BDBM50395555 CHEMBL2165127

SMILES: Clc1cccc(N2CCN(CCCOc3ccc4CCC(=O)Nc4c3)CC2)c1Cl

InChI Key: InChIKey=FZNVIOULNRQSFK-UHFFFAOYSA-N

Data: 1 KI  2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50395555   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50395555 (CHEMBL2165127) Show SMILES Clc1cccc(N2CCN(CCCOc3ccc4CCC(=O)Nc4c3)CC2)c1Cl Show InChI InChI=1S/C22H25Cl2N3O2/c23-18-3-1-4-20(22(18)24)27-12-10-26(11-13-27)9-2-14-29-17-7-5-16-6-8-21(28)25-19(16)15-17/h1,3-5,7,15H,2,6,8-14H2,(H,25,28)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	21	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina at Chapel Hill Curated by ChEMBL					Assay Description Displacement of [3H]N-methylspiperone from human D2L receptor expressed in CHO cells after 1.5 hrs by microbeta counting method				J Med Chem 55: 7141-53 (2012) Article DOI: 10.1021/jm300603y BindingDB Entry DOI: 10.7270/Q2JD4XXH
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50395555 (CHEMBL2165127) Show SMILES Clc1cccc(N2CCN(CCCOc3ccc4CCC(=O)Nc4c3)CC2)c1Cl Show InChI InChI=1S/C22H25Cl2N3O2/c23-18-3-1-4-20(22(18)24)27-12-10-26(11-13-27)9-2-14-29-17-7-5-16-6-8-21(28)25-19(16)15-17/h1,3-5,7,15H,2,6,8-14H2,(H,25,28)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	251	n/a	n/a	n/a	n/a
University of North Carolina at Chapel Hill Curated by ChEMBL					Assay Description Agonist activity at human D2L receptor expressed in HEK293T cells coexpressing Gi subunit assessed as inhibition of isoproterenol-stimulated cAMP pro...				J Med Chem 55: 7141-53 (2012) Article DOI: 10.1021/jm300603y BindingDB Entry DOI: 10.7270/Q2JD4XXH
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50395555 (CHEMBL2165127) Show SMILES Clc1cccc(N2CCN(CCCOc3ccc4CCC(=O)Nc4c3)CC2)c1Cl Show InChI InChI=1S/C22H25Cl2N3O2/c23-18-3-1-4-20(22(18)24)27-12-10-26(11-13-27)9-2-14-29-17-7-5-16-6-8-21(28)25-19(16)15-17/h1,3-5,7,15H,2,6,8-14H2,(H,25,28)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	79	n/a	n/a	n/a	n/a
University of North Carolina at Chapel Hill Curated by ChEMBL					Assay Description Agonist activity at D2L receptor in human HTLA cells assessed as beta arrestin recruitment at 6 uM after 18 hrs by luminescence assay				J Med Chem 55: 7141-53 (2012) Article DOI: 10.1021/jm300603y BindingDB Entry DOI: 10.7270/Q2JD4XXH
					More data for this Ligand-Target Pair