Found 5 hits for monomerid = 50400136 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50400136
(CHEMBL2179452)Show SMILES O[C@@]12CC3CC(C1)[C@H](NC(=O)c1cnc(NC4CCOCC4)nc1C1CCC1)C(C3)C2 |r,wU:7.8,wD:1.0,TLB:0:1:7:29.3.4,8:7:6.30.1:29.3.4,8:7:4:6.1.2,THB:0:1:7.28.29:4,2:1:7:29.3.4,2:3:7:6.30.1,30:28:4:6.1.2,30:1:7.28.29:4,(73.77,-13.85,;72.24,-13.84,;71.19,-12.72,;69.78,-13.26,;69.13,-14.53,;70.16,-15.61,;71.46,-15.06,;70.17,-17.35,;68.84,-18.14,;67.5,-17.37,;67.5,-15.83,;66.17,-18.15,;64.83,-17.38,;63.5,-18.15,;63.5,-19.7,;62.16,-20.46,;60.83,-19.7,;60.84,-18.16,;59.52,-17.38,;58.17,-18.15,;58.17,-19.69,;59.51,-20.47,;64.83,-20.47,;66.17,-19.7,;67.51,-20.46,;67.9,-21.95,;69.39,-21.55,;68.99,-20.06,;70.97,-16.03,;69.8,-14.7,;72.38,-15.47,)| Show InChI InChI=1S/C24H34N4O3/c29-22(27-20-16-8-14-9-17(20)12-24(30,10-14)11-16)19-13-25-23(26-18-4-6-31-7-5-18)28-21(19)15-2-1-3-15/h13-18,20,30H,1-12H2,(H,27,29)(H,25,26,28)/t14?,16?,17?,20-,24- | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of human 11beta-HSD1 by HTRF assay |
J Med Chem 55: 10652-61 (2012)
Article DOI: 10.1021/jm3013163 BindingDB Entry DOI: 10.7270/Q2BG2Q4S |
More data for this Ligand-Target Pair | |
Estradiol 17-beta-dehydrogenase 1 (17beta-HSD1)
(Homo sapiens (Human)) | BDBM50400136
(CHEMBL2179452)Show SMILES O[C@@]12CC3CC(C1)[C@H](NC(=O)c1cnc(NC4CCOCC4)nc1C1CCC1)C(C3)C2 |r,wU:7.8,wD:1.0,TLB:0:1:7:29.3.4,8:7:6.30.1:29.3.4,8:7:4:6.1.2,THB:0:1:7.28.29:4,2:1:7:29.3.4,2:3:7:6.30.1,30:28:4:6.1.2,30:1:7.28.29:4,(73.77,-13.85,;72.24,-13.84,;71.19,-12.72,;69.78,-13.26,;69.13,-14.53,;70.16,-15.61,;71.46,-15.06,;70.17,-17.35,;68.84,-18.14,;67.5,-17.37,;67.5,-15.83,;66.17,-18.15,;64.83,-17.38,;63.5,-18.15,;63.5,-19.7,;62.16,-20.46,;60.83,-19.7,;60.84,-18.16,;59.52,-17.38,;58.17,-18.15,;58.17,-19.69,;59.51,-20.47,;64.83,-20.47,;66.17,-19.7,;67.51,-20.46,;67.9,-21.95,;69.39,-21.55,;68.99,-20.06,;70.97,-16.03,;69.8,-14.7,;72.38,-15.47,)| Show InChI InChI=1S/C24H34N4O3/c29-22(27-20-16-8-14-9-17(20)12-24(30,10-14)11-16)19-13-25-23(26-18-4-6-31-7-5-18)28-21(19)15-2-1-3-15/h13-18,20,30H,1-12H2,(H,27,29)(H,25,26,28)/t14?,16?,17?,20-,24- | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >3.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of human 17beta-HSD1 by HPLC assay |
J Med Chem 55: 10652-61 (2012)
Article DOI: 10.1021/jm3013163 BindingDB Entry DOI: 10.7270/Q2BG2Q4S |
More data for this Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Mus musculus (mouse)) | BDBM50400136
(CHEMBL2179452)Show SMILES O[C@@]12CC3CC(C1)[C@H](NC(=O)c1cnc(NC4CCOCC4)nc1C1CCC1)C(C3)C2 |r,wU:7.8,wD:1.0,TLB:0:1:7:29.3.4,8:7:6.30.1:29.3.4,8:7:4:6.1.2,THB:0:1:7.28.29:4,2:1:7:29.3.4,2:3:7:6.30.1,30:28:4:6.1.2,30:1:7.28.29:4,(73.77,-13.85,;72.24,-13.84,;71.19,-12.72,;69.78,-13.26,;69.13,-14.53,;70.16,-15.61,;71.46,-15.06,;70.17,-17.35,;68.84,-18.14,;67.5,-17.37,;67.5,-15.83,;66.17,-18.15,;64.83,-17.38,;63.5,-18.15,;63.5,-19.7,;62.16,-20.46,;60.83,-19.7,;60.84,-18.16,;59.52,-17.38,;58.17,-18.15,;58.17,-19.69,;59.51,-20.47,;64.83,-20.47,;66.17,-19.7,;67.51,-20.46,;67.9,-21.95,;69.39,-21.55,;68.99,-20.06,;70.97,-16.03,;69.8,-14.7,;72.38,-15.47,)| Show