BDBM50393282 CHEMBL2139663

SMILES: Cc1ccc(CNc2nc(nnc2-c2ccccc2)-c2ccccn2)cc1

InChI Key: InChIKey=XXSFXQLMBCXBAH-UHFFFAOYSA-N

Data: 3 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50393282   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Hypoxia-inducible factor 1-alpha (Homo sapiens (Human))	BDBM50393282 (CHEMBL2139663) Show SMILES Cc1ccc(CNc2nc(nnc2-c2ccccc2)-c2ccccn2)cc1 Show InChI InChI=1S/C22H19N5/c1-16-10-12-17(13-11-16)15-24-22-20(18-7-3-2-4-8-18)26-27-21(25-22)19-9-5-6-14-23-19/h2-14H,15H2,1H3,(H,24,25,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	4.58E+3	n/a	n/a	n/a	n/a
The Broad Institute Probe Development Center Curated by ChEMBL					Assay Description Activation of human HIF1alpha expressed in DFX-induced human U2OS cells incubated for 30 mins prior to DFX-induction measured after overnight incubat...				Bioorg Med Chem Lett 22: 76-81 (2011) Article DOI: 10.1016/j.bmcl.2011.11.077 BindingDB Entry DOI: 10.7270/Q2XD12SN
					More data for this Ligand-Target Pair
Hypoxia-inducible factor 1-alpha (Homo sapiens (Human))	BDBM50393282 (CHEMBL2139663) Show SMILES Cc1ccc(CNc2nc(nnc2-c2ccccc2)-c2ccccn2)cc1 Show InChI InChI=1S/C22H19N5/c1-16-10-12-17(13-11-16)15-24-22-20(18-7-3-2-4-8-18)26-27-21(25-22)19-9-5-6-14-23-19/h2-14H,15H2,1H3,(H,24,25,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.60E+3	n/a	n/a	n/a	n/a
The Broad Institute Probe Development Center Curated by ChEMBL					Assay Description Activation of human HIF1alpha expressed in human U2OS cells assessed as increase in VEGF expression by RT-PCR analysis				Bioorg Med Chem Lett 22: 76-81 (2011) Article DOI: 10.1016/j.bmcl.2011.11.077 BindingDB Entry DOI: 10.7270/Q2XD12SN
					More data for this Ligand-Target Pair
Hypoxia-inducible factor 1-alpha (Homo sapiens (Human))	BDBM50393282 (CHEMBL2139663) Show SMILES Cc1ccc(CNc2nc(nnc2-c2ccccc2)-c2ccccn2)cc1 Show InChI InChI=1S/C22H19N5/c1-16-10-12-17(13-11-16)15-24-22-20(18-7-3-2-4-8-18)26-27-21(25-22)19-9-5-6-14-23-19/h2-14H,15H2,1H3,(H,24,25,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.19E+3	n/a	n/a	n/a	n/a
The Broad Institute Probe Development Center Curated by ChEMBL					Assay Description Activation of GFP-tagged HIF1alpha expressed in human U2OS cells assessed as HIF1alpha nuclear translocation by high content imaging assay				Bioorg Med Chem Lett 22: 76-81 (2011) Article DOI: 10.1016/j.bmcl.2011.11.077 BindingDB Entry DOI: 10.7270/Q2XD12SN
					More data for this Ligand-Target Pair