BDBM50393791 CHEMBL2159345

SMILES: COc1ccc2cc(ccc2c1)-c1cc(nn1[C@@H](C)c1ccc(cc1)C(=O)NCCC(O)=O)C(F)(F)F

InChI Key: InChIKey=UTUASVOOVXPILR-INIZCTEOSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50393791   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glucagon receptor (Homo sapiens (Human))	BDBM50393791 (CHEMBL2159345) Show SMILES COc1ccc2cc(ccc2c1)-c1cc(nn1[C@@H](C)c1ccc(cc1)C(=O)NCCC(O)=O)C(F)(F)F |r| Show InChI InChI=1S/C27H24F3N3O4/c1-16(17-3-5-18(6-4-17)26(36)31-12-11-25(34)35)33-23(15-24(32-33)27(28,29)30)21-8-7-20-14-22(37-2)10-9-19(20)13-21/h3-10,13-16H,11-12H2,1-2H3,(H,31,36)(H,34,35)/t16-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	63	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Antagonist activity at human GCGR expressed in CHO cells assessed as inhibition of glucagon-induced cAMP accumulation preincubated for 30 mins prior ...				J Med Chem 55: 6137-48 (2012) Article DOI: 10.1021/jm300579z BindingDB Entry DOI: 10.7270/Q2X63P2C
					More data for this Ligand-Target Pair
Glucagon receptor (Homo sapiens (Human))	BDBM50393791 (CHEMBL2159345) Show SMILES COc1ccc2cc(ccc2c1)-c1cc(nn1[C@@H](C)c1ccc(cc1)C(=O)NCCC(O)=O)C(F)(F)F |r| Show InChI InChI=1S/C27H24F3N3O4/c1-16(17-3-5-18(6-4-17)26(36)31-12-11-25(34)35)33-23(15-24(32-33)27(28,29)30)21-8-7-20-14-22(37-2)10-9-19(20)13-21/h3-10,13-16H,11-12H2,1-2H3,(H,31,36)(H,34,35)/t16-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Displacement of [125I]glucagon from human GCGR expressed in CHO cells after 3 hrs by scintillation proximity assay				J Med Chem 55: 6137-48 (2012) Article DOI: 10.1021/jm300579z BindingDB Entry DOI: 10.7270/Q2X63P2C
					More data for this Ligand-Target Pair