BDBM50390819 CHEMBL2070656

SMILES: COc1cc(cc2c1nnc1c(C)nc(-c3ccncc3C)n21)N1CCOCC1

InChI Key: InChIKey=LZYLOUZRUVTOJN-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50390819   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50390819 (CHEMBL2070656) Show SMILES COc1cc(cc2c1nnc1c(C)nc(-c3ccncc3C)n21)N1CCOCC1 Show InChI InChI=1S/C21H22N6O2/c1-13-12-22-5-4-16(13)21-23-14(2)20-25-24-19-17(27(20)21)10-15(11-18(19)28-3)26-6-8-29-9-7-26/h4-5,10-12H,6-9H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.99	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE10A-catalyzed cAMP hydrolysis				Bioorg Med Chem Lett 22: 5876-84 (2012) Article DOI: 10.1016/j.bmcl.2012.07.076 BindingDB Entry DOI: 10.7270/Q2FB5413
					More data for this Ligand-Target Pair