BDBM50389992 CHEMBL2071272

SMILES: NC(=O)Cn1cc(Nc2ncc(Cl)c(N[C@@H]3[C@@H]4C[C@@H](C=C4)[C@@H]3C(N)=O)n2)cn1

InChI Key: InChIKey=MENUIGPUGBMCMV-OBPYKSBLSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50389992   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50389992 (CHEMBL2071272) Show SMILES NC(=O)Cn1cc(Nc2ncc(Cl)c(N[C@@H]3[C@@H]4C[C@@H](C=C4)[C@@H]3C(N)=O)n2)cn1 |r,c:19| Show InChI InChI=1S/C17H19ClN8O2/c18-11-5-21-17(23-10-4-22-26(6-10)7-12(19)27)25-16(11)24-14-9-2-1-8(3-9)13(14)15(20)28/h1-2,4-6,8-9,13-14H,3,7H2,(H2,19,27)(H2,20,28)(H2,21,23,24,25)/t8-,9+,13+,14-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	167	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of human KDR autophosphorylation expressed in mouse NIH/3T3 cells				Bioorg Med Chem Lett 22: 4750-5 (2012) Article DOI: 10.1016/j.bmcl.2012.05.067 BindingDB Entry DOI: 10.7270/Q20C4WTF
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50389992 (CHEMBL2071272) Show SMILES NC(=O)Cn1cc(Nc2ncc(Cl)c(N[C@@H]3[C@@H]4C[C@@H](C=C4)[C@@H]3C(N)=O)n2)cn1 |r,c:19| Show InChI InChI=1S/C17H19ClN8O2/c18-11-5-21-17(23-10-4-22-26(6-10)7-12(19)27)25-16(11)24-14-9-2-1-8(3-9)13(14)15(20)28/h1-2,4-6,8-9,13-14H,3,7H2,(H2,19,27)(H2,20,28)(H2,21,23,24,25)/t8-,9+,13+,14-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of KDR by HTRF analysis in presence of 1 mM ATP				Bioorg Med Chem Lett 22: 4750-5 (2012) Article DOI: 10.1016/j.bmcl.2012.05.067 BindingDB Entry DOI: 10.7270/Q20C4WTF
					More data for this Ligand-Target Pair
Aurora kinase B (Homo sapiens (Human))	BDBM50389992 (CHEMBL2071272) Show SMILES NC(=O)Cn1cc(Nc2ncc(Cl)c(N[C@@H]3[C@@H]4C[C@@H](C=C4)[C@@H]3C(N)=O)n2)cn1 |r,c:19| Show InChI InChI=1S/C17H19ClN8O2/c18-11-5-21-17(23-10-4-22-26(6-10)7-12(19)27)25-16(11)24-14-9-2-1-8(3-9)13(14)15(20)28/h1-2,4-6,8-9,13-14H,3,7H2,(H2,19,27)(H2,20,28)(H2,21,23,24,25)/t8-,9+,13+,14-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of Aurora B kinase by HTRF analysis in presence of 1 mM ATP				Bioorg Med Chem Lett 22: 4750-5 (2012) Article DOI: 10.1016/j.bmcl.2012.05.067 BindingDB Entry DOI: 10.7270/Q20C4WTF
					More data for this Ligand-Target Pair