BDBM50397294 CHEMBL489271::VUF-10509
SMILES: CN1CCN(CC1)c1nc(NCc2ccc(N)cc2)c2cc(Cl)ccc2n1
InChI Key: InChIKey=YTLUXTFQLXDBJU-UHFFFAOYSA-N
Data: 3 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
5-hydroxytryptamine receptor 3A (Homo sapiens (Human)) | BDBM50397294 (CHEMBL489271 | VUF-10509) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 2.69 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
VU University Amsterdam Curated by ChEMBL | Assay Description Displacement of [3H]granisetron from 5HT3A receptor expressed in HEK293 cells after 24 hrs by scintillation counting in presence of quipazine | J Med Chem 55: 8603-14 (2012) Article DOI: 10.1021/jm300801u BindingDB Entry DOI: 10.7270/Q2RF5W5T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine H4 receptor (Homo sapiens (Human)) | BDBM50397294 (CHEMBL489271 | VUF-10509) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 562 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vrije Universiteit Amsterdam Curated by ChEMBL | Assay Description Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells | J Med Chem 51: 7855-65 (2008) Article DOI: 10.1021/jm800876b BindingDB Entry DOI: 10.7270/Q29Z964R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine H4 receptor (Homo sapiens (Human)) | BDBM50397294 (CHEMBL489271 | VUF-10509) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 562 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Griffin Discoveries BV Curated by ChEMBL | Assay Description Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells | J Med Chem 53: 2390-400 (2010) Article DOI: 10.1021/jm901379s BindingDB Entry DOI: 10.7270/Q2G44RJ4 | |||||||||||
More data for this Ligand-Target Pair |