Found 5 hits for monomerid = 50394847 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50394847
(CHEMBL2165016)Show SMILES COc1ccc(Nc2ncc(CN3CCN(CC3)C(=O)N(C)C)cc2-c2nc(C)nc(N)n2)cn1 Show InChI InChI=1S/C23H30N10O2/c1-15-27-21(30-22(24)28-15)18-11-16(14-32-7-9-33(10-8-32)23(34)31(2)3)12-26-20(18)29-17-5-6-19(35-4)25-13-17/h5-6,11-13H,7-10,14H2,1-4H3,(H,26,29)(H2,24,27,28,30) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of human N-terminal poly-His tagged-PI3Kdelta expressed in Sf9 baculovirus system co-expressing p85alpha after 20 mins by AlphaScreen assa... |
J Med Chem 55: 5188-219 (2012)
Article DOI: 10.1021/jm300184s BindingDB Entry DOI: 10.7270/Q23F4QSJ |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM50394847
(CHEMBL2165016)Show SMILES COc1ccc(Nc2ncc(CN3CCN(CC3)C(=O)N(C)C)cc2-c2nc(C)nc(N)n2)cn1 Show InChI InChI=1S/C23H30N10O2/c1-15-27-21(30-22(24)28-15)18-11-16(14-32-7-9-33(10-8-32)23(34)31(2)3)12-26-20(18)29-17-5-6-19(35-4)25-13-17/h5-6,11-13H,7-10,14H2,1-4H3,(H,26,29)(H2,24,27,28,30) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of human N-terminal poly-His tagged-PI3Kgamma expressed in Sf9 baculovirus system co-expressing p85alpha after 20 mins by AlphaScreen assa... |
J Med Chem 55: 5188-219 (2012)
Article DOI: 10.1021/jm300184s BindingDB Entry DOI: 10.7270/Q23F4QSJ |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50394847
(CHEMBL2165016)Show SMILES COc1ccc(Nc2ncc(CN3CCN(CC3)C(=O)N(C)C)cc2-c2nc(C)nc(N)n2)cn1 Show InChI InChI=1S/C23H30N10O2/c1-15-27-21(30-22(24)28-15)18-11-16(14-32-7-9-33(10-8-32)23(34)31(2)3)12-26-20(18)29-17-5-6-19(35-4)25-13-17/h5-6,11-13H,7-10,14H2,1-4H3,(H,26,29)(H2,24,27,28,30) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 16 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of human N-terminal poly-His tagged-PI3Kbeta expressed in Sf9 baculovirus system co-expressing p85alpha after 20 mins by AlphaScreen assay |
J Med Chem 55: 5188-219 (2012)
Article DOI: 10.1021/jm300184s BindingDB Entry DOI: 10.7270/Q23F4QSJ |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50394847
(CHEMBL2165016)Show SMILES COc1ccc(Nc2ncc(CN3CCN(CC3)C(=O)N(C)C)cc2-c2nc(C)nc(N)n2)cn1 Show InChI InChI=1S/C23H30N10O2/c1-15-27-21(30-22(24)28-15)18-11-16(14-32-7-9-33(10-8-32)23(34)31(2)3)12-26-20(18)29-17-5-6-19(35-4)25-13-17/h5-6,11-13H,7-10,14H2,1-4H3,(H,26,29)(H2,24,27,28,30) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 84 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of human N-terminal poly-His tagged-PI3Kalpha expressed in Sf9 baculovirus system co-expressing p85alpha after 20 mins by AlphaScreen assa... |
J Med Chem 55: 5188-219 (2012)
Article DOI: 10.1021/jm300184s BindingDB Entry DOI: 10.7270/Q23F4QSJ |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM50394847
(CHEMBL2165016)Show SMILES COc1ccc(Nc2ncc(CN3CCN(CC3)C(=O)N(C)C)cc2-c2nc(C)nc(N)n2)cn1 Show InChI InChI=1S/C23H30N10O2/c1-15-27-21(30-22(24)28-15)18-11-16(14-32-7-9-33(10-8-32)23(34)31(2)3)12-26-20(18)29-17-5-6-19(35-4)25-13-17/h5-6,11-13H,7-10,14H2,1-4H3,(H,26,29)(H2,24,27,28,30) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of recombinant GST-tagged mTOR-mediated 4EBP1 phosphorylation after 90 mins by FRET assay |
J Med Chem 55: 5188-219 (2012)
Article DOI: 10.1021/jm300184s BindingDB Entry DOI: 10.7270/Q23F4QSJ |
More data for this Ligand-Target Pair | |