BDBM50400081 CHEMBL2178399

SMILES: O=C(Nc1cccc(c1)C(=O)OCCN1CCOCC1)\C=C\Oc1ccc(cc1)C12CC3CC(CC(C3)C1)C2

InChI Key: InChIKey=KNKKZWPDCMPLGC-XYOKQWHBSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50400081   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Hypoxia-inducible factor 1-alpha (Homo sapiens (Human))	BDBM50400081 (CHEMBL2178399) Show SMILES O=C(Nc1cccc(c1)C(=O)OCCN1CCOCC1)\C=C\Oc1ccc(cc1)C12CC3CC(CC(C3)C1)C2 |TLB:26:29:32:36.34.35,THB:34:33:30:36.35.37,34:35:32.33.38:30,37:35:32:38.29.30,37:29:32:36.34.35| Show InChI InChI=1S/C32H38N2O5/c35-30(33-28-3-1-2-26(19-28)31(36)39-15-11-34-9-13-37-14-10-34)8-12-38-29-6-4-27(5-7-29)32-20-23-16-24(21-32)18-25(17-23)22-32/h1-8,12,19,23-25H,9-11,13-18,20-22H2,(H,33,35)/b12-8+	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
Dongguk University-Seoul Curated by ChEMBL					Assay Description Inhibition of HIF1alpha in human HCT116 cells under hypoxic condition after 16 hrs by dual luciferase reporter gene assay				J Med Chem 55: 10564-71 (2012) Article DOI: 10.1021/jm301419d BindingDB Entry DOI: 10.7270/Q2QR4Z8D
					More data for this Ligand-Target Pair