BDBM50391505 CHEMBL2147304

SMILES: COc1ncc(cn1)-c1cccc(OC(F)F)c1CCNC(=O)c1ccc(OCCC(F)(F)F)nc1

InChI Key: InChIKey=MYWFFPRATNYWJR-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50391505   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human))	BDBM50391505 (CHEMBL2147304) Show SMILES COc1ncc(cn1)-c1cccc(OC(F)F)c1CCNC(=O)c1ccc(OCCC(F)(F)F)nc1 Show InChI InChI=1S/C23H21F5N4O4/c1-34-22-31-12-15(13-32-22)16-3-2-4-18(36-21(24)25)17(16)7-9-29-20(33)14-5-6-19(30-11-14)35-10-8-23(26,27)28/h2-6,11-13,21H,7-10H2,1H3,(H,29,33)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.94E+3	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of human Nav1.5				Bioorg Med Chem Lett 22: 6108-15 (2012) Article DOI: 10.1016/j.bmcl.2012.08.031 BindingDB Entry DOI: 10.7270/Q2B8596S
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM50391505 (CHEMBL2147304) Show SMILES COc1ncc(cn1)-c1cccc(OC(F)F)c1CCNC(=O)c1ccc(OCCC(F)(F)F)nc1 Show InChI InChI=1S/C23H21F5N4O4/c1-34-22-31-12-15(13-32-22)16-3-2-4-18(36-21(24)25)17(16)7-9-29-20(33)14-5-6-19(30-11-14)35-10-8-23(26,27)28/h2-6,11-13,21H,7-10H2,1H3,(H,29,33)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	<1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of human Nav1.7 expressed in HEK293 cells by whole cell voltage-clamp electrophysiology assay				Bioorg Med Chem Lett 22: 6108-15 (2012) Article DOI: 10.1016/j.bmcl.2012.08.031 BindingDB Entry DOI: 10.7270/Q2B8596S
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50391505 (CHEMBL2147304) Show SMILES COc1ncc(cn1)-c1cccc(OC(F)F)c1CCNC(=O)c1ccc(OCCC(F)(F)F)nc1 Show InChI InChI=1S/C23H21F5N4O4/c1-34-22-31-12-15(13-32-22)16-3-2-4-18(36-21(24)25)17(16)7-9-29-20(33)14-5-6-19(30-11-14)35-10-8-23(26,27)28/h2-6,11-13,21H,7-10H2,1H3,(H,29,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.98E+3	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of human ERG channel by whole cell voltage-clamp electrophysiology assay				Bioorg Med Chem Lett 22: 6108-15 (2012) Article DOI: 10.1016/j.bmcl.2012.08.031 BindingDB Entry DOI: 10.7270/Q2B8596S
					More data for this Ligand-Target Pair