BindingDB PrimarySearch

BDBM50399088 CHEMBL2179319

SMILES: FC(F)(F)c1c(ccn2c(CC3CC3)nnc12)N1CCC(CC1)c1ccccc1

InChI Key: InChIKey=BQAVZGJJQFJSMW-UHFFFAOYSA-N

Data: 1 KI 6 IC50 4 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50399088
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50399088 (CHEMBL2179319) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	15	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research& Development Curated by ChEMBL					Assay Description Displacement of [3H]8-Trifluoromethyl-3-cyclopropylmethyl-7-[(4-phenyl-1-piperidinyl)methyl]-1,2,4-triazolo[4,3-a]pyridine from mGlu2 receptor (unkno...				J Med Chem 59: 8495-507 (2016) Article DOI: 10.1021/acs.jmedchem.6b00913 BindingDB Entry DOI: 10.7270/Q27M09WC
Janssen Research& Development Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 2C19 (Homo sapiens (Human))	BDBM50399088 (CHEMBL2179319) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Janssen-Cilag S.A. Curated by ChEMBL					Assay Description Inhibition of CYP2C19				J Med Chem 55: 8770-89 (2012) Article DOI: 10.1021/jm3010724 BindingDB Entry DOI: 10.7270/Q26111FF
Janssen-Cilag S.A. Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 2C9 (Homo sapiens (Human))	BDBM50399088 (CHEMBL2179319) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
Janssen-Cilag S.A. Curated by ChEMBL					Assay Description Inhibition of CYP2C9				J Med Chem 55: 8770-89 (2012) Article DOI: 10.1021/jm3010724 BindingDB Entry DOI: 10.7270/Q26111FF
Janssen-Cilag S.A. Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM50399088 (CHEMBL2179319) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Janssen-Cilag S.A. Curated by ChEMBL					Assay Description Inhibition of CYP3A4				J Med Chem 55: 8770-89 (2012) Article DOI: 10.1021/jm3010724 BindingDB Entry DOI: 10.7270/Q26111FF
Janssen-Cilag S.A. Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 2D6 (Homo sapiens (Human))	BDBM50399088 (CHEMBL2179319) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Janssen-Cilag S.A. Curated by ChEMBL					Assay Description Inhibition of CYP2D6				J Med Chem 55: 8770-89 (2012) Article DOI: 10.1021/jm3010724 BindingDB Entry DOI: 10.7270/Q26111FF
Janssen-Cilag S.A. Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50399088 (CHEMBL2179319) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	4.80	n/a	n/a	n/a	n/a
Janssen Research& Development Curated by ChEMBL					Assay Description Positive allosteric modulation of wild-type human mGlu2 receptor expressed in CHO-K1 cells assessed as potentiation of glutamate-induced effect incub...				J Med Chem 59: 8495-507 (2016) Article DOI: 10.1021/acs.jmedchem.6b00913 BindingDB Entry DOI: 10.7270/Q27M09WC
Janssen Research& Development Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50399088 (CHEMBL2179319) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Janssen-Cilag S.A. Curated by ChEMBL					Assay Description Binding affinity to human mGlu2R expressed in CHO cells by radioligand binding assay				J Med Chem 55: 8770-89 (2012) Article DOI: 10.1021/jm3010724 BindingDB Entry DOI: 10.7270/Q26111FF
Janssen-Cilag S.A. Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50399088 (CHEMBL2179319) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	270	n/a	n/a	n/a	n/a
Janssen-Cilag S.A. Curated by ChEMBL					Assay Description Agonist activity at human mGlu2R expressed in CHO cells				J Med Chem 55: 8770-89 (2012) Article DOI: 10.1021/jm3010724 BindingDB Entry DOI: 10.7270/Q26111FF
Janssen-Cilag S.A. Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50399088 (CHEMBL2179319) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	17	n/a	n/a	n/a	n/a
Janssen Research& Development Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGlu2 receptor expressed in CHO cell membranes assessed as potentiation of glutamate-induced effect incubated...				J Med Chem 59: 8495-507 (2016) Article DOI: 10.1021/acs.jmedchem.6b00913 BindingDB Entry DOI: 10.7270/Q27M09WC
Janssen Research& Development Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50399088 (CHEMBL2179319) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	17	n/a	n/a	n/a	n/a
Janssen-Cilag S.A. Curated by ChEMBL					Assay Description Positive allosteric modulator activity at human mGlu2R expressed in CHO cells incubated for 30 mins by [35S]GTPgammaS binding assay				J Med Chem 55: 8770-89 (2012) Article DOI: 10.1021/jm3010724 BindingDB Entry DOI: 10.7270/Q26111FF
Janssen-Cilag S.A. Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 1A (Homo sapiens (Human))	BDBM50399088 (CHEMBL2179319) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Janssen-Cilag S.A. Curated by ChEMBL					Assay Description Inhibition of CYP1A2				J Med Chem 55: 8770-89 (2012) Article DOI: 10.1021/jm3010724 BindingDB Entry DOI: 10.7270/Q26111FF
Janssen-Cilag S.A. Curated by ChEMBL					More data for this Ligand-Target Pair