BDBM50390890 CHEMBL2070983

SMILES: COc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2C(=O)c2ccccc2OC)n1

InChI Key: InChIKey=BLXBGGFWFCFTDM-HXUWFJFHSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50390890   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
KCNQ (Kv7) potassium channel (Homo sapiens (Human))	BDBM50390890 (CHEMBL2070983) Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2C(=O)c2ccccc2OC)n1 |r| Show InChI InChI=1S/C24H25N3O4S/c1-30-17-12-10-16(11-13-17)19-15-32-24(25-19)26-22(28)20-8-5-6-14-27(20)23(29)18-7-3-4-9-21(18)31-2/h3-4,7,9-13,15,20H,5-6,8,14H2,1-2H3,(H,25,26,28)/t20-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay				Bioorg Med Chem Lett 22: 5936-41 (2012) Article DOI: 10.1016/j.bmcl.2012.07.060 BindingDB Entry DOI: 10.7270/Q25T3MKN
					More data for this Ligand-Target Pair