BDBM50397961 CHEMBL2179988
SMILES: NC(=O)c1cccc(NC(=O)\C=C\C(O)=O)c1
InChI Key: InChIKey=GNFSYBNDPOBXLJ-SNAWJCMRSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Poly [ADP-ribose] polymerase 15 (Homo sapiens (Human)) | BDBM50397961 (CHEMBL2179988) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 1.78E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Karolinska Institutet Curated by ChEMBL | Assay Description Inhibition of hexahistidine-tagged human recombinant ARTD7 catalytic domain (459 to 656 amino acids) expressed in Escherichia coli BL21(DE3) assessed... | Eur J Med Chem 95: 546-51 (2015) Article DOI: 10.1016/j.ejmech.2015.03.067 BindingDB Entry DOI: 10.7270/Q23J3FPJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human)) | BDBM50397961 (CHEMBL2179988) | PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 3.63E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Karolinska Institutet Curated by ChEMBL | Assay Description Inhibition of hexahistidine-tagged full length human recombinant ARTD1 expressed in Escherichia coli BL21(DE3) assessed as Inhibition of ADP-ribosylt... | Eur J Med Chem 95: 546-51 (2015) Article DOI: 10.1016/j.ejmech.2015.03.067 BindingDB Entry DOI: 10.7270/Q23J3FPJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Poly [ADP-ribose] polymerase 10 (Homo sapiens (Human)) | BDBM50397961 (CHEMBL2179988) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 1.38E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Karolinska Institutet Curated by ChEMBL | Assay Description Inhibition of hexahistidine-tagged full length human recombinant ARTD10 expressed in Escherichia coli BL21(DE3) assessed as Inhibition of ADP-ribosyl... | Eur J Med Chem 95: 546-51 (2015) Article DOI: 10.1016/j.ejmech.2015.03.067 BindingDB Entry DOI: 10.7270/Q23J3FPJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Poly [ADP-ribose] polymerase 14 (Homo sapiens (Human)) | BDBM50397961 (CHEMBL2179988) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | n/a | 1.12E+4 | n/a | n/a | n/a | n/a | n/a |
Ume£ University Curated by ChEMBL | Assay Description Binding affinity at human recombinant ARTD8 expressed in Escherichia coli BL21 (DE3) R3 pRARE cells by isothermal titration calorimetry | J Med Chem 55: 7706-18 (2012) Article DOI: 10.1021/jm300746d BindingDB Entry DOI: 10.7270/Q2GT5P9F | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Poly [ADP-ribose] polymerase 10 (Homo sapiens (Human)) | BDBM50397961 (CHEMBL2179988) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Karolinska Institutet Curated by ChEMBL | Assay Description Inhibition of hexahistidine-tagged full length human recombinant ARTD10 expressed in Escherichia coli BL21(DE3) assessed as Inhibition of ADP-ribosyl... | Eur J Med Chem 95: 546-51 (2015) Article DOI: 10.1016/j.ejmech.2015.03.067 BindingDB Entry DOI: 10.7270/Q23J3FPJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Poly [ADP-ribose] polymerase 15 (Homo sapiens (Human)) | BDBM50397961 (CHEMBL2179988) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 1.78E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Karolinska Institutet Curated by ChEMBL | Assay Description Inhibition of hexahistidine-tagged human recombinant ARTD7 catalytic domain (459 to 656 amino acids) expressed in Escherichia coli BL21(DE3) assessed... | Eur J Med Chem 95: 546-51 (2015) Article DOI: 10.1016/j.ejmech.2015.03.067 BindingDB Entry DOI: 10.7270/Q23J3FPJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human)) | BDBM50397961 (CHEMBL2179988) | PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 3.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Karolinska Institutet Curated by ChEMBL | Assay Description Inhibition of hexahistidine-tagged full length human recombinant ARTD1 expressed in Escherichia coli BL21(DE3) assessed as Inhibition of ADP-ribosylt... | Eur J Med Chem 95: 546-51 (2015) Article DOI: 10.1016/j.ejmech.2015.03.067 BindingDB Entry DOI: 10.7270/Q23J3FPJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Poly [ADP-ribose] polymerase 14 (Homo sapiens (Human)) | BDBM50397961 (CHEMBL2179988) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Karolinska Institutet Curated by ChEMBL | Assay Description Inhibition of hexahistidine-tagged human recombinant ARTD8 catalytic domain (1611 to 1801 amino acids) expressed in Escherichia coli BL21(DE3) assess... | Eur J Med Chem 95: 546-51 (2015) Article DOI: 10.1016/j.ejmech.2015.03.067 BindingDB Entry DOI: 10.7270/Q23J3FPJ | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |