BDBM50393295 CHEMBL2135309

SMILES: C(Nc1nc(nnc1-c1ccccc1)-c1ccccn1)c1cccc(c1)-c1ccccc1

InChI Key: InChIKey=MWRDNBONCUGSBY-UHFFFAOYSA-N

Data: 3 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50393295   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Hypoxia-inducible factor 1-alpha (Homo sapiens (Human))	BDBM50393295 (CHEMBL2135309) Show SMILES C(Nc1nc(nnc1-c1ccccc1)-c1ccccn1)c1cccc(c1)-c1ccccc1 Show InChI InChI=1S/C27H21N5/c1-3-11-21(12-4-1)23-15-9-10-20(18-23)19-29-27-25(22-13-5-2-6-14-22)31-32-26(30-27)24-16-7-8-17-28-24/h1-18H,19H2,(H,29,30,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.49E+3	n/a	n/a	n/a	n/a
The Broad Institute Probe Development Center Curated by ChEMBL					Assay Description Activation of human HIF1alpha expressed in DFX-induced human U2OS cells incubated for 30 mins prior to DFX-induction measured after overnight incubat...				Bioorg Med Chem Lett 22: 76-81 (2011) Article DOI: 10.1016/j.bmcl.2011.11.077 BindingDB Entry DOI: 10.7270/Q2XD12SN
					More data for this Ligand-Target Pair
Hypoxia-inducible factor 1-alpha (Homo sapiens (Human))	BDBM50393295 (CHEMBL2135309) Show SMILES C(Nc1nc(nnc1-c1ccccc1)-c1ccccn1)c1cccc(c1)-c1ccccc1 Show InChI InChI=1S/C27H21N5/c1-3-11-21(12-4-1)23-15-9-10-20(18-23)19-29-27-25(22-13-5-2-6-14-22)31-32-26(30-27)24-16-7-8-17-28-24/h1-18H,19H2,(H,29,30,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.57E+3	n/a	n/a	n/a	n/a
The Broad Institute Probe Development Center Curated by ChEMBL					Assay Description Activation of human HIF1alpha expressed in human U2OS cells assessed as increase in VEGF expression by RT-PCR analysis				Bioorg Med Chem Lett 22: 76-81 (2011) Article DOI: 10.1016/j.bmcl.2011.11.077 BindingDB Entry DOI: 10.7270/Q2XD12SN
					More data for this Ligand-Target Pair
Hypoxia-inducible factor 1-alpha (Homo sapiens (Human))	BDBM50393295 (CHEMBL2135309) Show SMILES C(Nc1nc(nnc1-c1ccccc1)-c1ccccn1)c1cccc(c1)-c1ccccc1 Show InChI InChI=1S/C27H21N5/c1-3-11-21(12-4-1)23-15-9-10-20(18-23)19-29-27-25(22-13-5-2-6-14-22)31-32-26(30-27)24-16-7-8-17-28-24/h1-18H,19H2,(H,29,30,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	500	n/a	n/a	n/a	n/a
The Broad Institute Probe Development Center Curated by ChEMBL					Assay Description Activation of GFP-tagged HIF1alpha expressed in human U2OS cells assessed as HIF1alpha nuclear translocation by high content imaging assay				Bioorg Med Chem Lett 22: 76-81 (2011) Article DOI: 10.1016/j.bmcl.2011.11.077 BindingDB Entry DOI: 10.7270/Q2XD12SN
					More data for this Ligand-Target Pair