BDBM50393284 CHEMBL2132069

SMILES: C[C@@H](Nc1nc(nnc1-c1ccccc1)-c1ccccn1)C1CCCCC1

InChI Key: InChIKey=SWSOEWNFYYVHKJ-MRXNPFEDSA-N

Data: 3 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50393284   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Hypoxia-inducible factor 1-alpha (Homo sapiens (Human))	BDBM50393284 (CHEMBL2132069) Show SMILES C[C@@H](Nc1nc(nnc1-c1ccccc1)-c1ccccn1)C1CCCCC1 Show InChI InChI=1S/C22H25N5/c1-16(17-10-4-2-5-11-17)24-22-20(18-12-6-3-7-13-18)26-27-21(25-22)19-14-8-9-15-23-19/h3,6-9,12-17H,2,4-5,10-11H2,1H3,(H,24,25,27)/t16-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	6.73E+3	n/a	n/a	n/a	n/a
The Broad Institute Probe Development Center Curated by ChEMBL					Assay Description Activation of human HIF1alpha expressed in DFX-induced human U2OS cells incubated for 30 mins prior to DFX-induction measured after overnight incubat...				Bioorg Med Chem Lett 22: 76-81 (2011) Article DOI: 10.1016/j.bmcl.2011.11.077 BindingDB Entry DOI: 10.7270/Q2XD12SN
					More data for this Ligand-Target Pair
Hypoxia-inducible factor 1-alpha (Homo sapiens (Human))	BDBM50393284 (CHEMBL2132069) Show SMILES C[C@@H](Nc1nc(nnc1-c1ccccc1)-c1ccccn1)C1CCCCC1 Show InChI InChI=1S/C22H25N5/c1-16(17-10-4-2-5-11-17)24-22-20(18-12-6-3-7-13-18)26-27-21(25-22)19-14-8-9-15-23-19/h3,6-9,12-17H,2,4-5,10-11H2,1H3,(H,24,25,27)/t16-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.88E+3	n/a	n/a	n/a	n/a
The Broad Institute Probe Development Center Curated by ChEMBL					Assay Description Activation of human HIF1alpha expressed in human U2OS cells assessed as increase in VEGF expression by RT-PCR analysis				Bioorg Med Chem Lett 22: 76-81 (2011) Article DOI: 10.1016/j.bmcl.2011.11.077 BindingDB Entry DOI: 10.7270/Q2XD12SN
					More data for this Ligand-Target Pair
Hypoxia-inducible factor 1-alpha (Homo sapiens (Human))	BDBM50393284 (CHEMBL2132069) Show SMILES C[C@@H](Nc1nc(nnc1-c1ccccc1)-c1ccccn1)C1CCCCC1 Show InChI InChI=1S/C22H25N5/c1-16(17-10-4-2-5-11-17)24-22-20(18-12-6-3-7-13-18)26-27-21(25-22)19-14-8-9-15-23-19/h3,6-9,12-17H,2,4-5,10-11H2,1H3,(H,24,25,27)/t16-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a
The Broad Institute Probe Development Center Curated by ChEMBL					Assay Description Activation of GFP-tagged HIF1alpha expressed in human U2OS cells assessed as HIF1alpha nuclear translocation by high content imaging assay				Bioorg Med Chem Lett 22: 76-81 (2011) Article DOI: 10.1016/j.bmcl.2011.11.077 BindingDB Entry DOI: 10.7270/Q2XD12SN
					More data for this Ligand-Target Pair