BDBM50393513 CHEMBL2158059

SMILES: COc1ccc2c(CC[C@@]22CNC(=O)C2)c1OC1CCCC1

InChI Key: InChIKey=PWCZBGKUUMJJEK-GOSISDBHSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50393513   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP-specific 3',5'-cyclic phosphodiesterase 4A (Homo sapiens (Human))	BDBM50393513 (CHEMBL2158059) Show SMILES COc1ccc2c(CC[C@@]22CNC(=O)C2)c1OC1CCCC1 |r| Show InChI InChI=1S/C18H23NO3/c1-21-15-7-6-14-13(17(15)22-12-4-2-3-5-12)8-9-18(14)10-16(20)19-11-18/h6-7,12H,2-5,8-11H2,1H3,(H,19,20)/t18-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Glasgow Curated by ChEMBL					Assay Description Inhibition of full-length PDE4A4 using cAMP as substrate by two-step radiochemical assay				J Med Chem 54: 3331-47 (2011) Article DOI: 10.1021/jm200070e BindingDB Entry DOI: 10.7270/Q2CF9R75
					More data for this Ligand-Target Pair