Found 3 hits for monomerid = 50399810 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Neuronal acetylcholine receptor protein alpha-7 subunit
(Homo sapiens (Human)) | BDBM50399810
(CHEMBL2179844)Show SMILES COc1ccc(cc1)C(=O)N[C@@H]1C2CCN(CC2)[C@H]1Cc1cccnc1 |r,wU:11.11,wD:18.21,(23.91,-38.77,;22.58,-38,;21.25,-38.76,;21.24,-40.31,;19.9,-41.07,;18.58,-40.29,;18.57,-38.76,;19.9,-37.99,;17.24,-41.06,;17.24,-42.6,;15.91,-40.28,;14.58,-41.05,;13.25,-40.27,;11.92,-41.05,;11.92,-42.59,;13.25,-43.35,;12.46,-42.01,;13.84,-41.52,;14.58,-42.59,;15.91,-43.36,;15.91,-44.9,;14.57,-45.67,;14.57,-47.2,;15.9,-47.98,;17.24,-47.2,;17.24,-45.67,)| Show InChI InChI=1S/C21H25N3O2/c1-26-18-6-4-17(5-7-18)21(25)23-20-16-8-11-24(12-9-16)19(20)13-15-3-2-10-22-14-15/h2-7,10,14,16,19-20H,8-9,11-13H2,1H3,(H,23,25)/t19-,20+/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 6.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Targacept, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]epibatidine form human alpha7 nAchR expressed in HEK293 cells |
J Med Chem 55: 9793-809 (2012)
Article DOI: 10.1021/jm301048a
BindingDB Entry DOI: 10.7270/Q2J67J2T |
More data for this
Ligand-Target Pair | |
Neuronal acetylcholine receptor Alpha-4/Beta-2
(Homo sapiens (Human)) | BDBM50399810
(CHEMBL2179844)Show SMILES COc1ccc(cc1)C(=O)N[C@@H]1C2CCN(CC2)[C@H]1Cc1cccnc1 |r,wU:11.11,wD:18.21,(23.91,-38.77,;22.58,-38,;21.25,-38.76,;21.24,-40.31,;19.9,-41.07,;18.58,-40.29,;18.57,-38.76,;19.9,-37.99,;17.24,-41.06,;17.24,-42.6,;15.91,-40.28,;14.58,-41.05,;13.25,-40.27,;11.92,-41.05,;11.92,-42.59,;13.25,-43.35,;12.46,-42.01,;13.84,-41.52,;14.58,-42.59,;15.91,-43.36,;15.91,-44.9,;14.57,-45.67,;14.57,-47.2,;15.9,-47.98,;17.24,-47.2,;17.24,-45.67,)| Show InChI InChI=1S/C21H25N3O2/c1-26-18-6-4-17(5-7-18)21(25)23-20-16-8-11-24(12-9-16)19(20)13-15-3-2-10-22-14-15/h2-7,10,14,16,19-20H,8-9,11-13H2,1H3,(H,23,25)/t19-,20+/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 900 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Targacept, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]nicotine human alpha4beta2 nAChR in SH-EP1 cell membranes |
J Med Chem 55: 9793-809 (2012)
Article DOI: 10.1021/jm301048a
BindingDB Entry DOI: 10.7270/Q2J67J2T |
More data for this
Ligand-Target Pair | |
Neuronal acetylcholine receptor
(Rattus norvegicus (Rat)) | BDBM50399810
(CHEMBL2179844)Show SMILES COc1ccc(cc1)C(=O)N[C@@H]1C2CCN(CC2)[C@H]1Cc1cccnc1 |r,wU:11.11,wD:18.21,(23.91,-38.77,;22.58,-38,;21.25,-38.76,;21.24,-40.31,;19.9,-41.07,;18.58,-40.29,;18.57,-38.76,;19.9,-37.99,;17.24,-41.06,;17.24,-42.6,;15.91,-40.28,;14.58,-41.05,;13.25,-40.27,;11.92,-41.05,;11.92,-42.59,;13.25,-43.35,;12.46,-42.01,;13.84,-41.52,;14.58,-42.59,;15.91,-43.36,;15.91,-44.9,;14.57,-45.67,;14.57,-47.2,;15.9,-47.98,;17.24,-47.2,;17.24,-45.67,)| Show InChI InChI=1S/C21H25N3O2/c1-26-18-6-4-17(5-7-18)21(25)23-20-16-8-11-24(12-9-16)19(20)13-15-3-2-10-22-14-15/h2-7,10,14,16,19-20H,8-9,11-13H2,1H3,(H,23,25)/t19-,20+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 60 | n/a | n/a | n/a | n/a |
Targacept, Inc.
Curated by ChEMBL
| Assay Description
Agonist activity at rat alpha7 nAchR expressed in GH4C1 cells by whole cell patch clamp assay |
J Med Chem 55: 9793-809 (2012)
Article DOI: 10.1021/jm301048a
BindingDB Entry DOI: 10.7270/Q2J67J2T |
More data for this
Ligand-Target Pair | |
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