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BDBM50393514 CHEMBL2158060

SMILES: COc1ccc2c(CC[C@]22CNC(=O)C2)c1OC1CCCC1

InChI Key: InChIKey=PWCZBGKUUMJJEK-SFHVURJKSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50393514   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (Human))
BDBM50393514
PNG
(CHEMBL2158060)
Show SMILES COc1ccc2c(CC[C@]22CNC(=O)C2)c1OC1CCCC1 |r|
Show InChI InChI=1S/C18H23NO3/c1-21-15-7-6-14-13(17(15)22-12-4-2-3-5-12)8-9-18(14)10-16(20)19-11-18/h6-7,12H,2-5,8-11H2,1H3,(H,19,20)/t18-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2.40E+4n/an/an/an/an/an/a



University of Glasgow

Curated by ChEMBL


Assay Description
Inhibition of full-length PDE4A4 using cAMP as substrate by two-step radiochemical assay


J Med Chem 54: 3331-47 (2011)


Article DOI: 10.1021/jm200070e
BindingDB Entry DOI: 10.7270/Q2CF9R75
More data for this
Ligand-Target Pair