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SMILES: CCNC(=O)Nc1ccc(cc1)-c1nc2CN(Cc2c(n1)N1CCOCC1)C(=O)NCC

InChI Key: InChIKey=DGSJRYABRBQXGS-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50400358   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM50400358
PNG
(CHEMBL2181528)
Show SMILES CCNC(=O)Nc1ccc(cc1)-c1nc2CN(Cc2c(n1)N1CCOCC1)C(=O)NCC
Show InChI InChI=1S/C22H29N7O3/c1-3-23-21(30)25-16-7-5-15(6-8-16)19-26-18-14-29(22(31)24-4-2)13-17(18)20(27-19)28-9-11-32-12-10-28/h5-8H,3-4,9-14H2,1-2H3,(H,24,31)(H2,23,25,30)
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MMDB

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Similars
Article
PubMed
 5.10n/an/an/an/an/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Inhibition of human recombinant mTOR by FRET assay

J Med Chem 55: 10958-71 (2012)


Article DOI: 10.1021/jm301389h
BindingDB Entry DOI: 10.7270/Q2125TSR
More data for this
Ligand-Target Pair