BDBM50390906 CHEMBL2071001

SMILES: Cc1ccc(cc1)S(=O)(=O)N1CCCC[C@@H]1C(=O)Nc1nc(cs1)-c1ccc(Cl)cc1

InChI Key: InChIKey=UEILPNWTGNXVFQ-HXUWFJFHSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50390906   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
KCNQ (Kv7) potassium channel (Homo sapiens (Human))	BDBM50390906 (CHEMBL2071001) Show SMILES Cc1ccc(cc1)S(=O)(=O)N1CCCC[C@@H]1C(=O)Nc1nc(cs1)-c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C22H22ClN3O3S2/c1-15-5-11-18(12-6-15)31(28,29)26-13-3-2-4-20(26)21(27)25-22-24-19(14-30-22)16-7-9-17(23)10-8-16/h5-12,14,20H,2-4,13H2,1H3,(H,24,25,27)/t20-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay				Bioorg Med Chem Lett 22: 5936-41 (2012) Article DOI: 10.1016/j.bmcl.2012.07.060 BindingDB Entry DOI: 10.7270/Q25T3MKN
					More data for this Ligand-Target Pair