BDBM50392659 CHEMBL2153708
SMILES: Nc1nc(N)c2NC(CNc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)CCc2n1
InChI Key: InChIKey=NJZPEYYRVZHUEO-PYMCNQPYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Methionine synthase (Homo sapiens (Human)) | BDBM50392659 (CHEMBL2153708) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 8.79E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Peking University Curated by ChEMBL | Assay Description Inhibition of methionine synthase in human HL60 cells using L-homocysteine as substrate incubated for 3 hrs prior to substrate addition measured afte... | Eur J Med Chem 58: 228-36 (2012) Article DOI: 10.1016/j.ejmech.2012.09.027 BindingDB Entry DOI: 10.7270/Q2RX9D5C | |||||||||||
More data for this Ligand-Target Pair |