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SMILES: CS(=O)(=O)c1ccc(F)cc1C(=O)N1CCC(CC1)N(C1CC1)S(=O)(=O)c1cc(ccc1F)C(F)(F)F

InChI Key: InChIKey=LOVTTXXKAQYXQB-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50399543   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Voltage-dependent N-type calcium channel subunit alpha-1B


(Homo sapiens (Human))		BDBM50399543
PNG
(CHEMBL2180887)
Show SMILES CS(=O)(=O)c1ccc(F)cc1C(=O)N1CCC(CC1)N(C1CC1)S(=O)(=O)c1cc(ccc1F)C(F)(F)F
Show InChI InChI=1S/C23H23F5N2O5S2/c1-36(32,33)20-7-3-15(24)13-18(20)22(31)29-10-8-17(9-11-29)30(16-4-5-16)37(34,35)21-12-14(23(26,27)28)2-6-19(21)25/h2-3,6-7,12-13,16-17H,4-5,8-11H2,1H3
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Similars
Article
PubMed
n/an/a 2.50E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Cav2.2 expressed HEK293 cells assessed as inhibition of calcium flux by FLIPR assay in presence of 30 mM of potassium

J Med Chem 55: 9847-55 (2012)


Article DOI: 10.1021/jm301056k
BindingDB Entry DOI: 10.7270/Q26W9C7J
More data for this
Ligand-Target Pair