Found 2 hits for monomerid = 50400148 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
11-beta-hydroxysteroid dehydrogenase 1
(Mus musculus (mouse)) | BDBM50400148
(CHEMBL2179457)Show SMILES O[C@@]12CC3CC(C1)[C@H](NC(=O)c1cnc(N[C@@H]4CCOC4)nc1C1CCCC1)C(C3)C2 |r,wU:7.8,wD:1.0,16.16,TLB:0:1:7:29.3.4,8:7:6.30.1:29.3.4,8:7:4:6.1.2,THB:0:1:7.28.29:4,2:1:7:29.3.4,2:3:7:6.30.1,30:28:4:6.1.2,30:1:7.28.29:4,(15.88,-39.27,;14.35,-39.26,;13.3,-38.14,;11.89,-38.68,;11.24,-39.95,;12.27,-41.03,;13.57,-40.47,;12.28,-42.77,;10.94,-43.55,;9.61,-42.78,;9.6,-41.24,;8.28,-43.56,;6.94,-42.79,;5.61,-43.57,;5.61,-45.11,;4.28,-45.88,;2.94,-45.11,;1.53,-45.73,;.5,-44.58,;1.27,-43.25,;2.78,-43.57,;6.95,-45.88,;8.28,-45.11,;9.62,-45.88,;9.78,-47.4,;11.29,-47.72,;12.06,-46.39,;11.02,-45.24,;13.08,-41.45,;11.91,-40.12,;14.49,-40.88,)| Show InChI InChI=1S/C24H34N4O3/c29-22(27-20-16-7-14-8-17(20)11-24(30,9-14)10-16)19-12-25-23(26-18-5-6-31-13-18)28-21(19)15-3-1-2-4-15/h12,14-18,20,30H,1-11,13H2,(H,27,29)(H,25,26,28)/t14?,16?,17?,18-,20-,24-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of mouse 11beta-HSD1 by HTRF assay |
J Med Chem 55: 10652-61 (2012)
Article DOI: 10.1021/jm3013163
BindingDB Entry DOI: 10.7270/Q2BG2Q4S |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50400148
(CHEMBL2179457)Show SMILES O[C@@]12CC3CC(C1)[C@H](NC(=O)c1cnc(N[C@@H]4CCOC4)nc1C1CCCC1)C(C3)C2 |r,wU:7.8,wD:1.0,16.16,TLB:0:1:7:29.3.4,8:7:6.30.1:29.3.4,8:7:4:6.1.2,THB:0:1:7.28.29:4,2:1:7:29.3.4,2:3:7:6.30.1,30:28:4:6.1.2,30:1:7.28.29:4,(15.88,-39.27,;14.35,-39.26,;13.3,-38.14,;11.89,-38.68,;11.24,-39.95,;12.27,-41.03,;13.57,-40.47,;12.28,-42.77,;10.94,-43.55,;9.61,-42.78,;9.6,-41.24,;8.28,-43.56,;6.94,-42.79,;5.61,-43.57,;5.61,-45.11,;4.28,-45.88,;2.94,-45.11,;1.53,-45.73,;.5,-44.58,;1.27,-43.25,;2.78,-43.57,;6.95,-45.88,;8.28,-45.11,;9.62,-45.88,;9.78,-47.4,;11.29,-47.72,;12.06,-46.39,;11.02,-45.24,;13.08,-41.45,;11.91,-40.12,;14.49,-40.88,)| Show InChI InChI=1S/C24H34N4O3/c29-22(27-20-16-7-14-8-17(20)11-24(30,9-14)10-16)19-12-25-23(26-18-5-6-31-13-18)28-21(19)15-3-1-2-4-15/h12,14-18,20,30H,1-11,13H2,(H,27,29)(H,25,26,28)/t14?,16?,17?,18-,20-,24-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of human 11beta-HSD1 by HTRF assay |
J Med Chem 55: 10652-61 (2012)
Article DOI: 10.1021/jm3013163
BindingDB Entry DOI: 10.7270/Q2BG2Q4S |
More data for this
Ligand-Target Pair | |
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