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SMILES: Oc1ccc(Cn2nnc3ncc(nc23)-c2ccc(F)cc2)cc1

InChI Key: InChIKey=WQEBVEIWYSZODC-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50396950   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50396950 (CHEMBL2170810) Show SMILES Oc1ccc(Cn2nnc3ncc(nc23)-c2ccc(F)cc2)cc1 Show InChI InChI=1S/C17H12FN5O/c18-13-5-3-12(4-6-13)15-9-19-16-17(20-15)23(22-21-16)10-11-1-7-14(24)8-2-11/h1-9,24H,10H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	19.8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Competitive inhibition of N-terminal His6-tagged recombinant human c-MET (974 to 1390 amino acids) by spectrophotometry				J Med Chem 55: 8091-109 (2012) Article DOI: 10.1021/jm300967g BindingDB Entry DOI: 10.7270/Q2Z60Q59
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50396950 (CHEMBL2170810) Show SMILES Oc1ccc(Cn2nnc3ncc(nc23)-c2ccc(F)cc2)cc1 Show InChI InChI=1S/C17H12FN5O/c18-13-5-3-12(4-6-13)15-9-19-16-17(20-15)23(22-21-16)10-11-1-7-14(24)8-2-11/h1-9,24H,10H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	141	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at c-MET receptor in human A549 cells assessed as inhibition of autophosphorylation after 1 hr by ELISA				J Med Chem 55: 8091-109 (2012) Article DOI: 10.1021/jm300967g BindingDB Entry DOI: 10.7270/Q2Z60Q59
					More data for this Ligand-Target Pair