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BDBM50390793 CHEMBL2070617

SMILES: COC(=O)Nc1ncc(s1)-c1cc(nc(n1)-c1cnccn1)-c1c(C)cc(OC)cc1C

InChI Key: InChIKey=MTHYJGOTWRWQBV-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50390793   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
LIM domain kinase 1


(Homo sapiens (Human))
BDBM50390793
PNG
(CHEMBL2070617)
Show SMILES COC(=O)Nc1ncc(s1)-c1cc(nc(n1)-c1cnccn1)-c1c(C)cc(OC)cc1C
Show InChI InChI=1S/C22H20N6O3S/c1-12-7-14(30-3)8-13(2)19(12)16-9-15(18-11-25-21(32-18)28-22(29)31-4)26-20(27-16)17-10-23-5-6-24-17/h5-11H,1-4H3,(H,25,28,29)
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PC cid
PC sid
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Article
PubMed
n/an/a 284n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of LIMK1


Bioorg Med Chem Lett 22: 5995-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.002
BindingDB Entry DOI: 10.7270/Q2K075CJ
More data for this
Ligand-Target Pair
Dual specificity testis-specific protein kinase 2


(Homo sapiens (Human))
BDBM50390793
PNG
(CHEMBL2070617)
Show SMILES COC(=O)Nc1ncc(s1)-c1cc(nc(n1)-c1cnccn1)-c1c(C)cc(OC)cc1C
Show InChI InChI=1S/C22H20N6O3S/c1-12-7-14(30-3)8-13(2)19(12)16-9-15(18-11-25-21(32-18)28-22(29)31-4)26-20(27-16)17-10-23-5-6-24-17/h5-11H,1-4H3,(H,25,28,29)
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CHEMBL
PC cid
PC sid
UniChem
Article
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n/an/a 2.74E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of TESK2


Bioorg Med Chem Lett 22: 5995-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.002
BindingDB Entry DOI: 10.7270/Q2K075CJ
More data for this
Ligand-Target Pair
Dual specificity testis-specific protein kinase 1


(Homo sapiens (Human))
BDBM50390793
PNG
(CHEMBL2070617)
Show SMILES COC(=O)Nc1ncc(s1)-c1cc(nc(n1)-c1cnccn1)-c1c(C)cc(OC)cc1C
Show InChI InChI=1S/C22H20N6O3S/c1-12-7-14(30-3)8-13(2)19(12)16-9-15(18-11-25-21(32-18)28-22(29)31-4)26-20(27-16)17-10-23-5-6-24-17/h5-11H,1-4H3,(H,25,28,29)
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n/an/a 1.19E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of TESK1


Bioorg Med Chem Lett 22: 5995-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.002
BindingDB Entry DOI: 10.7270/Q2K075CJ
More data for this
Ligand-Target Pair
LIM domain kinase 2


(Homo sapiens (Human))
BDBM50390793
PNG
(CHEMBL2070617)
Show SMILES COC(=O)Nc1ncc(s1)-c1cc(nc(n1)-c1cnccn1)-c1c(C)cc(OC)cc1C
Show InChI InChI=1S/C22H20N6O3S/c1-12-7-14(30-3)8-13(2)19(12)16-9-15(18-11-25-21(32-18)28-22(29)31-4)26-20(27-16)17-10-23-5-6-24-17/h5-11H,1-4H3,(H,25,28,29)
PDB
MMDB

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KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 202n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of LIMK2


Bioorg Med Chem Lett 22: 5995-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.002
BindingDB Entry DOI: 10.7270/Q2K075CJ
More data for this
Ligand-Target Pair