: 10.1016/j.bmc.2015.02.058 BindingDB Entry DOI: 10.7270/Q29888PG
Research Triangle Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Cannabinoid receptor 1 (Homo sapiens (Human))	BDBM50389928 (CHEMBL2071063) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	210	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Agonist activity at human CB1 receptor expressed in HEK cells assessed as inhibition of forskolin-induced cAMP accumulation				J Med Chem 58: 5979-88 (2015) Article DOI: 10.1021/acs.jmedchem.5b00579 BindingDB Entry DOI: 10.7270/Q2PG1TG7
University of Auckland Curated by ChEMBL					More data for this Ligand-Target Pair
Cannabinoid receptor 1 (Homo sapiens (Human))	BDBM50389928 (CHEMBL2071063) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	600	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Activity at hemagglutinin-tagged human CB1 receptor expressed in HEK293 cells assessed as effect on forskolin-induced cAMP accumulation after 15 mins...				J Med Chem 58: 5979-88 (2015) Article DOI: 10.1021/acs.jmedchem.5b00579 BindingDB Entry DOI: 10.7270/Q2PG1TG7
University of Auckland Curated by ChEMBL					More data for this Ligand-Target Pair
Cannabinoid receptor 2 (Homo sapiens (Human))	BDBM50389928 (CHEMBL2071063) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Sapienza Universit£ di Roma Curated by ChEMBL					Assay Description Allosteric modulation of human recombinant CB2 receptor expressed in HEK293 cells assessed as inhibition of [3H]CP55940 binding				J Med Chem 55: 5627-31 (2012) Article DOI: 10.1021/jm201485c BindingDB Entry DOI: 10.7270/Q27W6D8K
Sapienza Universit£ di Roma Curated by ChEMBL					More data for this Ligand-Target Pair
Cannabinoid receptor 1 (Homo sapiens (Human))	BDBM50389928 (CHEMBL2071063) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	430	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Activity at hemagglutinin-tagged human CB1 receptor expressed in HEK293 cells assessed as effect on forskolin-induced cAMP accumulation after 15 mins...				J Med Chem 58: 5979-88 (2015) Article DOI: 10.1021/acs.jmedchem.5b00579 BindingDB Entry DOI: 10.7270/Q2PG1TG7
University of Auckland Curated by ChEMBL					More data for this Ligand-Target Pair
Cannabinoid receptor 1 (Homo sapiens (Human))	BDBM50389928 (CHEMBL2071063) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	50	n/a	n/a	n/a	n/a
Sapienza Universit£ di Roma Curated by ChEMBL					Assay Description Allosteric modulation of human recombinant CB1 receptor expressed in HEK293 cells assessed as stimulation of [3H]CP55940 binding				J Med Chem 55: 5627-31 (2012) Article DOI: 10.1021/jm201485c BindingDB Entry DOI: 10.7270/Q27W6D8K
Sapienza Universit£ di Roma Curated by ChEMBL					More data for this Ligand-Target Pair
Cannabinoid receptor 1 (Homo sapiens (Human))	BDBM50389928 (CHEMBL2071063) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	3.43E+3	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Activity at hemagglutinin-tagged human CB1 receptor expressed in HEK293 cells assessed as effect on forskolin-induced cAMP accumulation after 15 mins...				J Med Chem 58: 5979-88 (2015) Article DOI: 10.1021/acs.jmedchem.5b00579 BindingDB Entry DOI: 10.7270/Q2PG1TG7
University of Auckland Curated by ChEMBL					More data for this Ligand-Target Pair