Found 7 hits for monomerid = 50394845 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50394845
(CHEMBL2165018 | US8772480, 211)Show SMILES COc1ccc(Nc2ncc(CN3CCN(CC3)S(=O)(=O)N(C)C)cc2-c2nc(C)nc(N)n2)cn1 Show InChI InChI=1S/C22H30N10O3S/c1-15-26-21(29-22(23)27-15)18-11-16(12-25-20(18)28-17-5-6-19(35-4)24-13-17)14-31-7-9-32(10-8-31)36(33,34)30(2)3/h5-6,11-13H,7-10,14H2,1-4H3,(H,25,28)(H2,23,26,27,29) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of human N-terminal poly-His tagged-PI3Kdelta expressed in Sf9 baculovirus system co-expressing p85alpha after 20 mins by AlphaScreen assa... |
J Med Chem 55: 5188-219 (2012)
Article DOI: 10.1021/jm300184s BindingDB Entry DOI: 10.7270/Q23F4QSJ |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50394845
(CHEMBL2165018 | US8772480, 211)Show SMILES COc1ccc(Nc2ncc(CN3CCN(CC3)S(=O)(=O)N(C)C)cc2-c2nc(C)nc(N)n2)cn1 Show InChI InChI=1S/C22H30N10O3S/c1-15-26-21(29-22(23)27-15)18-11-16(12-25-20(18)28-17-5-6-19(35-4)24-13-17)14-31-7-9-32(10-8-31)36(33,34)30(2)3/h5-6,11-13H,7-10,14H2,1-4H3,(H,25,28)(H2,23,26,27,29) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of human N-terminal poly-His tagged-PI3Kbeta expressed in Sf9 baculovirus system co-expressing p85alpha after 20 mins by AlphaScreen assay |
J Med Chem 55: 5188-219 (2012)
Article DOI: 10.1021/jm300184s BindingDB Entry DOI: 10.7270/Q23F4QSJ |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM50394845
(CHEMBL2165018 | US8772480, 211)Show SMILES COc1ccc(Nc2ncc(CN3CCN(CC3)S(=O)(=O)N(C)C)cc2-c2nc(C)nc(N)n2)cn1 Show InChI InChI=1S/C22H30N10O3S/c1-15-26-21(29-22(23)27-15)18-11-16(12-25-20(18)28-17-5-6-19(35-4)24-13-17)14-31-7-9-32(10-8-31)36(33,34)30(2)3/h5-6,11-13H,7-10,14H2,1-4H3,(H,25,28)(H2,23,26,27,29) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of human N-terminal poly-His tagged-PI3Kgamma expressed in Sf9 baculovirus system co-expressing p85alpha after 20 mins by AlphaScreen assa... |
J Med Chem 55: 5188-219 (2012)
Article DOI: 10.1021/jm300184s BindingDB Entry DOI: 10.7270/Q23F4QSJ |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50394845
(CHEMBL2165018 | US8772480, 211)Show SMILES COc1ccc(Nc2ncc(CN3CCN(CC3)S(=O)(=O)N(C)C)cc2-c2nc(C)nc(N)n2)cn1 Show InChI InChI=1S/C22H30N10O3S/c1-15-26-21(29-22(23)27-15)18-11-16(12-25-20(18)28-17-5-6-19(35-4)24-13-17)14-31-7-9-32(10-8-31)36(33,34)30(2)3/h5-6,11-13H,7-10,14H2,1-4H3,(H,25,28)(H2,23,26,27,29) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| US Patent
| 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
US Patent
| Assay Description The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kalpha, PI3Kbeta, PI... |
US Patent US8772480 (2014)
BindingDB Entry DOI: 10.7270/Q2V123FJ |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50394845
(CHEMBL2165018 | US8772480, 211)Show SMILES COc1ccc(Nc2ncc(CN3CCN(CC3)S(=O)(=O)N(C)C)cc2-c2nc(C)nc(N)n2)cn1 Show InChI InChI=1S/C22H30N10O3S/c1-15-26-21(29-22(23)27-15)18-11-16(12-25-20(18)28-17-5-6-19(35-4)24-13-17)14-31-7-9-32(10-8-31)36(33,34)30(2)3/h5-6,11-13H,7-10,14H2,1-4H3,(H,25,28)(H2,23,26,27,29) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of human N-terminal poly-His tagged-PI3Kalpha expressed in Sf9 baculovirus system co-expressing p85alpha after 20 mins by AlphaScreen assa... |
J Med Chem 55: 5188-219 (2012)
Article DOI: 10.1021/jm300184s BindingDB Entry DOI: 10.7270/Q23F4QSJ |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM50394845
(CHEMBL2165018 | US8772480, 211)Show SMILES COc1ccc(Nc2ncc(CN3CCN(CC3)S(=O)(=O)N(C)C)cc2-c2nc(C)nc(N)n2)cn1 Show InChI InChI=1S/C22H30N10O3S/c1-15-26-21(29-22(23)27-15)18-11-16(12-25-20(18)28-17-5-6-19(35-4)24-13-17)14-31-7-9-32(10-8-31)36(33,34)30(2)3/h5-6,11-13H,7-10,14H2,1-4H3,(H,25,28)(H2,23,26,27,29) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of recombinant GST-tagged mTOR-mediated 4EBP1 phosphorylation after 90 mins by FRET assay |
J Med Chem 55: 5188-219 (2012)
Article DOI: 10.1021/jm300184s BindingDB Entry DOI: 10.7270/Q23F4QSJ |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM50394845
(CHEMBL2165018 | US8772480, 211)Show SMILES COc1ccc(Nc2ncc(CN3CCN(CC3)S(=O)(=O)N(C)C)cc2-c2nc(C)nc(N)n2)cn1 Show InChI InChI=1S/C22H30N10O3S/c1-15-26-21(29-22(23)27-15)18-11-16(12-25-20(18)28-17-5-6-19(35-4)24-13-17)14-31-7-9-32(10-8-31)36(33,34)30(2)3/h5-6,11-13H,7-10,14H2,1-4H3,(H,25,28)(H2,23,26,27,29) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
US Patent
| Assay Description The Invitrogen (Carlsbad, Calif.) mammalian target of rapamycin (mTOR) Lanthascreen assay can be used to quantitate mTOR kinase activity in an in vit... |
US Patent US8772480 (2014)
BindingDB Entry DOI: 10.7270/Q2V123FJ |
More data for this Ligand-Target Pair | |