BDBM50391861 CHEMBL2147284

SMILES: CCc1ccc(cc1)-c1ccccc1C(=O)Nc1ccc2cc(ccc2n1)C(=O)N[C@H](C(=O)N(C)Cc1ccc(F)cc1)c1ccccc1

InChI Key: InChIKey=OLCIBVKTMMFOTI-LHEWISCISA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50391861   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Microsomal triglyceride transfer protein (Homo sapiens (Human))	BDBM50391861 (CHEMBL2147284) Show SMILES CCc1ccc(cc1)-c1ccccc1C(=O)Nc1ccc2cc(ccc2n1)C(=O)N[C@H](C(=O)N(C)Cc1ccc(F)cc1)c1ccccc1 |r| Show InChI InChI=1S/C41H35FN4O3/c1-3-27-13-17-29(18-14-27)34-11-7-8-12-35(34)40(48)44-37-24-20-31-25-32(19-23-36(31)43-37)39(47)45-38(30-9-5-4-6-10-30)41(49)46(2)26-28-15-21-33(42)22-16-28/h4-25,38H,3,26H2,1-2H3,(H,45,47)(H,43,44,48)/t38-/m0/s1	PDB Reactome pathway KEGG DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.550	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of MTP in human HepG2 cells assessed as inhibition of apoB secretion after 40 hrs by ELISA				Bioorg Med Chem Lett 21: 4150-4 (2011) Article DOI: 10.1016/j.bmcl.2011.05.099 BindingDB Entry DOI: 10.7270/Q2B27WCR
					More data for this Ligand-Target Pair