BDBM50399346 CHEMBL2180883

SMILES: OC(=O)c1ccc(cc1)-n1ncc(C(=O)NC2C3CC4CC(C3)CC2C4)c1SC1CCCC1

InChI Key: InChIKey=GCYAFRUPMDHRRG-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50399346   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50399346 (CHEMBL2180883) Show SMILES OC(=O)c1ccc(cc1)-n1ncc(C(=O)NC2C3CC4CC(C3)CC2C4)c1SC1CCCC1 |TLB:15:16:18.25.19:23.21.22,25:24:22:18.19.20,THB:15:16:22:18.19.20,25:19:16.24.23:22,20:19:16:23.21.22,20:21:16:18.25.19,(27.7,-42.8,;29.23,-42.96,;29.85,-44.37,;30.13,-41.71,;29.51,-40.3,;30.41,-39.06,;31.95,-39.23,;32.57,-40.63,;31.67,-41.87,;32.85,-37.99,;32.38,-36.52,;33.62,-35.61,;34.87,-36.52,;36.34,-36.05,;36.66,-34.54,;37.48,-37.08,;38.95,-36.61,;40.14,-35.33,;41.47,-35.82,;42.87,-35.47,;42.88,-33.95,;41.48,-33.37,;40.13,-33.85,;40.44,-34.6,;40.45,-36.19,;41.85,-36.75,;34.39,-37.99,;35.3,-39.23,;34.67,-40.64,;33.17,-40.96,;33,-42.49,;34.41,-43.12,;35.44,-41.97,)| Show InChI InChI=1S/C26H31N3O3S/c30-24(28-23-18-10-15-9-16(12-18)13-19(23)11-15)22-14-27-29(25(22)33-21-3-1-2-4-21)20-7-5-17(6-8-20)26(31)32/h5-8,14-16,18-19,21,23H,1-4,9-13H2,(H,28,30)(H,31,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of N-terminal 6-His tagged full length human 11betaHSD1 incubated for 25 mins by HTRF assay				J Med Chem 55: 10136-47 (2012) Article DOI: 10.1021/jm301252n BindingDB Entry DOI: 10.7270/Q2WM1FJT
					More data for this Ligand-Target Pair