InChI InChI=1S/C24H34N4O3/c29-22(27-20-16-8-14-9-17(20)12-24(30,10-14)11-16)19-13-25-23(26-18-4-6-31-7-5-18)28-21(19)15-2-1-3-15/h13-18,20,30H,1-12H2,(H,27,29)(H,25,26,28)/t14?,16?,17?,20-,24- | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of mouse 11beta-HSD1 by HTRF assay |
J Med Chem 55: 10652-61 (2012)
Article DOI: 10.1021/jm3013163 BindingDB Entry DOI: 10.7270/Q2BG2Q4S |
More data for this Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50400136
(CHEMBL2179452)Show SMILES O[C@@]12CC3CC(C1)[C@H](NC(=O)c1cnc(NC4CCOCC4)nc1C1CCC1)C(C3)C2 |r,wU:7.8,wD:1.0,TLB:0:1:7:29.3.4,8:7:6.30.1:29.3.4,8:7:4:6.1.2,THB:0:1:7.28.29:4,2:1:7:29.3.4,2:3:7:6.30.1,30:28:4:6.1.2,30:1:7.28.29:4,(73.77,-13.85,;72.24,-13.84,;71.19,-12.72,;69.78,-13.26,;69.13,-14.53,;70.16,-15.61,;71.46,-15.06,;70.17,-17.35,;68.84,-18.14,;67.5,-17.37,;67.5,-15.83,;66.17,-18.15,;64.83,-17.38,;63.5,-18.15,;63.5,-19.7,;62.16,-20.46,;60.83,-19.7,;60.84,-18.16,;59.52,-17.38,;58.17,-18.15,;58.17,-19.69,;59.51,-20.47,;64.83,-20.47,;66.17,-19.7,;67.51,-20.46,;67.9,-21.95,;69.39,-21.55,;68.99,-20.06,;70.97,-16.03,;69.8,-14.7,;72.38,-15.47,)| Show InChI InChI=1S/C24H34N4O3/c29-22(27-20-16-8-14-9-17(20)12-24(30,10-14)11-16)19-13-25-23(26-18-4-6-31-7-5-18)28-21(19)15-2-1-3-15/h13-18,20,30H,1-12H2,(H,27,29)(H,25,26,28)/t14?,16?,17?,20-,24- | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of human 11beta-HSD1 by HPLC assay |
J Med Chem 55: 10652-61 (2012)
Article DOI: 10.1021/jm3013163 BindingDB Entry DOI: 10.7270/Q2BG2Q4S |
More data for this Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 2
(Homo sapiens (Human)) | BDBM50400136
(CHEMBL2179452)Show SMILES O[C@@]12CC3CC(C1)[C@H](NC(=O)c1cnc(NC4CCOCC4)nc1C1CCC1)C(C3)C2 |r,wU:7.8,wD:1.0,TLB:0:1:7:29.3.4,8:7:6.30.1:29.3.4,8:7:4:6.1.2,THB:0:1:7.28.29:4,2:1:7:29.3.4,2:3:7:6.30.1,30:28:4:6.1.2,30:1:7.28.29:4,(73.77,-13.85,;72.24,-13.84,;71.19,-12.72,;69.78,-13.26,;69.13,-14.53,;70.16,-15.61,;71.46,-15.06,;70.17,-17.35,;68.84,-18.14,;67.5,-17.37,;67.5,-15.83,;66.17,-18.15,;64.83,-17.38,;63.5,-18.15,;63.5,-19.7,;62.16,-20.46,;60.83,-19.7,;60.84,-18.16,;59.52,-17.38,;58.17,-18.15,;58.17,-19.69,;59.51,-20.47,;64.83,-20.47,;66.17,-19.7,;67.51,-20.46,;67.9,-21.95,;69.39,-21.55,;68.99,-20.06,;70.97,-16.03,;69.8,-14.7,;72.38,-15.47,)| Show InChI InChI=1S/C24H34N4O3/c29-22(27-20-16-8-14-9-17(20)12-24(30,10-14)11-16)19-13-25-23(26-18-4-6-31-7-5-18)28-21(19)15-2-1-3-15/h13-18,20,30H,1-12H2,(H,27,29)(H,25,26,28)/t14?,16?,17?,20-,24- | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of human 11beta-HSD2 by HTRF assay |
J Med Chem 55: 10652-61 (2012)
Article DOI: 10.1021/jm3013163 BindingDB Entry DOI: 10.7270/Q2BG2Q4S |
More data for this Ligand-Target Pair | |