BDBM50391879 CHEMBL2147288
SMILES: COc1ccc(cc1)-c1ccccc1C(=O)Nc1ccc2cc(ccc2n1)C(=O)N[C@H](C(=O)N(C)Cc1ccc(F)cc1)c1ccccc1
InChI Key: InChIKey=AEKLUJNEHYJEKW-QNGWXLTQSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Microsomal triglyceride transfer protein (Homo sapiens (Human)) | BDBM50391879 (CHEMBL2147288) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Inhibition of MTP in human HepG2 cells assessed as inhibition of apoB secretion after 40 hrs by ELISA | Bioorg Med Chem Lett 21: 4150-4 (2011) Article DOI: 10.1016/j.bmcl.2011.05.099 BindingDB Entry DOI: 10.7270/Q2B27WCR | |||||||||||
More data for this Ligand-Target Pair |