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BDBM50390896 CHEMBL2070989

SMILES: COc1ccc(cc1)-c1csc(NC(=O)C2CNCCN2S(=O)(=O)c2ccc(C)cc2)n1

InChI Key: InChIKey=KOIHPOHJCCHBHO-UHFFFAOYSA-N

Data: 1 EC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50390896   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390896
PNG
(CHEMBL2070989)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)C2CNCCN2S(=O)(=O)c2ccc(C)cc2)n1
Show InChI InChI=1S/C22H24N4O4S2/c1-15-3-9-18(10-4-15)32(28,29)26-12-11-23-13-20(26)21(27)25-22-24-19(14-31-22)16-5-7-17(30-2)8-6-16/h3-10,14,20,23H,11-13H2,1-2H3,(H,24,25,27)
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Article
PubMed
n/an/an/an/a>3.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
BindingDB Entry DOI: 10.7270/Q25T3MKN
More data for this
Ligand-Target Pair