Found 5 hits for monomerid = 50394840 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50394840
(CHEMBL2165005)Show SMILES COc1ccc(Nc2ncc(CN3CCS(=O)(=O)CC3)cc2-c2nc(C)nc(N)n2)cn1 Show InChI InChI=1S/C20H24N8O3S/c1-13-24-19(27-20(21)25-13)16-9-14(12-28-5-7-32(29,30)8-6-28)10-23-18(16)26-15-3-4-17(31-2)22-11-15/h3-4,9-11H,5-8,12H2,1-2H3,(H,23,26)(H2,21,24,25,27) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 13 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of human N-terminal poly-His tagged-PI3Kbeta expressed in Sf9 baculovirus system co-expressing p85alpha after 20 mins by AlphaScreen assay |
J Med Chem 55: 5188-219 (2012)
Article DOI: 10.1021/jm300184s BindingDB Entry DOI: 10.7270/Q23F4QSJ |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50394840
(CHEMBL2165005)Show SMILES COc1ccc(Nc2ncc(CN3CCS(=O)(=O)CC3)cc2-c2nc(C)nc(N)n2)cn1 Show InChI InChI=1S/C20H24N8O3S/c1-13-24-19(27-20(21)25-13)16-9-14(12-28-5-7-32(29,30)8-6-28)10-23-18(16)26-15-3-4-17(31-2)22-11-15/h3-4,9-11H,5-8,12H2,1-2H3,(H,23,26)(H2,21,24,25,27) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 13 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of human N-terminal poly-His tagged-PI3Kdelta expressed in Sf9 baculovirus system co-expressing p85alpha after 20 mins by AlphaScreen assa... |
J Med Chem 55: 5188-219 (2012)
Article DOI: 10.1021/jm300184s BindingDB Entry DOI: 10.7270/Q23F4QSJ |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM50394840
(CHEMBL2165005)Show SMILES COc1ccc(Nc2ncc(CN3CCS(=O)(=O)CC3)cc2-c2nc(C)nc(N)n2)cn1 Show InChI InChI=1S/C20H24N8O3S/c1-13-24-19(27-20(21)25-13)16-9-14(12-28-5-7-32(29,30)8-6-28)10-23-18(16)26-15-3-4-17(31-2)22-11-15/h3-4,9-11H,5-8,12H2,1-2H3,(H,23,26)(H2,21,24,25,27) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of human N-terminal poly-His tagged-PI3Kgamma expressed in Sf9 baculovirus system co-expressing p85alpha after 20 mins by AlphaScreen assa... |
J Med Chem 55: 5188-219 (2012)
Article DOI: 10.1021/jm300184s BindingDB Entry DOI: 10.7270/Q23F4QSJ |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50394840
(CHEMBL2165005)Show SMILES COc1ccc(Nc2ncc(CN3CCS(=O)(=O)CC3)cc2-c2nc(C)nc(N)n2)cn1 Show InChI InChI=1S/C20H24N8O3S/c1-13-24-19(27-20(21)25-13)16-9-14(12-28-5-7-32(29,30)8-6-28)10-23-18(16)26-15-3-4-17(31-2)22-11-15/h3-4,9-11H,5-8,12H2,1-2H3,(H,23,26)(H2,21,24,25,27) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 73 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of human N-terminal poly-His tagged-PI3Kalpha expressed in Sf9 baculovirus system co-expressing p85alpha after 20 mins by AlphaScreen assa... |
J Med Chem 55: 5188-219 (2012)
Article DOI: 10.1021/jm300184s BindingDB Entry DOI: 10.7270/Q23F4QSJ |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM50394840
(CHEMBL2165005)Show SMILES COc1ccc(Nc2ncc(CN3CCS(=O)(=O)CC3)cc2-c2nc(C)nc(N)n2)cn1 Show InChI InChI=1S/C20H24N8O3S/c1-13-24-19(27-20(21)25-13)16-9-14(12-28-5-7-32(29,30)8-6-28)10-23-18(16)26-15-3-4-17(31-2)22-11-15/h3-4,9-11H,5-8,12H2,1-2H3,(H,23,26)(H2,21,24,25,27) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of recombinant GST-tagged mTOR-mediated 4EBP1 phosphorylation after 90 mins by FRET assay |
J Med Chem 55: 5188-219 (2012)
Article DOI: 10.1021/jm300184s BindingDB Entry DOI: 10.7270/Q23F4QSJ |
More data for this Ligand-Target Pair | |