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BDBM50397773 CHEMBL2177190

SMILES: CCC(CC)N1[C@@H]([C@H](C[C@](C)(CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1

InChI Key: InChIKey=YZXCLRHTZJADSX-GZGNHOFSSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50397773   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
CREB-binding protein/p53


(Homo sapiens (Human))		BDBM50397773
PNG
(CHEMBL2177190)
Show SMILES CCC(CC)N1[C@@H]([C@H](C[C@](C)(CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1 |r|
Show InChI InChI=1S/C25H29Cl2NO3/c1-4-20(5-2)28-23(16-9-11-18(26)12-10-16)21(17-7-6-8-19(27)13-17)14-25(3,24(28)31)15-22(29)30/h6-13,20-21,23H,4-5,14-15H2,1-3H3,(H,29,30)/t21-,23-,25-/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

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CHEMBL
PC cid
PC sid
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Similars
Article
PubMed
n/an/a 5.50E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Activity at p53 in human SJSA1 cells assessed as induction of p21 mRNA expression after 7 hrs by qRT-PCR analysis in presence of 10% human serum

J Med Chem 55: 4936-54 (2012)


Article DOI: 10.1021/jm300354j
BindingDB Entry DOI: 10.7270/Q2S75HGJ
More data for this
Ligand-Target Pair