null

SMILES: CCN(CC)c1ccc(OC)c2nc(c(C)cc12)-c1c(Cl)cc(COC)cc1OC

InChI Key: InChIKey=HDXQYYYZPINBML-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50394516   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50394516 (CHEMBL2160157) Show SMILES CCN(CC)c1ccc(OC)c2nc(c(C)cc12)-c1c(Cl)cc(COC)cc1OC |(3.38,8.07,;2.04,7.32,;2.01,5.78,;3.33,4.99,;4.69,5.72,;.67,5.04,;-.65,5.83,;-2,5.08,;-2.02,3.54,;-3.37,2.79,;-4.69,3.58,;-.7,2.75,;-.73,1.21,;.6,.42,;1.94,1.17,;3.26,.37,;1.96,2.7,;.64,3.5,;.57,-1.12,;1.89,-1.91,;3.24,-1.17,;1.87,-3.45,;.52,-4.2,;.5,-5.74,;1.82,-6.53,;1.8,-8.07,;-.8,-3.41,;-.77,-1.87,;-2.1,-1.08,;-3.44,-1.83,)| Show InChI InChI=1S/C24H29ClN2O3/c1-7-27(8-2)19-9-10-20(29-5)24-17(19)11-15(3)23(26-24)22-18(25)12-16(14-28-4)13-21(22)30-6/h9-13H,7-8,14H2,1-6H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	67	n/a	n/a	n/a	n/a	n/a	n/a
Eisai Co., Ltd Curated by ChEMBL					Assay Description Displacement of [125I]-CRF from human CRF1 receptor expressed in HEK293 cells after 2 hrs by scintillation counting				Bioorg Med Chem 20: 6559-78 (2012) Article DOI: 10.1016/j.bmc.2012.09.028 BindingDB Entry DOI: 10.7270/Q2B56KVZ
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50394516 (CHEMBL2160157) Show SMILES CCN(CC)c1ccc(OC)c2nc(c(C)cc12)-c1c(Cl)cc(COC)cc1OC |(3.38,8.07,;2.04,7.32,;2.01,5.78,;3.33,4.99,;4.69,5.72,;.67,5.04,;-.65,5.83,;-2,5.08,;-2.02,3.54,;-3.37,2.79,;-4.69,3.58,;-.7,2.75,;-.73,1.21,;.6,.42,;1.94,1.17,;3.26,.37,;1.96,2.7,;.64,3.5,;.57,-1.12,;1.89,-1.91,;3.24,-1.17,;1.87,-3.45,;.52,-4.2,;.5,-5.74,;1.82,-6.53,;1.8,-8.07,;-.8,-3.41,;-.77,-1.87,;-2.1,-1.08,;-3.44,-1.83,)| Show InChI InChI=1S/C24H29ClN2O3/c1-7-27(8-2)19-9-10-20(29-5)24-17(19)11-15(3)23(26-24)22-18(25)12-16(14-28-4)13-21(22)30-6/h9-13H,7-8,14H2,1-6H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
Eisai Co., Ltd Curated by ChEMBL					Assay Description Antagonist activity at human CRF1 receptor expressed in HEK293 cells assessed as inhibition of CRF-induced intracellular cAMP production preincubated...				Bioorg Med Chem 20: 6559-78 (2012) Article DOI: 10.1016/j.bmc.2012.09.028 BindingDB Entry DOI: 10.7270/Q2B56KVZ
					More data for this Ligand-Target Pair